No Association Between<i>IL12B</i>Gene Polymorphisms and Graves’ Disease in the Chinese Population

Liu, Shu; Hou, Peng; Morahan, Grant; Shi, Bingyin

doi:10.3109/07435800.2012.663846

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…IL-10 and IL-4) may be responsible for mediating IL-12 generation [51]. In accordance with our results, no association was found between rs6887695 variant in Graves' disease [52], psoriasis [45,53] and Crohn's disease [54].…”

Section: Discussionsupporting

confidence: 89%

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

et al. 2013

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Brucellosis remains a major zoonosis worldwide. Brucella antigens induce the production of T-helper 1 (Th1) cytokines such as interleukin-12 (IL-12) in humans. We aimed to investigate the association of two single nucleotide polymorphisms (SNPs) in the gene encoding the IL-12p40 cytokine (IL-12B) with brucellosis and to examine the functionality of these SNPs through measuring serum levels of IL-12p40. We genotyped IL-12B gene rs3212227, A>C; rs6887695 G>C polymorphisms in a case-control study on a total of 281 subjects including 153 patients with active brucellosis and 128 healthy controls, using RFLP and serum IL-12p40 levels, were assessed by ELISA. The rs3212227 minor allele (C) and homozygote genotype (CC) were more frequent in controls compared with patients with brucellosis (P = 0.006, OR = 0.608, 95%CI = 0.429-0.861 for the C allele; P = 0.024, OR = 0.443, 95% CI: 0.218-0.900 for the CC genotype). Comparison of IL-12B genotypes and serum levels of the IL-12p40 revealed that rs3212227 AA genotype, with higher frequency in patients than in controls, was associated with increased levels of the cytokine (P = 0.0001). Furthermore, the distribution of haplotype and genotype combinations in our study suggested that rs3212227C/rs6887695C haplotype or CC/GC or CC/CC genotype combinations may protect controls against Brucella infection by contributing to a functional downregulation of the serum IL-12p40 production in vivo, as shown by ELISA (P < 0.05). Overall, our study demonstrated that rs3212227 A variant was associated with higher levels of serum IL-12p40 and could possibly contribute to an inherited predisposition to brucellosis.

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Section: Discussionsupporting

confidence: 89%

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

et al. 2013

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Comprehensive analysis of cytokine gene polymorphisms defines the association of IL-12 gene with ophthalmopthy in Korean children with autoimmune thyroid disease

Jang

Cho

Baek

et al. 2016

Molecular and Cellular Endocrinology

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Association between rs6887695 and 3′-untranslated region polymorphisms within theinterleukin-12Bgene and susceptibility to autoimmune diseases in Asian and European population: A meta-analysis

et al. 2016

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No Association BetweenIL12BGene Polymorphisms and Graves’ Disease in the Chinese Population

Abstract: We conclude that these IL12B gene polymorphisms were not associated with sex bias in GD and do not confer susceptibility to Graves' disease (GD) in the Chinese population.

Cited by 3 publications

References 21 publications

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

Comprehensive analysis of cytokine gene polymorphisms defines the association of IL-12 gene with ophthalmopthy in Korean children with autoimmune thyroid disease

Association between rs6887695 and 3′-untranslated region polymorphisms within theinterleukin-12Bgene and susceptibility to autoimmune diseases in Asian and European population: A meta-analysis

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