No Association Between Gastric Fundic Gland Polyps and Gastrointestinal Neoplasia in a Study of Over 100,000 Patients

Background/Aims: The frequency of gastric polyps increases with the widespread use of endoscopy for diagnosis and treatment. As gastric polyps can be malignant or premalignant, histopathological evaluation is needed. The aim of this study is to determine the prevalence and characteristics of gastric polyps in patients undergoing endoscopy. Materials and Methods: This study consisted of a retrospective analysis of 36650 consecutive endoscopy and associated pathology reports of 29940 patients between December 2005 and February 2012 in a tertiary-referral center. Results: Gastric polypoid lesions were detected in 666 (2.22%) patients. Hyperplastic polyps were the most common type of polyps (36.2%), followed by fundic gland polyps (8.3%), inflammatory fibroid polyps (2.4%) and adenomatous polyps (1.9%). Foveolar hyperplasia, neuroendocrine tumor, xanthoma, gastrointestinal stromal tumor, adenocarcinoma and lymphoma were less commonly seen. Malignant transformation was seen in 0.42% of hyperplastic polyps and in 23.1% of adenomatous polyps. Conclusion: Endoscopic appearance of gastric polyps can be variable, distinguishing macroscopically can be misleading. Because of their malignant potential histopathological evaluation is mandatory and polypectomy should be performed whenever possible.

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Gastric polyps and polypoid lesions: Retrospective analysis of 36650 endoscopic procedures in 29940 patients

Vatansever¹,

Akpınar²,

Alper³

et al. 2015

“…In contrast to reports by Carmack et al (10) and Stolte et al (30), in which fundic gland polyps were reported as the most common gastric polyps, with a relative frequency of 77% and 47%, respectively, in our study, fundic gland polyps accounted for less than 6.1% of all polyps. Fundic gland polyps have almost no malignant potential when they are associated with the use of PPIs (11,31,32) or when they occur sporadically (33). Similarly, we found neither dysplasia nor malignancy in the fundic gland polyps in our study.…”

Section: Discussionsupporting

confidence: 44%

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Atalay

Solakoğlu²,

Sarı³

et al. 2020

Background/Aims: The aim of this study was to evaluate the gastric polyps detected by endoscopy in our institution with respect to their frequency, size, anatomic location, presence of dysplasia, and histopathologic features. Materials and Methods: Records of a total of 14,240 patients who underwent endoscopy between January 2008 and January 2012 were reviewed retrospectively. Of the 14,240 patients, 174 determined to have at least 1 histopathologically proven polyp were included in the study. Results: Three hundred eleven gastric polyps were found in 174/14,240 (1.2%) patients (1.79 polyps per patient). Gastric polyps were found most commonly in the antrum (41.5%). Of all gastric polyps, 189 (60.8%) were less than 1 cm. Histopathologically, the most common polyp type was hyperplastic (n: 261, 83.9%), followed by adenomatous (n: 23, 7.4%). Eight (34.8%) of the adenomatous polyps showed dysplasia, and in 4 (17.4%) of these cases, the dysplasia was high-grade. Nineteen (6.1%) of all gastric polyps were identified to be fundic gland polyps. Conclusion: According to this study from Turkey, the majority of polyps detected by endoscopy was solitary, smaller than 1 cm, and found in the antrum; furthermore, the most common type was a hyperplastic polyp.

“…However, Cao et al (2) reported that fundic gland polyps were the most common type of polyps; furthermore, they believed that there was no significant difference in inflammatory and hyperplastic polyps in males and females. A few studies stated that there were differences in the histological types of GPs, where fundic gland polyps were more common in females (1,16,17) and adenoma was more common in males (1). In the present study, the most common type of polyp was an inflammatory gastric polyp; secondary polyps were hyperplastic, fundic gland, and adenomatous polyps, with no gender difference.…”

Section: Discussionmentioning

confidence: 99%

Impact of gender and age on the occurrence of gastric polyps: data analysis of 69575 southeastern Chinese patients

Zheng¹,

Ni²,

Yu³

et al. 2015

Background/Aims: Current epidemiological data suggest that the incidence of gastric polyps (GP) is rare, and its etiology and pathogenesis are still not clear. This study analyzed and compared the occurrence and pathological types of GPs in southeast Chinese patients according to gender and age. Materials and Methods: This was a retrospective study of patients diagnosed with GP (n=2125) in Wenzhou People's Hospital (China) between January 2004 and December 2013. The relationships between the detection rate, the characteristics of GP, and the patients' demographic data were analyzed. Results: The detection rate of GP was 2.3% and 3.9% in males and females, respectively (p<0.01). The detection rate increased with increasing age in both genders. Polyps in the gastric antrum and gastric body were the most prevalent in both genders. Similarly, inflammatory polyps and hyperplastic polyps were the most prevalent in both genders. Hyperplastic polyps were more common in females than in males (28.6% vs. 24.2%, p<0.05), while there was no difference for inflammatory polyps, fundic GP, and adenoma (p>0.05). Age had no impact on the pathology of GP (p>0.05). Conclusions: The incidence of GPs was associated with gender and age.