No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)

Muller, David C.; Hodge, Allison; Fanidi, Anouar; Albanês, Demetrius; M., X.; Shu, Xiao‐Ou; Weinstein, Stephanie J.; Larose, Tricia L; Zhang, X.; Han, Jing; Stampfer, M. J.; Smith‐Warner, Stephanie A.; Ma, Jing; Gaziano, J. Michael; Sesso, Howard D.; Stevens, Victoria L.; McCullough, Marjorie L.; Layne, Tracy M.; Prentice, Ross L.; Pettinger, Mary; Thomson, Cynthia A.; Wang, Zheng; Gao, Yu‐Tang; Rothman, Nathaniel; Xiang, Yong‐Bing; Wang, R.; Yuan, Jian‐Min; Koh, Woon Puay; Butler, Lesley M.; Cai, Qiuyin; Blot, William J.; Wu, Jie; Ueland, Per Magne; Midttun, Øivind; Hveem, Kristian; Johansson, Mattias; Hultdin, Johan; Grankvist, Kjell; Arslan, Alan A.; Marchand, Loı̈c Le; Severi, Gianluca; Brennan, Paul

doi:10.1093/annonc/mdy104

Cited by 19 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, in NSCLC patients, the proportion of AC is approximately 41.7%. 2 The proportion in our study (84.3%) was much higher. This is largely because National Comprehensive Cancer Network clinical practice guidelines recommend routine testing for EGFR mutations in AC.…”

Section: Discussioncontrasting

confidence: 56%

“…Indeed, there were still some limitations to our study. First, in NSCLC patients, the proportion of AC is approximately 41.7% . The proportion in our study (84.3%) was much higher.…”

Section: Discussioncontrasting

confidence: 52%

“…Lung cancer is the most common cancer and the leading cause of cancer death in China . Non‐small cell lung cancer (NSCLC) is reported to account for up to 90% of all lung cancer cases . Mutation in the EGFR gene is the most common genetic event in NSCLC, especially in adenocarcinoma (AC) .…”

Section: Introductionmentioning

confidence: 99%

“…1 Non-small cell lung cancer (NSCLC) is reported to account for up to 90% of all lung cancer cases. 2 Mutation in the EGFR gene is the most common genetic event in NSCLC, especially in adenocarcinoma (AC). 3 Thus, EGFR is now one of the main targets of genotype-directed therapy for NSCLC.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development and validation of a model to predict tyrosine kinase inhibitor‐sensitive EGFR mutations of non‐small cell lung cancer based on multi‐institutional data

Chang

Liu

et al. 2018

Thoracic Cancer

View full text Add to dashboard Cite

BackgroundNon‐small cell lung cancer (NSCLC) with different EGFR mutation types shows distinct sensitivity to tyrosine kinase inhibitors (TKIs). This study developed a patho‐clinical profile‐based prediction model of TKI‐sensitive EGFR mutations.MethodsThe records of 1121 Chinese patients diagnosed with NSCLC from November 2008 to October 2014 (the development set) were reviewed. Multivariate logistic regression was conducted to identify any association between potential predictors and the classic sensitive EGFR mutations (exon 19 deletion and exon 21 L858R point mutation). A prediction index was created by assigning weighted scores to each factor proportional to a regression coefficient. Validation was made in an independent cohort consisting of 864 patients who were consecutively enrolled between November 2014 and January 2017 (the validation set).ResultsSeven independent predictors were identified: gender (female vs. male), adenocarcinoma (yes vs. no), smoking history (no vs. yes), N stage (N+ vs. N0), M stage (M1 vs. M0), brain metastasis (yes vs. no), and elevated Cyfra 21‐1 (no vs. yes). Each was assigned a number of points. In the validation set, the area under curve of the prediction index appeared as 0.698 (95% confidence interval 0.663–0.733). The sensitivity, specificity, positive and negative predictive values, and concordance were 95.0%, 32.3%, 61.4%, 85.1%, and 65.6%, respectively.ConclusionWe developed a patho‐clinical profile‐based model for predicting TKI‐sensitive EGFR mutations. Our model may represent a noninvasive, economical choice for clinicians to inform TKI therapy.

show abstract

Section: Discussioncontrasting

confidence: 56%

“…Indeed, there were still some limitations to our study. First, in NSCLC patients, the proportion of AC is approximately 41.7% . The proportion in our study (84.3%) was much higher.…”

Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development and validation of a model to predict tyrosine kinase inhibitor‐sensitive EGFR mutations of non‐small cell lung cancer based on multi‐institutional data

Chang

Liu

et al. 2018

Thoracic Cancer

View full text Add to dashboard Cite

show abstract

“…It is suggested in some studies that vitamin D may contribute to the protection from cancer and this theory was based on the vitamin D receptor (VDR) sites in several cancer cells and researchers believe that the vitamin can block the growth of malignant cells and promote their transformation into non-malignant cells and some studies claimed that vitamin D can regulate certain cell processes such as cell proliferation in which, 1a,25 (OH)2D3, which is the active metabolite of vitamin D eliminates cell proliferation [15]. It can regulate other processes as well such as differentiation, and inhibition of angiogenesis and some studies confirm the assumption that this vitamin could have an impact in lowering the risk of cancer [16,17].…”

Section: Vitamin D and Different Malignanciesmentioning

confidence: 94%

Vitamin D Impact on Human Health and Its Relation With Several Diseases

et al. 2018

View full text Add to dashboard Cite

Vitamins are organic nutrients and substances that are needed for many biochemical functions. They are one of the six essential elements required for human life. Vitamin D is also known among the public as the Sunshine vitamin, as it is produced internally within the human body when exposed to sunlight and it is well known that the big majority of United Arab Emirates (UAE) population suffer from its deficiency.They are usually not found inside the body and therefore must be eaten from food or taken by supplements. Vitamin D that is obtained from diet or body synthesis when it is exposed to sufficient sunlight is biologically inactive without the enzymatic activation that converts it into its active form in the liver and kidney.Deficiency of vitamin D could lead to many troubling diseases such as depression including seasonal affective disorder, Parkinson’s disease, Alzheimer’s disease, Arthritis (gout, osteoarthritis, tendonitis), Osteoporosis, gum and teeth diseases, obesity, diabetes, heart diseases, metabolic syndromes, immunity related diseases (sclerosis, erythematosis), and cancer, which will be discussed in this review. The main objective of the current review is to evaluate the associations of vitamin D with the diverse health outcomes according to the latest studies done so far.

show abstract

Vitamin D, cancer, and dysregulated phosphate metabolism

Brown

2019

Endocrine

View full text Add to dashboard Cite

No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)

Abstract: This study did not support an association between vitamin D concentrations and lung cancer risk.

Cited by 19 publications

References 11 publications

Development and validation of a model to predict tyrosine kinase inhibitor‐sensitive EGFR mutations of non‐small cell lung cancer based on multi‐institutional data

Development and validation of a model to predict tyrosine kinase inhibitor‐sensitive EGFR mutations of non‐small cell lung cancer based on multi‐institutional data

Vitamin D Impact on Human Health and Its Relation With Several Diseases

Vitamin D, cancer, and dysregulated phosphate metabolism

Contact Info

Product

Resources

About