No association between brain-derived neurotrophic factor gene and obsessive-compulsive disorder

Zai, Gwyneth; Arnold, Paul; Strauss, John S.; King, Nicole; Burroughs, Eliza; Richter, Margaret A.; Kennedy, James L.

doi:10.1097/00041444-200512000-00002

Cited by 26 publications

(16 citation statements)

References 6 publications

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“…A report by Katerberg et al [2009] has suggested that in females, the BDNF Met/Met genotype may be associated with a late-onset form of OCD and the BDNF Val/Val genotype with a more severe form of OCD. Other studies did not find an association with symptom dimensions [Hall et al, 2003;Zai et al, 2005;Wendland et al, 2007;Alonso et al, 2008].…”

Section: Discussionmentioning

confidence: 79%

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Tükel

Gürvit

Özata

et al. 2012

American J of Med Genetics Pt B

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In the present study, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism is associated with obsessive-compulsive disorder (OCD) and also investigated the association between the BDNF Val66Met polymorphism and the performance on tests measuring executive functions in a sample of patients with OCD. A total of 100 patients diagnosed with OCD according to DSM-IV criteria and 110 control subjects were included in this study. Single nucleotide polymorphism (G/A) leading to Val to Met substitution at codon 66 in BDNF was screened in the DNA samples of all participants. The genotype frequencies of BDNF Val66Met polymorphism were compared in OCD patients and healthy controls. The four subgroups of OCD and healthy control subjects, determined according to being Val homozygous or carrying a Met allele, were also compared according to their performance in a battery of neuropsychological tests of executive functions and verbal memory. There was no significant difference for the allele and genotype distributions of BDNF Val66Met polymorphism between the OCD and healthy control groups. Compared to the other three subgroups, OCD-Met carriers were slower on Trail-Making Test part A (TMT A), part B (TMT B) score and its speed-corrected score (TMT B-A). OCD-Met carriers had also poor performance on verbal fluency tasks and several CVLT measures compared only to the healthy control-Met carriers. These results demonstrate that the BDNF Val66Met polymorphism does not appear to be a risk factor for OCD. However, the presence of a BDNF Met allele, which is a known attenuator of BDNF activity, may be associated with a poorer executive functioning in OCD.

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Section: Discussionmentioning

confidence: 79%

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Tükel

Gürvit

Özata

et al. 2012

American J of Med Genetics Pt B

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“…Early onset seems to be linked to more severe OCD [Sobin et al, 2000;Fontenelle et al, 2003]. Other studies in which no association was found between the BDNF Val66Met variant and age of onset [Zai et al, 2005;Wendland et al, 2007] had the drawback that smaller samples were used which might have hampered power to detect between-group differences.…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, seven studies have reported on the BDNF Val66Met variant in OCD, using either a family based approach [Hall et al, 2003;Mossner et al, 2005;Zai et al, 2005;Dickel et al, 2007], or a case-control design [Wendland et al, 2007;Alonso et al, 2008;Hemmings et al, 2008]. These studies are summarized in Table I.…”

Section: Introductionmentioning

confidence: 99%

“…One family based study using haplotype analysis found a haplotype marked by the BDNF Met66 allele to be undertransmitted and therefore likely to confer a protective effect against OCD [Hall et al, 2003], whereas another family based study found a haplotype including the BDNF Val66 allele to be associated with a reduced risk for OCD . Some studies also investigated the association of the BDNF Val66Met genotype and dimensional OC phenotypes such as symptom dimensions, age of onset and symptom severity [Hall et al, 2003;Zai et al, 2005;Wendland et al, 2007;Alonso et al, 2008]. One study found an association of the BDNF Met66 allele with earlier age of onset in males and the BDNF Val66Met genotype with increased severity in women , whereas other studies did not find an association with these dimensional phenotypes.…”

Section: Introductionmentioning

confidence: 99%

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The role of the brain‐derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive‐compulsive disorder (OCD)

Katerberg

Löchner

Cath

et al. 2009

American J of Med Genetics Pt B

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Evidence suggests that the Val66Met variant of the brain-derived neurotrophic factor (BDNF) gene may play a role in the etiology of Obsessive-Compulsive Disorder (OCD). In this study, the role of the BDNF Val66Met variant in the etiology and the phenotypic expression of OCD is investigated. Associations between the BDNF Val66Met variant and OCD, obsessive-compulsive symptom dimensions, Yale-Brown Obsessive Compulsive Scale (YBOCS) severity scores, age of onset and family history of obsessive-compulsive symptoms were assessed. The BDNF Val66Met variant was genotyped in 419 patients with sub-/clinical OCD and 650 controls. No differences in allele or genotype frequency were observed between cases and controls. In females with OCD, the Met66Met genotype was associated with later age of onset and a trend for a negative family history, whereas the Val66Val genotype was associated with a trend for lower YBOCS severity scores. Item-level factor analysis revealed six factors: 1) Contamination/cleaning; 2) Aggressive obsessions/checking; 3) Symmetry obsessions, counting, ordering and repeating; 4) Sexual/religious obsessions; 5) Hoarding and 6) Somatic obsessions/checking. A trend was found for a positive association between Factor 4 (Sexual/religious obsessions) and the BDNF Val66Val genotype. The results suggest that BDNF function may be implicated in the mediation of OCD. We found that for the BDNF Met66Met genotype may be associated with a milder phenotype in females and a possible role for the BDNF Val66Val genotype and the BDNF Val66 allele in the sexual/religious obsessions.

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“…Family-based studies found that Val66Met variation was strongly associated with OCD, suggesting that the rare Met66 allele conferred a protective effect in OCD (Hall et al, 2003). However, the results of those following genetic studies exploring the relationship of BDNF and OCD have been inconsistent (Hemmings et al, 2008;Katerberg et al, 2009;Zai et al, 2005).The study of GAD found that there was no significant association between Val66Met and antidepressant treatment response in GAD patients (Narasimhan et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder

Wang

Zhang

Liu

et al. 2015

Journal of Affective Disorders

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No association between brain-derived neurotrophic factor gene and obsessive-compulsive disorder

Cited by 26 publications

References 6 publications

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

The role of the brain‐derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive‐compulsive disorder (OCD)

BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder

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