No association between blood telomere length and longitudinally assessed diet or adiposity in a young adult Filipino population

Bethancourt, Hilary J.; Kratz, Mario; Beresford, Shirley A.A.; Hayes, M. Geoffrey; Kuzawa, Christopher W.; Duazo, Paulita; Borja, Judith B.; Eisenberg, Dan T. A.

doi:10.1007/s00394-015-1080-1

Cited by 22 publications

(15 citation statements)

References 105 publications

(168 reference statements)

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“…Another study on 840 adults indicated that the consumption of processed meat was inversely associated with TL ( Nettleton et al, 2008 ). In the study of Betancourt et al, processed meat, grilled meat, oil, and beverages were associated with shorter TL ( Bethancourt, 2014 ). Per other studies, high intake of processed meat leads to the formation of inflammatory mediator compounds and increases the risk of numerous cancers such as breast cancer ( Cho et al, 2006 ), diabetes ( Pan et al, 2011 ) and cardiovascular diseases (CVD) ( Micha, Wallace, & Mozaffarian, 2010 ).…”

Section: Discussionmentioning

confidence: 93%

“…In another study, a direct relationship was reported between the consumption of fruits and TL in men, but this relationship was not identified in women ( Tiainen et al, 2012 ). Another study reported that the consumption of fish, fruits and vegetables are positively associated with TL ( Bethancourt, 2014 ). But some studies such as Gu et al ( Gu et al, 2015 ) and several other studies reported no significant relationship between vegetables and/or fruits and TL ( Gu et al, 2015 ; Tiainen et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

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Foods, Dietary Patterns and Occupational Class and Leukocyte Telomere Length in the Male Population

et al. 2017

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Telomeres contain TTAGGG repetitive sequences and are located at the end of human chromosomes. Telomere dysfunction is associated with some age-related and chronic diseases, but its relationship with foods, dietary patterns, and occupational class in the young male population is not yet known. In this cross-sectional study, 300 healthy men, residents of Tehran, aged 25–40 years were enrolled from January to December 2016. We employed a cross-sectional study of 300 healthy people, residents of Tehran, aged 25-40 years. A food frequency questionnaire was used to obtain food intakes of all participants and converted into actual food intake (g/day). The principal components analysis was used to determine dietary patterns and other demographic characteristics. Leukocyte telomere length (TL) was measured by quantitative real-time polymerase chain reaction (PCR) to measure number of telomere repeat copy number (T) to the relative number of 36B4 copies (S) (T/S ratio). T/S in office-workers, waste recyclers, and other workers were 1.22 ± 0.4, 1.08 ± 0.3, and 1.094 ± 0.34, respectively. The results of multivariate linear regression adjusted for age, body mass index (BMI), and smoking were showed that whole grains (β = 0.02; p = .05), refined grains, fruits and vegetables, fish and dairy products were associated with an increase in log-T/S, but consumption of nuts and seeds (β = −0.00072; p = .06), meats (β = −0.00043; p = .9), produced meats (β = −0.00238; p = .03), oils and solid fats (β = −0.00146; p = .03) had a negative relationship with log-T/S in all studied occupational classes. A positive relationship was reported between the healthy (β = 0.017; p = .2) and traditional dietary pattern (β = 0.012; p = .4) with log-T/S, but western pattern identified negative relationship (β = −0.004; p = .7). Adherence to a healthy (with consumption whole grains, refined grains, dairy, and cereals) and then traditional pattern with increased consumption of fruits, vegetables and whole grains, fish and dairy products are necessary to prevent TL destruction in all studied occupational classes.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Foods, Dietary Patterns and Occupational Class and Leukocyte Telomere Length in the Male Population

et al. 2017

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“…The derivation of these PCs have been described previously (Croteau‐Chonka et al, ; Croteau‐chonka et al, ; Wu et al, ). As in previous analyses (Bethancourt et al, ; D. Eisenberg et al, ; Ryan et al, ), the bivariate association between the first 10 PCs and TL were tested. The top PCs up to and including the last one showing a significant bivariate association with TL (10 total) were retained as control variables.…”

Section: Methodsmentioning

confidence: 99%

Early life growth and adult telomere length in a Filipino cohort study

Masterson

Hayes

Kuzawa

et al. 2019

American J Hum Biol

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Objective: We investigated the relationship between early life growth patterns and blood telomere length (TL) in adulthood using conditional measures of lean and fat mass growth to evaluate potentially sensitive periods of early life growth. Methods: This study included data from 1562 individuals (53% male; age 20-22 years) participating in the Cebu Longitudinal Health and Nutrition Survey, located in metropolitan Cebu, Philippines. Primary exposures included length-forage z-score (HAZ) and weight-for-age z-score (WAZ) at birth and conditional measures of linear growth and weight gain during four postnatal periods: 0-6, 6-12, and 12-24 months, and 24 months to 8.5 years. TL was measured at~21 years of age. We estimated associations using linear regression. Results: The study sample had an average gestational age (38.5 ± 2 weeks) and birth size (HAZ = -0.2 ± 1.1, WAZ = -0.7 ± 1.0), but by age 8.5 years had stunted linear growth (HAZ = -2.1 ± 0.9) and borderline low weight (WAZ = -1.9 ± 1.0) relative to World Health Organization references. Heavier birth weight was associated with longer TL in early adulthood (P = .03), but this association was attenuated when maternal age at birth was included in the model (P = .07). Accelerated linear growth between 6 and 12 months was associated with longer TL in adulthood (P = .006), whereas weight gain between 12 and 24 months was associated with shorter TL in adulthood (P = .047). Conclusions: In Cebu, individuals who were born heavier have longer TL in early adulthood, but that birthweight itself may not explain the association. Findings suggest that childhood growth is associated with the cellular senescence process in adulthood, implying early life well-being may be linked to adult health.

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“…The derivation of these principal components have been described previously (Wu et al, 2011; Croteau-Chonka et al, 2012; Croteau-Chonka et al, 2011). As in previous analyses (Bethancourt et al, 2015), the bivariate association between the first ten principal components and TL were tested. The top principal components up to and including the last one showing a significant bivariate association with TL were retained as control variables.…”

Section: Methodsmentioning

confidence: 99%

Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the Philippines

Eisenberg

Borja

Hayes

et al. 2017

American J Hum Biol

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Objectives Telomeres are repetitive DNA at chromosomes ends that shorten with age due to cellular replication and oxidative stress. As telomeres shorten, this can eventually place limits on cell replication and contribute to senescence. Infections are common during early development and activate cellular immune responses that involve clonal expansion and oxidative stress. As such, a high infectious disease burden might shorten blood telomere length (BTL) and accelerate the pace of immune senescence. Methods To test this, BTL measured in young adults (21.7 ± 0.3 years old) from the Philippines (N=1,759) were linked to prospectively collected early life data on infectious burden. Results As predicted, increased early life diarrheal prevalence was associated with shorter adult BTL. The association was most marked for infections experienced from 6–12 months, which corresponds with weaning and maximal diarrheal burden. A standard deviation increase in infections at 6–12 m predicts a 45 bp decrease in BTL, equivalent to 3.3 years of adult telomeric aging in this population. Contrary to expectations, breastfeeding duration was not associated with BTL, nor did effects vary by sex. Conclusions These findings show that infancy diarrheal disease predicts a marker of cellular aging in adult immune cells. These findings suggest that early life infectious burden may influence late life health, or alternatively, that short TL in early life increases infectious disease susceptibility.

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No association between blood telomere length and longitudinally assessed diet or adiposity in a young adult Filipino population

Cited by 22 publications

References 105 publications

Foods, Dietary Patterns and Occupational Class and Leukocyte Telomere Length in the Male Population

Foods, Dietary Patterns and Occupational Class and Leukocyte Telomere Length in the Male Population

Early life growth and adult telomere length in a Filipino cohort study

Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the Philippines

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