No association between atopic dermatitis and acne vulgaris in the general population

Halling, Anne‐Sofie; Jemec, Gregor B. E.; Linneberg, Allan; Thyssen, Jacob P.

doi:10.1111/jdv.17040

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…Results from a recent study indicated that there is no relationship between acne incidence and AD. 19 Together, these data suggest that patients who are younger, have a history of acne, are female, or are non-White may have an increased of acne, regardless of treatment.…”

Section: Discussionmentioning

confidence: 84%

Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: A post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials

Mendes‐Bastos

Ladizinski

Guttman‐Yassky

et al. 2022

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 84%

Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: A post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials

Mendes‐Bastos

Ladizinski

Guttman‐Yassky

et al. 2022

Journal of the American Academy of Dermatology

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“…Few studies have previously examined the co‐occurrence of AD and acne. A small survey of 482 15‐ to 41‐year‐old Danes from the general population found no statistically significant association between the two conditions, and showed that acne was located at the same anatomical sites in cases and controls 2 . Overall, the life‐time prevalence of any acne was reported by 71% of AD patients, equally common in women and men, and 41% reported that they considered acne to have been a problem.…”

Section: Discussionmentioning

confidence: 99%

“…There is currently very little insight into the risk of acne in patients with atopic dermatitis (AD). 2 However, clinical trials of upadacitinib and abrocitinib in moderate-to-severe AD, both Janus kinase (JAK) 1 inhibitors, documented very high absolute numbers of acne in adolescent and adults. While the pathomechanism is currently unclear, there is a need for more knowledge about the risk and severity of acne in patients with AD.…”

Section: Introductionmentioning

confidence: 99%

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Incidence, prevalence and risk of acne in adolescent and adult patients with atopic dermatitis: a matched cohort study

Thyssen

Maul

Schmid‐Grendelmeier

et al. 2022

Acad Dermatol Venereol

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Background Use of Janus kinase 1 inhibitors in moderate‐to‐severe atopic dermatitis (AD) is associated with incident acne in adolescent and adults that is mostly mild, transient and treatable. There is a need for more knowledge about the risk and severity of acne in patients with AD. Objectives To examine the prevalence, incidence and risk of acne in adolescents and adults with AD using nationwide prescription data. Methods A matched cohort study of 6600 adults with AD and 66 000 controls was conducted using routinely and prospectively collected nationwide administrative data. Adjusted hazard ratios (HR) are reported with 95% confidence intervals (CIs). Results The 12‐month prevalence of acne was 3.7% in the general population and 3.9% among AD patients. The incidence rate of acne was highest among 12‐ to 18‐year‐old AD patients, and overall slightly higher in women with AD compared with males. The overall risk in patients with AD was similar with that of the general population (HR 0.96; 95% CI 0.88–1.06), whereas the risk of being treated for severe acne was reduced in AD patients (HR 0.59; 95% CI 0.47–0.73) and mainly among adolescents and young adults. The HR of acne increased with age reaching 1.41 (95% CI 1.07–1.87) for ages 30–39 years, and 2.07 (95% CI 1.42–3.03) for patients ≥40 years compared with controls. Conclusions The risk and severity of acne in AD patients change with age and sex, which may be used for the risk assessment of acne following treatment with Janus kinase 1 inhibitors.

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“…A recent study concluded that individuals with AD have the same prevalence of AV as non-AD individuals [9]. Considering the different pathogenesis of these clinical conditions and given the high morbidity associated with atopic dermatitis and acne in pediatric population, our aim was to investigate if adolescents with AV have different expressions of AD and the impact in quality of life of both diseases.…”

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confidence: 99%

Atopic dermatitis in adolescents with acne vulgaris

Costa

Tapadinhas

Sampaio

2023

Eur Ann Allergy Clin Immunol

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Atopic dermatitis (AD) is a chronic skin disease characterized by severe pruritus, erythema, edema, crusting, excoriation, lichenification and skin dryness. AD is often diagnosed during childhood, though the onset of symptoms may occur at any time. Lesions in older children and adults are usually located in flexural areas along with the head and neck. Facial involvement is also common in AD, not only in children but additionally in adolescents [1]. This inflammatory disease is characterized by skin microbial dysbiosis and barrier dysfunction. Initial inflammation has a T2 profile in response to allergens, which is later amplified by skin barrier breaking and reduction of antimicrobial peptides. This promotes skin pathogens growth (mainly Staphylococcus aureus) and the evolution to a T2, T1 and T17 pattern [2,3]. AD is often associated with other atopic diseases such as rhinitis and asthma.

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No association between atopic dermatitis and acne vulgaris in the general population

Cited by 5 publications

References 6 publications

Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: A post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials

Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: A post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials

Incidence, prevalence and risk of acne in adolescent and adult patients with atopic dermatitis: a matched cohort study

Atopic dermatitis in adolescents with acne vulgaris

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