No. 346-Advanced Reproductive Age and Fertility

Liu, Kimberly; Case, Allison

doi:10.1016/j.jogc.2016.12.004

Cited by 39 publications

(36 citation statements)

References 79 publications

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“…Fecundability is the ability to achieve a pregnancy within a menstrual cycle. This effect is also similar in women undergoing ART with decreased pregnancy rates with age (Liu et al, 2017).…”

Section: Delayed Child Bearing /Age Of Starting a Familysupporting

confidence: 53%

Effects of lifestyle factors on fertility: practical recommendations for modification

Emokpae

Brown

2021

Reproduction and Fertility

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The role that lifestyle factors play in fertility issues has generated some amount of interest and questions among stakeholders. This review aims to highlight the impact of lifestyle behaviors on the fertility potential of an individual and what can be done to prevent or improve reproductive outcomes. Relevant published articles on the effect of lifestyle behaviors were obtained from Medline, Pubmed and Google scholar search engines for the study. The review of the literature indicates a negative impact of modifiable lifestyle factors such as fat-rich diets, delayed childbearing/age of starting family, smoking, alcohol misuse, sexual behavior, anxiety/depression and perception/beliefs were associated with fertility. The ensuing stress precipitates social behaviors such as excessive alcohol and caffeine consumption, tobacco smoking, misuse of recreational drugs/medications, which increases the risk of sexually transmitted diseases and infection leading to infertility. Practical recommendations to modify lifestyle behaviors and the impact of misconception of Assisted Reproductive Technology in the treatment of infertility are discussed. The need to make appropriate behavioral changes to stem the tide of infertility in Nigeria is imperative. More reproductive health education is needed to create the necessary awareness of the etiologies of infertility and the importance of in vitro fertilization treatment as a means of conceiving ‘natural’ babies is suggested. Lay summary Scientific evidence has suggested that modifiable lifestyle factors (consumption fat-rich diets, delayed childbearing/age of starting family, smoking, alcohol misuse, sexual behavior, anxiety/depression and perception/beliefs) play important roles in the general health and wellbeing of individuals including fertility. Evidence exists of an association between lifestyle behaviors and infertility in both men and women. Understanding the various processes through which modifiable lifestyle behaviors impair fertility will help to assist in the management of affected individuals. We conducted a comprehensive review of published studies to assess how lifestyle factors inhibit fertility and practical ways to ameliorate them. This review also deals with the misconception of Assisted Reproductive Technology in the treatment of infertility. The need to make appropriate behavioral changes to stem the tide of infertility in Nigeria is imperative. More reproductive health education is needed to create the necessary awareness of the causes of infertility and the importance of in vitro fertilization in the treatment of infertility.

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Section: Delayed Child Bearing /Age Of Starting a Familysupporting

confidence: 53%

Effects of lifestyle factors on fertility: practical recommendations for modification

Emokpae

Brown

2021

Reproduction and Fertility

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“…On the one hand, the development of assisted reproduction technologies (ART) has made it possible for individuals who would have previously suffered from childlessness, such as individuals with fecundity problems due to advanced age or medical problems, single women, or same-sex couples to experience parenthood with the help of artificial insemination, IVF and surrogate motherhood (Bartels, 2004;Blaževičienė et al, 2014;Hudson et al, 2009). Although technological options can help to a degree with age-related fertility issues, they cannot completely compensate for the drop in fertility (Leridon, 2004;Liu and Case, 2017).…”

Section: Introductionmentioning

confidence: 99%

What shapes public attitudes towards assisted reproduction technologies in Europe?

Szalma¹,

Djundeva²

2020

DEE

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By examining attitudes on assisted reproduction technologies (ART) in 42 European countries, we highlight individual and country-level factors that are associated with the level of social acceptance or rejection of ART. This paper contributes to the literature on social acceptance of artificial insemination and in-vitro fertilization, the two most prominent examples of ART in Europe, and directs attention to several previously under-researched aspects. The empirical base of this study is the fourth round of the European Values Study, conducted in 2008-2010. Using a multilevel random-intercept linear regression model, we examine the impact of several individual-and country-level characteristics on the agreement level with the statement that artificial insemination or in-vitro fertilization can always be justified, never be justified or it is evaulated in a mixed manner. According to our findings, there are strong relationships between attitudes towards ART and socio-demographic variables, as well as religiousness and some individual attitudes, including those related to traditional family formation practices, "justification for homosexuality", (non-)preference for homosexual neighbors and acceptance of adoption by homosexual couples. For country-level characteristics we find significant association only in the case of mean age at first birth of women. We do not find a significant relationship between attitudes towards ART and country-level variables such as GDP, religiosity and same-sex couples' access to ART.

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“…This is also the case globally, as women over 35 years old undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatments now represent the most rapidly growing population [ 3 – 5 ]. However, whether the age-related decline in fertility can be compensated by IVF/ICSI is still controversial as age is the most determinant of oocyte quantity and quality [ 6 , 7 ]. Since IVF/ICSI is an expensive and time-consuming treatment procedure without being covered by the health insurance in many countries, the chance of success should be carefully discussed with AMA patients before treatment initiation.…”

Section: Introductionmentioning

confidence: 99%

Can repeat IVF/ICSI cycles compensate for the natural decline in fertility with age? an estimate of cumulative live birth rates over multiple IVF/ICSI cycles in Chinese advanced-aged population

Ruan

Luo

et al. 2021

Aging

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In order to find out to what extent ovarian aging could be compensated by the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatments, a total of 4102 women above the age of 35 undergoing 6489 complete cycles from 2009 to 2015 with follow-up visits until 2017 were retrospectively analyzed. Cumulative live birth rates (CLBRs) across multiple IVF/ICSI cycles were compared in the study population stratified by age and ovarian reserve (classified by the POSEIDON criteria). Younger patients (aged between 35 and 40) could well benefit from repeat IVF treatments, with the optimal CLBRs ranging from 62%-72% for up to four complete cycles. However, the CLBRs sharply declined to 7.7%-40% in older patients (>40yrs). In light of ovarian reserve, the optimal-estimated-four-cycle CLBR of younger patients (35-40yrs) in POSEIDON group 2 could approached to those with normal ovarian response (non-POSEIDON), with 57.3%-70% versus 74.5%-81% respectively. However, the CLBR of older patients (>40yrs) in POSEIDON group 2 only reached 50% of their counterparts. Extending the number of IVF cycles beyond three or four is effective for advanced-aged women, especially in younger normal responders (non-POSEIDON) and unexpected poor/suboptimal responders (POSEIDON group 2). The real turning point at which female fecundity dropped after multiple IVF cycles is at the age of 40.

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No. 346-Advanced Reproductive Age and Fertility

Cited by 39 publications

References 79 publications

Effects of lifestyle factors on fertility: practical recommendations for modification

Effects of lifestyle factors on fertility: practical recommendations for modification

What shapes public attitudes towards assisted reproduction technologies in Europe?

Can repeat IVF/ICSI cycles compensate for the natural decline in fertility with age? an estimate of cumulative live birth rates over multiple IVF/ICSI cycles in Chinese advanced-aged population

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