1991
DOI: 10.1023/a:1015854118110
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Abstract: The pharmacokinetics of valproic acid (VPA) were compared in dogs with those of the prodrugs ethyl valproate (E-VPA), trichloroethyl valproate (T-VPA), and valproyl valproate (V-VPA). Valproic acid, E-VPA, T-VPA, and V-VPA were administered intravenously and orally to six dogs at equimolar doses. The three VPA prodrugs were rapidly converted to VPA. The biotransformation was complete in the case of E-VPA and T-VPA but was only partial in the case of V-VPA. Because of the rapid conversion to the parent drug, af… Show more

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Cited by 15 publications
(2 citation statements)
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“…Introduction of a double bond at C-2 (2-ene-VPA) led to improved anticonvulsant activity . In addition to the modifications of the aliphatic moiety of VPA, several valproic acid ester derivatives have been tested .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Introduction of a double bond at C-2 (2-ene-VPA) led to improved anticonvulsant activity . In addition to the modifications of the aliphatic moiety of VPA, several valproic acid ester derivatives have been tested .…”
Section: Introductionmentioning
confidence: 99%
“…In addition to the modifications of the aliphatic moiety of VPA, several valproic acid ester derivatives have been tested . Recently, several ester derivatives of VPA with sugar alcohols have been synthesized and some were found to be active as anticonvulsants .…”
Section: Introductionmentioning
confidence: 99%