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Burow, Gloria; Gardner, Harold W.; Keller, Nancy P.

doi:10.1023/a:1006361305703

Cited by 74 publications

(23 citation statements)

References 26 publications

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“…The trypsin protein inhibitor 1 (CL516Contig1) was demonstrated to be resistant to A. flavus infection in corn [24,25,26,27]. The lipoxygenase (CL121Contig1) also showed anti-fungal activities in peanut, corn, and soybean [28,29,30,31]. Several lines of evidence have indicated that lipoxygenase enzymes and their products, especially 9S- and 13S-hydroperoxy fatty acids, could play a role in the Aspergillus /seed interaction.…”

Section: Resultsmentioning

confidence: 99%

Gene Expression Profiling and Identification of Resistance Genes to Aspergillus flavus Infection in Peanut through EST and Microarray Strategies

Guo

Fedorova

Chen

et al. 2011

Toxins

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Aspergillus flavus and A. parasiticus infect peanut seeds and produce aflatoxins, which are associated with various diseases in domestic animals and humans throughout the world. The most cost-effective strategy to minimize aflatoxin contamination involves the development of peanut cultivars that are resistant to fungal infection and/or aflatoxin production. To identify peanut Aspergillus-interactive and peanut Aspergillus-resistance genes, we carried out a large scale peanut Expressed Sequence Tag (EST) project which we used to construct a peanut glass slide oligonucleotide microarray. The fabricated microarray represents over 40% of the protein coding genes in the peanut genome. For expression profiling, resistant and susceptible peanut cultivars were infected with a mixture of Aspergillus flavus and parasiticus spores. The subsequent microarray analysis identified 62 genes in resistant cultivars that were up-expressed in response to Aspergillus infection. In addition, we identified 22 putative Aspergillus-resistance genes that were constitutively up-expressed in the resistant cultivar in comparison to the susceptible cultivar. Some of these genes were homologous to peanut, corn, and soybean genes that were previously shown to confer resistance to fungal infection. This study is a first step towards a comprehensive genome-scale platform for developing Aspergillus-resistant peanut cultivars through targeted marker-assisted breeding and genetic engineering.

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Section: Resultsmentioning

confidence: 99%

Gene Expression Profiling and Identification of Resistance Genes to Aspergillus flavus Infection in Peanut through EST and Microarray Strategies

Guo

Fedorova

Chen

et al. 2011

Toxins

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“…This latter point is of significance as many Aspergillus spp. are seed infesting fungi that elicit hydroperoxy linoleic acid production in higher plants (33). The sporogenic response to linoleic acid moieties requires the presence of an intact veA gene.…”

Section: Discussionmentioning

confidence: 99%

Genetic Connection between Fatty Acid Metabolism and Sporulation in Aspergillus nidulans

Calvo¹,

Gardner²,

Keller³

2001

Journal of Biological Chemistry

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167

168

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In the Ascomycete fungus Aspergillus nidulans, the ratio of conidia (asexual spores) to ascospores (sexual spores) is affected by linoleic acid moieties including endogenous sporogenic factors called psi factors. Deletion of odeA (⌬odeA), encoding a ⌬-12 desaturase that converts oleic acid to linoleic acid, resulted in a strain depleted of polyunsaturated fatty acids (18:2 and 18:3) but increased in oleic acid (18:1) and total percent fatty acid content. Linoleic acid-derived psi factors were absent in this strain but oleic acid-derived psi factors were increased relative to wild type. The ⌬odeA strain was reduced in conidial production and mycelial growth; these effects were most noticeable when cultures were grown at 26°C in the dark. Under these environmental conditions, the ⌬odeA strain was delayed in ascospore production but produced more ascospores than wild type over time. This suggests a role for oleic acid-derived psi factors in affecting the asexual to sexual spore ratio in A. nidulans. Fatty acid composition and spore development were also affected by veA, a gene previously shown to control light driven conidial and ascospore development. Taken together our results indicate an interaction between veA and odeA alleles for fatty acid metabolism and spore development in A. nidulans.

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“…Aspergillus infection alters plant LOX gene expression in corn (Wilson et al ., 2001) and in peanut (Burow et al ., 2000; Tsitsigiannis et al ., 2005b) through the action of ppo genes (Fig. 2) (Brodhagen et al ., 2008).…”

Section: Oxylipin Signaling In Fungal/host Interactionsmentioning

confidence: 99%

Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity

Fischer

Keller

2016

J Microbiol.

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Oxylipins are a class of molecules derived from the incorporation of oxygen into polyunsaturated fatty acid substrates through the action of oxygenases. While extensively investigated in the context of mammalian immune responses, over the last decade it has become apparent that oxylipins are a common means of communication among and between plants, animals, and fungi to control development and alter host-microbe interactions. In fungi, some oxylipins are derived non-enzymatically while others are produced by lipoxygenases, cyclooxygenases, and monooxygenases with homology to plant and human enzymes. Recent investigations of numerous plant and human fungal pathogens have revealed oxylipins to be involved in the establishment and progression of disease This review highlights oxylipin production by pathogenic fungi and their role in fungal development and pathogen/host interactions.

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Untitled

Cited by 74 publications

References 26 publications

Gene Expression Profiling and Identification of Resistance Genes to Aspergillus flavus Infection in Peanut through EST and Microarray Strategies

Gene Expression Profiling and Identification of Resistance Genes to Aspergillus flavus Infection in Peanut through EST and Microarray Strategies

Genetic Connection between Fatty Acid Metabolism and Sporulation in Aspergillus nidulans

Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity

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