NMR technique and methodology in botanical health product analysis and quality control

Zhao, Jianping; Wang, Mei; Seethapathy, Gopalakrishnan Saroja; Khan, Ikhlas A.

doi:10.1016/j.jpba.2021.114376

Cited by 20 publications

(9 citation statements)

References 223 publications

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“…For herbal extracts not yet included in pharmacopoeias, these methods are essential to define a chemical fingerprint according to the state-of-the-art. However, since every detection method has its intrinsic shortcomings ( Upton et al, 2020 ; Zhao et al, 2022 ), using just one method may result in detecting only a subset of constituents, leaving a large share of substances undetected. For example, thin-layer chromatography only visualizes substances that are either intrinsically fluorescent or absorbent, or, if a staining reagent was used, only substances that react accordingly.…”

Section: Resultsmentioning

confidence: 99%

Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12

Heinrich¹,

Jalil²,

Abdel‐Tawab

et al. 2022

Front. Pharmacol.

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Background: Research on medicinal plants and extracts derived from them differs from studies performed with single compounds. Extracts obtained from plants, algae, fungi, lichens or animals pose some unique challenges: they are multicomponent mixtures of active, partially active and inactive substances, and the activity is often not exerted on a single target. Their composition varies depending on the method of preparation and the plant materials used. This complexity and variability impact the reproducibility and interpretation of pharmacological, toxicological and clinical research.Objectives: This project develops best practice guidelines to ensure reproducibility and accurate interpretations of studies using medicinal plant extracts. The focus is on herbal extracts used in pharmacological, toxicological, and clinical/intervention research. Specifically, the consensus-based statement focuses on defining requirements for: 1) Describing the plant material/herbal substances, herbal extracts and herbal medicinal products used in these studies, and 2) Conducting and reporting the phytochemical analysis of the plant extracts used in these studies in a reproducible and transparent way.The process and methods: We developed the guidelines through the following process: 1) The distinction between the three main types of extracts (extract types A, B, and C), initially conceptualised by the lead author (MH), led the development of the project as such; 2) A survey among researchers of medicinal plants to gather global perspectives, opportunities, and overarching challenges faced in characterising medicinal plant extracts under different laboratory infrastructures. The survey responses were central to developing the guidelines and were reviewed by the core group; 3) A core group of 9 experts met monthly to develop the guidelines through a Delphi process; and. 4) The final draft guidelines, endorsed by the core group, were also distributed for feedback and approval to an extended advisory group of 20 experts, including many journal editors.Outcome: The primary outcome is the “Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts“ (ConPhyMP) which defines the best practice for reporting the starting plant materials and the chemical methods recommended for defining the chemical compositions of the plant extracts used in such studies. The checklist is intended to be an orientation for authors in medicinal plant research as well as peer reviewers and editors assessing such research for publication.

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Section: Resultsmentioning

confidence: 99%

Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12

Heinrich¹,

Jalil²,

Abdel‐Tawab

et al. 2022

Front. Pharmacol.

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“…For example, the number of carbon-13 signals helps to identify the structures of terpenes made up of isoprenoid units; the increase in area under the proton signal and the decrease in carbon-13 signals help to identify symmetric molecules; and specific proton and carbon-13 chemical shifts help to confirm the presence of aromatic rings or carbonyl groups in molecular structures. In addition, proton NMR spectra disclose the presence of certain functional groups, including hydroxyl and primary and secondary amine groups [ 42 , 43 ]. Therefore, NMR can be used to guide the isolation of natural products.…”

Section: Techniques For Separation and Chemical Characterization Of E...mentioning

confidence: 99%

Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review

et al. 2023

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The present review explores the growing interest in the techniques employed for extracting natural products. It emphasizes the limitations of conventional extraction methods and introduces superior non-conventional alternatives, particularly ultrasound-assisted extraction. Characterization and quantification of bioactive constituents through chromatography coupled with spectroscopy are recommended, while the importance of method development and validation for biomarker quantification is underscored. At present, electrospun fibers provide a versatile platform for incorporating bioactive extracts and have extensive potential in diverse fields due to their unique structural and functional characteristics. Thus, the review also highlights the fabrication of electrospun fibers containing bioactive extracts. The preparation of biologically active extracts under optimal conditions, including the selection of safe solvents and cost-effective equipment, holds promising potential in the pharmaceutical, food, and cosmetic industries. Integration of experimental design into extraction procedures and formulation development is essential for the efficient production of health products. The review explores potential applications of encapsulating natural product extracts in electrospun fibers, such as wound healing, antibacterial activity, and antioxidant properties, while acknowledging the need for further exploration and optimization in this field. The findings discussed in this review are anticipated to serve as a valuable resource for the processing industry, enabling the utilization of affordable and environmentally friendly, natural, and raw materials.

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“…Notably, qNMR offers advantages such as high precision, simple sample preparation, and time-saving capabilities. [19][20][21] The paper presents a 1 H-qNMR method for accurate determination of the total phenol content in cinnamon polyphenol extracts. The reliability of the qNMR method was validated through a comparative analysis with the conventional Folin-Ciocalteu spectrophotometric method.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, qNMR offers advantages such as high precision, simple sample preparation, and time-saving capabilities. 19–21…”

Section: Introductionmentioning

confidence: 99%

Determination of total phenol and six polyphenolic components in the polyphenol extract of Cinnamomi cortex by quantitative nuclear magnetic resonance spectroscopy

Shi,

Zheng,

Guo

et al. 2023

Anal. Methods

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NMR technique and methodology in botanical health product analysis and quality control

Cited by 20 publications

References 223 publications

Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12

Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12

Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review

Determination of total phenol and six polyphenolic components in the polyphenol extract of Cinnamomi cortex by quantitative nuclear magnetic resonance spectroscopy

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