NMR study of inclusion complexes formation between amphiphilic dimeric β-cyclodextrin derivative and some pharmacologically important compounds

Dimeric Diaminocationic β-Cyclodextrin Derivatives

“…[1][2][3][4] Earlier, we turned our attention to the dimeric cyclodextrins derivatives, in which two residues of the β-cyclodextrin ( Figure 1) are connected by a bridge. [5,6] In comparison with native CDs and monomodified CDs, dimeric CDs exhibit the significantly high binding abilities and molecular selectivity through the cooperative binding of two adjacent CD units. [7] This fascinating property enables them to be employed successfully in several areas of chemistry as an excellent model system mimicking substrate-specific interaction of enzymes.…”

“…[11] Thus, dimeric CDs could be successfully utilized in carriers, [12] catalysis, [8] templated synthesis, [13] photochemical materials, [14,15] solubilizers, [16] etc. The dimeric complex, in com-parison with the monomeric complex, has an enhanced synergistic effect on the inclusion of "guests" in its cyclodextrin cavity, [17][18][19] which could help for more efficient and targeting site delivery.…”

“…Di-6,6'-dideoxy-6,6'-(propane-1,3-diyldiaminium)-βcyclodextrin iodide (6). To a solution of 1.00 g (0.80 mmol) of mono(6-iodo-6-deoxy)-β-cyclodextrin 1 in 15 mL of DMF was added at stirring 0.030 g (0.40 mmol) of propane-1,3-diamino 2.…”

The effect of β-cyclodextrin on the Formation of Phospholipid Micelles: A Molecular Dynamics Simulation Study

“…The question naturally arises whether β-CD and its derivatives can be utilized to extract specific lipid types from the bio-member anes or micelles [28]. This suggestive idea has been the subject of several experimental studies, for example via NMR spectroscopy [29,30], fluorescence microscopy [31], neutron scattering [32], Brewster microscopy [33], calorimetry [34].…”