NMR spectroscopy to study cyclodextrin-based host–guest assemblies with polynuclear clusters

Abstract

Natural cyclodextrin (CD) macrocycles are known to form diverse inclusion complexes with a wide variety of organic molecules, but recent work has revealed that inorganic clusters also form multicomponent supramolecular...

Nanoencapsulation of Menthol/Cyclodextrin Inclusion Complexes in Rapidly Dissolving Electrospun Gelatin Nanofibers

“…In the realm of NMR spectroscopy, nuclear Overhauser effect spectroscopy (NOESY) and ROESY stand as prominent two-dimensional techniques extensively applied to scrutinize interactions involving CDs across a spectrum of guest molecules encompassing organic, inorganic, and hybrid compounds. Remarkably, ROESY, distinguished by its exceptional ability to probe interactions spanning distances of up to 5 Å, emerges as the preferred method over NOESY, particularly for investigating nanoscale assemblies constructed with CDs. , …”

“…Remarkably, ROESY, distinguished by its exceptional ability to probe interactions spanning distances of up to 5 Å, emerges as the preferred method over NOESY, particularly for investigating nanoscale assemblies constructed with CDs. 35,36 In this study, we strategically employed the ROESY NMR technique to discern the spatial nuances inherent in host− guest interactions within solutions containing α-CD/menthol, β-CD/menthol, and γ-CD/menthol (Figure 5). Analysis of the ROESY spectra for the β-CD/menthol and γ-CD/menthol systems revealed simultaneous proton resonances involving the inner cavity protons (H3 and H5) of the CDs and the protons of menthol.…”

Switchable Redox and Thermo‐Responsive Supramolecular Polymers Based on Cyclodextrin‐Polyoxometalate Tandem

“…Furthermore, NMR has been shown highly informative in studying qualitatively and quantitatively γCDs and related supramolecular behaviors [39,40] . As widely reported, these versatile macrocycles provide local NMR probes sensitive to through‐space interactions with guest molecules.…”

Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films

“…The ROESY technique enables probing interactions over extended distances up to 5 Å, so it is distinguished for the investigation of nanoscale assemblies constructed with CD. 48 Therefore, 2D-NMR (ROESY) measurement was also performed to examine the spatial interactions within the inclusion complexes of naproxen and HPβCD. Fig.…”