NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes

Abstract

Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users.[a] Prof.

Insights into the Effects of Crack Abuse on the Human Metabolome Using a NMR Approach

“…Recently, we have demonstrated that by using 1 H NMR-based metabolomics it was possible to separate healthy control (HC) individuals from schizophrenia or from bipolar patients . Also, we have demonstrated that it is possible to employ the same technique to discriminate crack users and schizophrenia patients who may share similar symptoms . In the present research, we performed 1 H NMR-based metabonomic analysis of crack users’ serum samples aiming to understand the metabolic changes related to the drug disorder and identify biomarkers that might be correlated with brain dysfunction.…”

Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia

“…Desirable biomarker candidates should have features including their correlation with functional outcomes and practical, inexpensive, reproductive, and non-invasive methods of their determination and monitoring [13,14]. Currently, proteomics, genomics, and metabolomics are important platforms for measuring potential biomarkers in psychiatric diseases [15][16][17][18][19][20][21][22][23].…”