NMR spectroscopy: a powerful tool for the analysis of polyphenols in extra virgin olive oil

Olmo‐Cunillera, Alexandra; López‐Yerena, Anallely; Lozano‐Castellón, Julián; Tresserra‐Rimbau, Anna; Vallverdú‐Queralt, Anna; Pérez, Maria

doi:10.1002/jsfa.10173

Cited by 23 publications

(18 citation statements)

References 53 publications

(148 reference statements)

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“…This requirement reinforces the need to correlate the characterization of the phenolic compounds to their biological activity; this is especially true for human studies, even if this correlation is often missing in these cases. In fact, although the chemical characterization of VOO’s phenolic compounds was extensively studied with consolidated techniques [ 12 , 13 ], its correlation with the biological effects, mainly linked to the antioxidant and/or the anti-inflammatory properties, is only partially investigated.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Chemical Characterization and Biological Activity: An Urgent Need for Human Studies Using Extra Virgin Olive Oil

2022

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Extra virgin olive oil (EVOO) is one of the most important functional foods from the Mediterranean Diet due to its beneficial effect on human health in terms of prevention and/or adjuvant treatment of different pathological conditions. The positive effects linked to EVOO consumption are not only due to its major (monounsaturated fatty acids), but also to its minor components (phenolics), whose roles were greatly re-evaluated in the last years. Notwithstanding the huge number of studies demonstrating the antioxidant, anti-inflammatory and anti-cancer properties of EVOO’s phenolic compounds, only their antioxidant ability was supported by a Health Claim. However, to bear the claim, a specific phenolic composition is needed, thus reinforcing the need to correlate the characterization of the phenolic compounds to their biological activity. In fact, although the chemical characterization of VOO’s phenolic compounds was extensively studied, its correlation with biological effects is only partially investigated; this is especially true for human studies. This review aims to study the correlation between the chemical characterization of EVOO’s phenolics and the biological effects in terms of antioxidant/anti-inflammatory potentials, with a focus on the human studies and the relative concern on getting a specific Health Claim.

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Section: Introductionmentioning

confidence: 99%

Correlation between Chemical Characterization and Biological Activity: An Urgent Need for Human Studies Using Extra Virgin Olive Oil

2022

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“…Most techniques for EVOO phenolic analysis are based on liquid–liquid extraction and various determination methods, the most common being liquid chromatography coupled to different detectors, such as a diode array detector (International Olive Council, 2017b), MS (Alessandri et al., 2014), or MS in tandem (Lozano‐Castellón et al., 2021). Other methods are nuclear magnetic resonance (Olmo‐Cunillera et al., 2020) or GC‐MS (Chiou et al., 2007), which need an extra step for volatilizing the target compounds.…”

Section: Fraud Authentication and Traceability Of Evoomentioning

confidence: 99%

Extra virgin olive oil: A comprehensive review of efforts to ensure its authenticity, traceability, and safety

Lozano‐Castellón

López‐Yerena

Domínguez-López

et al. 2022

Comp Rev Food Sci Food Safe

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The growing demand for extra virgin olive oil (EVOO), appreciated for its unique organoleptic properties and health benefits, has led to various fraudulent practices to maximize profits, including dilution with lower value edible oils. The adulterated oils would be of poor nutritional quality, more readily oxidized, and may contain unhealthy substances formed during processing. Nevertheless, the range of available techniques to detect fraud in EVOO production has been growing. Reliable markers of EVOO adulteration include fatty acids and minor components such as sterols, tocopherols, triterpene alcohols, phenolic compounds, phospholipids, volatile compounds, and pigments. Additionally, increasing consumer interest in high-quality EVOO has led to the development of robust scientific methods for its traceability. This review focuses on (i) the usefulness of certain compounds as markers of EVOO adulteration; (ii) the potential health risks of consuming adulterated EVOO; and (iii) reliable methods for the geographical traceability of olive oil. In conclusion, fraudulent production practices need to be detected to preserve the beneficial health effects of EVOO and to avoid the potential risks associated with ingesting substandard oil. In this work, as EVOO certification and regulatory framework limitations have already been extensively reviewed, we focus our attention on biomarkers that guarantee both the authenticity and traceability of oil, and consequently its health properties. When it is unavailable to obtainThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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“…NMR spectroscopy is a potent tool for the qualitative and quantitative analysis of complex mixtures of small molecules and has been used to analyze PC in food [129][130][131]. NMR-based metabolomics offers a powerful approach to metabolite fingerprinting and profiling [132].…”

Section: Nmrmentioning

confidence: 99%

Metabolomics Technologies for the Identification and Quantification of Dietary Phenolic Compound Metabolites: An Overview

et al. 2021

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In the search for natural products with properties that may protect against or slow down chronic and degenerative diseases (e.g., cancer, and cardiovascular and neurodegenerative conditions), phenolic compounds (PC) with benefits for human health have been identified. The biological effects of PC in vivo depend on their bioavailability, intestinal absorption, metabolism, and interaction with target tissues. The identification of phenolic compounds metabolites (PCM), in biological samples, after food ingestion rich in PC is a first step to understand the overall effect on human health. However, their wide range of physicochemical properties, levels of abundance, and lack of reference standards, renders its identification and quantification a challenging task for existing analytical platforms. The most frequent approaches to metabolomics analysis combine mass spectrometry and NMR, parallel technologies that provide an overview of the metabolome and high-power compound elucidation. In this scenario, the aim of this review is to summarize the pre-analytical separation processes for plasma and urine samples and the technologies applied in quantitative and qualitative analysis of PCM. Additionally, a comparison of targeted and non-targeted approaches is presented, not available in previous reviews, which may be useful for future metabolomics studies of PCM.

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NMR spectroscopy: a powerful tool for the analysis of polyphenols in extra virgin olive oil

Cited by 23 publications

References 53 publications

Correlation between Chemical Characterization and Biological Activity: An Urgent Need for Human Studies Using Extra Virgin Olive Oil

Correlation between Chemical Characterization and Biological Activity: An Urgent Need for Human Studies Using Extra Virgin Olive Oil

Extra virgin olive oil: A comprehensive review of efforts to ensure its authenticity, traceability, and safety

Metabolomics Technologies for the Identification and Quantification of Dietary Phenolic Compound Metabolites: An Overview

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