NMR spectroscopic study of the inclusion complex of desloratadine with β-cyclodextrin in solution

Ali, Sk Ajim; Upadhyay, Swati; Maheshwari, Arti

doi:10.1007/s10847-007-9335-y

Cited by 18 publications

(9 citation statements)

References 10 publications

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“…[10,11] The present work is devoted to the preparation and characterization of the complexes formed by the interaction of β-cyclodextrin (β-CD) and MDL in aqueous solution. 1 H NMR spectral analysis has been used to study shift changes, a COSY spectrum for assignment of protons and a ROESY spectrum for elucidation of the structure of the β-CD-MDL complex.…”

Section: Introductionmentioning

confidence: 99%

Complexation study of midazolam hydrochloride with β‐cyclodextrin: NMR spectroscopic study in solution

Ali

Upadhyay

2008

Magnetic Reson in Chemistry

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(1)H NMR spectroscopic study of midazolam hydrochloride (MDL), beta-cyclodextrin (beta-CD) and their mixtures confirmed the formation of beta-CD-MDL inclusion complex in aqueous solution. The stoichiometry of the complexes was determined by Scott's method to be 1:1, and the association constant (K(a)) was calculated to be 108 M(-1). It was confirmed on the basis of 2D ROESY spectral data that only a fluorine-substituted aromatic ring acted as guest in complexation. Most of the aromatic signals of MDL exhibited induced shift changes as well as splitting, in the presence of beta-CD, indicating chiral differentiation of MDL by beta-CD.

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Section: Introductionmentioning

confidence: 99%

Complexation study of midazolam hydrochloride with β‐cyclodextrin: NMR spectroscopic study in solution

Ali

Upadhyay

2008

Magnetic Reson in Chemistry

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“…The combination of both analytical methods proved very suitable to obtain information about the structure of the DL loaded polymers. 31,32 A simple and validated HPLC method was adopted and developed for the determination of DL. The method was validated for accuracy, precision and linearity with reference to the International Council for Harmonisation guidelines.…”

Section: Resultsmentioning

confidence: 99%

Desloratadine-Eudragit<sup>®</sup> RS100 Nanoparticles: Formulation and Characterization

Yenilmez

2017

tjps

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ÖZAmaç: Bu çalışmanın amacı, Desloratadin-Eudragit ® RS100 nanopartiküllerini formüle etmek ve hazırlanan nanopartiküllerin özelliklerini araştırmaktır. Gereç ve Yöntemler: Nanopartiküller püskürterek kurutma yöntemi ile hazırlanmış ve miktar tayini yüksek basınçlı sıvı kromatografisi (YBSK) yöntemi ile yapılmıştır. Bulgular: Desloratadin (DL) başarıyla polimere yüklenmiş ve geliştirilen YBSK yönteminin doğrusal, tekrarlanabilir, hassas, doğru, spesifik ve selektif olduğu bulunmuştur. Önerilen püskürterek kurutma yöntemi, DL içeren nanopartikül preparatının hazırlanmasında başarı ile kullanılmıştır. Nanopartiküllerin karakterizasyonu partikül boyutu, zeta potansiyel, morfoloji, polidispersite indeksi, katı hal karakterizasyonları ve etkin madde salımı dahil olmak üzere yapılmıştır. DL yüklü nanopartiküllerin in vitro salım çalışmaları, simüle edilmiş barsak vasatında (pH 7.4) incelenmiştir. Nanopartikül formülasyonlarından DL'nin in vitro salımı, Korsemeyer-Peppas modeline uymaktadır. Sonuç: DL miktar tayini için YBSK yöntemi geliştirilmiştir. Önerilen püskürterek kurutma yöntemi, DL içeren nanopartikül preparatına başarıyla uygulanmıştır. Ayrıca, tüm nanopartiküllerin ve etkin maddenin salım çalışmaları karşılaştırmalı olarak incelenmiştir. Bu nedenle, DL yüklü nanopartiküllerin etkin madde için umut verici bir ilaç taşıyıcı sistem olduğu sonucuna varılabilir. Anahtar kelimeler: Desloratadin, Eudragit ® RS100, YBSK, nanopartikül Objectives:The objective of the present study was to formulate Desloratadine-Eudragit ® RS100 nanoparticles and investigate the characteristics of the prepared nanoparticles. Materials and Methods: The nanoparticles were prepared by spray drying method and the quantification of desloratadine (DL) was carried out with a high performance liquid chromatography (HPLC) method. Results: DL was successfully loaded to polymer and the developed HPLC method was found to be linear, reproducible, precise, accurate, specific and selective. Characterization of the nanoparticles including entrapment efficiency, particle size, zeta potential, morphology, polidispersity index, solid state characterizations and drug release was performed. In vitro release studies of DL loaded nanoparticles were also examined in the simulated intestinal fluid (pH 7.4). In vitro release of DL from nanoparticle formulations followed Korsemeyer-Peppas model. Conclusion: A validated HPLC method was developed for the determination of DL. Proposed spray drying method can be successfully applicable to the nanoparticle preparation containing DL. In addition, the release studies of all nanoparticles and active substance have been studied comparatively. Hence, it could be concluded that DL loaded nanoparticles seem to be a promising drug delivery system for the active agent.

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“…Various techniques can be applied for enhancement of the solubility and dissolution rate of poorly water soluble drugs such as solubilization by cosolvents (11), salt formation (12), inclusion complex in cyclodextrins (13), solid dispersions (14)(15)(16), and micellization (17,18). For chrysin, enhancement of its water solubility by cosolvents has been reported (19).…”

Section: Introductionmentioning

confidence: 99%

Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos

Sassa-deepaeng

Pikulkaew

Okonogi

2016

DD&T

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NMR spectroscopic study of the inclusion complex of desloratadine with β-cyclodextrin in solution

Cited by 18 publications

References 10 publications

Complexation study of midazolam hydrochloride with β‐cyclodextrin: NMR spectroscopic study in solution

Complexation study of midazolam hydrochloride with β‐cyclodextrin: NMR spectroscopic study in solution

Desloratadine-Eudragit<sup>®</sup> RS100 Nanoparticles: Formulation and Characterization

Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos

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