“…Previous studies explained the fact that the dissociation rate of Ce(DOTA) 0 is much slower than that of Ce(TETA) 0 (1,4,8,11-tetraazacyclotetra-decane-N,N,NЉ,Nٞ-tetraacetic acid) (27). Despite the same cavity size (15-cycle), the acid-catalyzed rate of Ce (4) / dissociates about one order of magnitude faster than that of Ce(DTPA)-EAM (1,4,7-tris(carboxymethyl)-9,14-dioxo-1,4,7,10,13-pentaazacyclopentadecane) (15). This may be attributed to the decrease of one nitrogen donor and one carboxylic acid pendent arm compared to DTPA-EAM.…”