NMR-Based Plant Metabolomics in Nutraceutical Research: An Overview

Abstract

Few topics are able to channel the interest of researchers, the public, and industries, like nutraceuticals. The ever-increasing demand of new compounds or new sources of known active compounds, along with the need of a better knowledge about their effectiveness, mode of action, safety, etc., led to a significant effort towards the development of analytical approaches able to answer the many questions related to this topic. Therefore, the application of cutting edges approaches to this area has been observed. Among these approaches, metabolomics is a key player. Herewith, the applications of NMR-based metabolomics to nutraceutical research are discussed: after a brief overview of the analytical workflow, the use of NMR-based metabolomics to the search for new compounds or new sources of known nutraceuticals are reviewed. Then, possible applications for quality control and nutraceutical optimization are suggested. Finally, the use of NMR-based metabolomics to study the impact of nutraceuticals on human metabolism is discussed.

Proteomics and Metabolomics Studies on the Biotic Stress Responses of Rice: an Update

“…NMR spectroscopy is considered to be less biased due to its independence of ionization. In addition, this method is highly reproducible, requires minimum sample preparation, and can identify novel compounds (Valentino et al 2020 ). NMR is rarely used to study rice metabolomics in response to biotic stress (Table 2 ).…”

Differentiating Pu‐erh raw tea from different geographical origins by1H‐NMR and U‐HPLC/Q‐TOF‐MS combined with chemometrics

“…In comparison with chromatographic methods, NMR is an excellent choice to overcome the deficiencies mentioned above. NMR is performed to metabolomics technology thanks to its advantages of nondestructiveness, reproducibility, nontargeting, unbiasedness, simple sample preparation, and simultaneous detection of diverse groups of secondary and primary metabolites (Valentino et al., 2020).…”

“…Recently, Pu‐erh ripe tea has been become the main research object of tea (Chen et al., 2016; Roda et al., 2019; Valentino et al., 2020; Zhang et al., 2019b). As to Pu‐erh raw tea, the researchers are rarely and mainly focus on its pharmacological activities or performances.…”

Plant Metabolomics: An Overview

“…Researchers believe that more than 400,000 plant species exist worldwide [2]. Total number of metabolites in the plant kingdom are about 2,00,000 to 10,00,000.…”