NMDAR antibody encephalitis overlapping with CLIPPERS syndrome in a psoriasis patient on adalimumab

Martin, Talora; Duke, Sean; Kumar, Veena R.; Fadhil, Ali; Ibrahim, Rami Mossad; Palmer, Kaitlin; Yazdani, Saad; Devereaux, Michael W.; Gunzler, Steven A.; Serra, Alessandro; Abboud, Hesham

doi:10.1007/s00415-020-10341-4

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…7 Table 1 summarizes this case, as well as 5 additional case reports of autoimmune encephalitis in patients on anti-TNF therapies published to date. [7][8][9][10][11] Most cases identified have occurred with patients on adalimumab, with NMDAr-AE occurring within 9 months of anti-TNF therapy. The case reported by Oh et al deviated from this trend with a patient who had been on infliximab for 9 years before developing NMDAr-AE.…”

Section: Discussionmentioning

confidence: 99%

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Anti-N‐Methyl‐D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease

MacKay,

Salh

2024

ACG Case Rep J

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A 46-year-old woman with fistulizing Crohn's disease in clinical remission in the setting of long-term adalimumab therapy presented to hospital and was ultimately diagnosed with anti‐N‐methyl‐D (NMDA) receptor antibody-mediated autoimmune encephalitis (NMDAr-AE). Inflammatory central nervous system and antibody-mediated adverse effects have been found to be associated with anti–tumor necrosis factor agents, with 5 previous case reports noting cases of NMDAr-AE in patients on these medications. The current article reports this case, which is unique for the length of adalimumab therapy before this presentation, as well as a summary of literature regarding anti–tumor necrosis factors and NMDAr-AE.

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Section: Discussionmentioning

confidence: 99%

“…6 In recent years, 5 case reports have been published describing cases of NMDAr-AE in patients being treated with anti-TNF therapies. [7][8][9][10][11] The current article reports a case of NMDAr-AE in a patient with CD on long-term adalimumab therapy.…”

Section: Introductionmentioning

confidence: 99%

Anti-N‐Methyl‐D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease

MacKay,

Salh

2024

ACG Case Rep J

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“…Screening MOGAD as a CLIPPERS mimicker is crucial to avoid misdiagnosis ( 8 ). Martin et al had reported a case of anti-NMDAR encephalitis overlapping with CLIPPERS syndrome ( 9 ). However, imaging findings of CLIPPERS in MNOS have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Case Report: A Case With MOGAD and Anti-NMDAR Encephalitis Overlapping Syndrome Mimicing Radiological Characteristics of CLIPPERS

Guo

Liu

2022

Front. Immunol.

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Herein, we reported a case of a young man diagnosed with MNOS (anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD) and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis overlapping syndrome, i.e., MNOS), whose imaging findings in magnetic resonance imaging (MRI) mimicked chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). We reported a case of refractory anti-NMDAR encephalitis that recurred after standard first-line and second-line treatment. The patient presented with CLIPPERS on imaging at recent hospital admission, and his MOG antibodies were seropositive. After intravenous methylprednisolone (IVMP) treatment, the patient’s symptoms were significantly alleviated. In this case, we demonstrated that MNOS could mimic the radiological characteristics of CLIPPERS. Future studies should focus on the diagnosis and treatment of antibody overlap syndrome.

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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): contemporary advances and current controversies

Li,

Lai,

Cai

et al. 2024

J Neurol

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NMDAR antibody encephalitis overlapping with CLIPPERS syndrome in a psoriasis patient on adalimumab

Cited by 6 publications

References 7 publications

Anti-N‐Methyl‐D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease

Anti-N‐Methyl‐D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease

Case Report: A Case With MOGAD and Anti-NMDAR Encephalitis Overlapping Syndrome Mimicing Radiological Characteristics of CLIPPERS

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): contemporary advances and current controversies

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