“NMDA receptor spectrum disorder” in the differential diagnosis of demyelinating disorders of the CNS: optic neuritis and myelitis

Etemadifar, Masoud; Abhari, Amir Parsa; Sabeti, Fatemeh; Ganjalikhani‐Hakemi, Mazdak; Salari, Mehri; Hashemi, Fatemeh; Aghababaee, Ali; Khorvash, Reza; Khayati, Mohammad Hasan; Nouri, Hosein

doi:10.1007/s10072-020-04518-y

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…14 Finally, seizures are a well-described phenomenon occurring in association with MOGAD, estimated to occur in approximately 20% of patients with MOGAD, 15 compared with approximately 3% of patients with MS 16,17 and less than 1% of patients with NMOSD. 6 Seizures in MOGAD have also been reported to cluster around other demyelinating events, such as ON, 18 as seen in our patient.…”

Section: Discussionsupporting

confidence: 76%

“…This patient's presentation of aseptic meningoencephalitis, elevated CRP and ESR, and relatively low MOG-Ab titer 5 prompted further investigation of possible systemic diseases, such as sarcoidosis, granulomatosis with angiitis, and autoimmune encephalitis. 6 Granulomatosis with angiitis was considered unlikely with negative anti-neutrophil cytoplasm antibodies (eTable 1, links.lww.com/NXI/A781 ) and lack of other organ involvement. Full body PET with CT scan did not reveal findings typical of sarcoid, and her CSF profile with normal protein and glucose would also be atypical for neurosarcoidosis.…”

Section: Differential Diagnosismentioning

confidence: 99%

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MOG Antibody–Associated Disease and Thymic Hyperplasia

Hurtubise

Frohman

Galetta

et al. 2023

Neurol Neuroimmunol Neuroinflamm

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Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.

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Section: Discussionsupporting

confidence: 76%

Section: Differential Diagnosismentioning

confidence: 99%

MOG Antibody–Associated Disease and Thymic Hyperplasia

Hurtubise

Frohman

Galetta

et al. 2023

Neurol Neuroimmunol Neuroinflamm

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Non-infectious meningitis and CNS demyelinating diseases: A conceptual review

et al. 2023

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N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective

Abhari

Etemadifar

Yazdanpanah

et al. 2022

MRMC

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N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors, highly important in regulating substantial physiologic processes in the brain and the nervous system, and disturbance in their function could contribute to different pathologies. Overstimulation and hyperactivity of NMDARs, termed as glutamate toxicity, could promote cell death and apoptosis. Meanwhile, their blockade could lead to dysfunction of the brain and nervous system as well. A growing body of evidence has demonstrated the prominent role of NMDARs in demyelinating disorders and anti-NMDAR encephalitis. Herein, we provide an overview of the role of NMDARs’ dysfunction in the physiopathology of demyelinating disorders such as multiple sclerosis and neuromyelitis optica spectrum disorders.

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“NMDA receptor spectrum disorder” in the differential diagnosis of demyelinating disorders of the CNS: optic neuritis and myelitis

Cited by 4 publications

References 30 publications

MOG Antibody–Associated Disease and Thymic Hyperplasia

MOG Antibody–Associated Disease and Thymic Hyperplasia

Non-infectious meningitis and CNS demyelinating diseases: A conceptual review

N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective

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