2007
DOI: 10.1523/jneurosci.2422-07.2007
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NMDA Receptor Contribution to the Climbing Fiber Response in the Adult Mouse Purkinje Cell

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Cited by 107 publications
(114 citation statements)
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References 69 publications
(108 reference statements)
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“…Although recent studies have shown that PCs of adult mice express functional NMDARs at synapses with climbing fibers (31,32), functional NMDARs are not present after postnatal day 7 in PCs of juvenile rats (33,34) (Fig. S2).…”
Section: Resultsmentioning
confidence: 92%
“…Although recent studies have shown that PCs of adult mice express functional NMDARs at synapses with climbing fibers (31,32), functional NMDARs are not present after postnatal day 7 in PCs of juvenile rats (33,34) (Fig. S2).…”
Section: Resultsmentioning
confidence: 92%
“…1) leads to the question of whether CF activity indeed promotes LTD by amplifying calcium transients, or whether it contributes other signaling factors that trigger the switch toward LTD. For example, CF activity results in the release of corticotropin-releasing factor, which promotes LTD at PF and CF synapses by activation of PKC (33,34). In addition, in the mature cerebellum, CF stimulation recruits a specific calcium source that is not available at PF synapses, postsynaptically located NMDA receptors (7,35,36). It is conceivable that these CF-specific signaling components contribute to LTD.…”
Section: Discussionmentioning
confidence: 99%
“…7 and 8a). Given that Purkinje cells are thought to express relatively low amounts of functional NMDA receptors [4,21] and that only CF but not PF stimulation could induce an NMDA receptor current in PNs of adult rodents [32,34], while molecular layer interneurons are known for a rich expression of NMDA receptors [1,9], we propose that interneurons are the most likely source of NO for preLTP [33,39] and of endocannabinoids [6] for pre LTD. Of course, we cannot exclude that 4 Hz PF stimulation also activates NMDA and/or mGlu1 receptors on PNs to some degree resulting in some release of endocannabinoids. If the LTD observed in PNs that were patch-clamped with a high concentration of a Ca 2+ chelator (30 mM BAPTA) in the intracellular solution (Figs.…”
Section: Demonstration Of Preltdmentioning
confidence: 91%