2022
DOI: 10.3390/jpm12122063
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NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection

Abstract: (1) Background: With the resurgence of brucellosis epidemics in China in recent years, the chances of a brucella coinfection with other common respiratory pathogens, such as the influenza virus, have increased dramatically. However, little is known about the pathogenicity or the mechanisms of brucella and influenza coinfections. (2) Methods: To clarify the interventions in the early stages of lung damage due to brucella and influenza coinfections, we evaluated the effect of the coinfection on disease progressi… Show more

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“…During lung infections, NLRP6 exhibits diverse effects depending on the microbe (Ghimire et al, 2018;Xu et al, 2021;Shi et al, 2022). NLRP6 plays a damaging role in the intestinal phase of Brucella infection (Rungue et al, 2021).…”
Section: Nod-like Receptors (Nlrs)mentioning
confidence: 99%
“…During lung infections, NLRP6 exhibits diverse effects depending on the microbe (Ghimire et al, 2018;Xu et al, 2021;Shi et al, 2022). NLRP6 plays a damaging role in the intestinal phase of Brucella infection (Rungue et al, 2021).…”
Section: Nod-like Receptors (Nlrs)mentioning
confidence: 99%