NLRP3 Is Expressed in Human Dental Pulp Cells and Tissues

NLRP3 inflammasome may regulate inflammatory response of human periodontal ligament fibroblasts in an apoptosis‐associated speck‐like protein containing a CARD (ASC)‐dependent manner

“…, Song et al . ). It has been reported that NLRP3 was expressed in human dental pulp tissue and human dental pulp fibroblasts and played a biological role in irreversible pulpitis (Jiang et al .…”

“…The NLRP3 inflammasome is by far the most studied inflammasome. NLRP3 is not only expressed in immune cells, such as neutrophils, monocytes, dendritic cells and B and T lymphocytes but also in some nonimmune cells, including epithelial cells and osteoblasts (Masumoto et al 2001, Kummer et al 2007, Song et al 2012. It has been reported that NLRP3 was expressed in human dental pulp tissue and human dental pulp fibroblasts and played a biological role in irreversible pulpitis (Jiang et al 2015).…”

Immunohistochemical localization of NALP3 inflammasome in experimental periapical lesions

“…) and pulpal fibroblasts (Song et al . ) all expressed NALP3. The present findings are supplement and reinforce these previous reports.…”

“…, Song et al . ). Results from animal models of periapical lesions suggest that IL‐1β plays a significant part in periapical inflammation and lesion expansion (Kawashima et al .…”

Absent in Melanoma 2 (AIM2) in Rat Dental Pulp Mediates the Inflammatory Response during Pulpitis

“…AIM2 is expressed in the dental pulp and cells, indicating that AIM2 may play an important role in the immune response of the pulp dentin complex. In addition, Song et al (21) reported that the NLRP3 inflammasome is expressed in human dental pulp cells and tissues. These results are similar to those of our studies, suggesting that the inflammasome may play an important role in dental pulpitis.…”