NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Wang, Zhilei; Xu, Guang; Li, Zhiyong; Xiao, Xiaohe; Tang, Jian-Yuan; Bai, Zhaofang

doi:10.2147/jir.s344071

Cited by 13 publications

(3 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoids are considered to be the main biologically active components of licorice. Studies revealed that flavonoids exert different pharmacological functions, such as antiplatelet, antiinflammatory, anticancer, antioxidative, antimicrobial, immunomodulatory, and cardioprotective effects (14)(15)(16).…”

Section: Original Articlementioning

confidence: 99%

The inhibitory effect of isoliquiritigenin on human platelets in vitro

Wu¹,

Cheng²,

Wang³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

Background: Platelets play important roles in several physiological and pathological processes. Multiple antiplatelet drugs have been developed for clinical practice. The active components of traditional Chinese medicine with antithrombotic effects are promising drugs to modulate platelet function. In our study, the antiplatelet effect of isoliquiritigenin (ILTG) and its mechanisms were examined.Methods: Human platelet-rich plasma and a washed platelet suspension were prepared. Platelets were stimulated using collagen, thrombin, or adenosine diphosphate (ADP). The platelet lumi-aggregometer was applied to detect the aggregation of platelets and the release of adenosine triphosphate (ATP). The expression of P-selectin and the activation of integrin αIIbβ3 were detected using flow cytometry. The spreading of platelets on a fibrinogen-coated surface was visualized using immunofluorescent staining. The mechanisms of the antiplatelet effect were investigated using Western blotting.Results: In this study, ILTG inhibited collagen-and thrombin-induced platelet aggregation, the release of dense granules and α-granules, and the activation of integrin αIIbβ3 in a dose-dependent manner. In addition, ILTG suppressed the spreading of platelets on immobilized fibrinogen. In collagen-activated platelets, ILTG markedly inhibited the expression of phosphorylation of phospholipase C gamma-2 (PLCγ2) and protein kinase B (Akt).Conclusions: These results indicated that ILTG could inhibit the collagen-and thrombin-induced platelet aggregation and granule release via the glycoprotein VI-mediated signal pathway in vitro.

show abstract

Section: Original Articlementioning

confidence: 99%

The inhibitory effect of isoliquiritigenin on human platelets in vitro

Wu¹,

Cheng²,

Wang³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Except for MCC950, multiple drugs, such as 3,4-methylenedioxy-bnitrostyrene, bioactive derivatives (eg, echinatin, etc.) from medicinal plants, have been found to interfere directly with the NLRP3 (91,103). NLRP3-targeted therapies provide potential and prospects for the treatment of related diseases including severe asthma.…”

Section: Pyroptosis and Inflammationrelated Respiratory Diseases 21 S...mentioning

confidence: 99%

Pyroptosis and respiratory diseases: A review of current knowledge

Sun

2022

Front. Immunol.

View full text Add to dashboard Cite

Pyroptosis is a relatively newly discovered programmed cell death accompanied by an inflammatory response. In the classical view, pyroptosis is mediated by caspases-1,-4,-5,-11 and executed by GSDMD, however, recently it was demonstrated that caspase-3 and-8 also participate in the process of pyroptosis, by cleaving GSDMD/E and GSDMD respectively. Different from autophagy and apoptosis, many pores are formed on the cell membrane during pyroptosis, which makes the cell membrane lose its integrity, eventually leading to the release of cytokines interleukin(IL)-1β and IL-18. When the body is infected with pathogens or exposed to some stimulations, pyroptosis could play an immune defense role. It is found that pyroptosis exists widely in infectious and inflammatory respiratory diseases such as acute lung injury, bronchial dysplasia, chronic obstructive pulmonary disease, and asthma. Excessive pyroptosis may accompany airway inflammation, tissue injury, and airway damage, and induce an inflammatory reaction, leading to more serious damage and poor prognosis of respiratory diseases. This review summarizes the relationship between pyroptosis and related respiratory diseases.

show abstract

“…Emerging immunological studies also show that NLRP3 inflammasomes play an important role in the development of FLD and might be a promising therapeutic target for the treatment of FLD. Moreover, a variety of Chinese herbal formulations, TCM extracts, and natural products exert a wide range of anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and showing a potent and effective effect in various FLD ( Fan et al, 2020 ; Wang et al, 2022 ). In this review, we systematically summarized the role and mechanisms of NLRP3 inflammasome activation in FLD and how the TCM targets and regulates NLRP3 inflammasome to improve the development of FLD.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological effects of Chinese medicine modulating NLRP3 inflammasomes in fatty liver treatment

Liu

Xu²,

Liang³

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Inflammation is a key contributing factor in the pathogenesis of fatty liver diseases (FLD), such as nonalcoholic fatty liver disease (NAFLD) and alcohol-associated liver diseases (ALDs). The NLRP3 inflammasome is widely present in the hepatic parenchymal and non-parenchymal cells, which are assembled and activated by sensing intracellular and extracellular danger signals resulting in the matures of IL-1β/IL-18 and pyroptosis. Moreover, the aberrant activation of the NLRP3 inflammasome is considered the main factor to drives immune outbreaks in relation to hepatic injury, inflammation, steatosis, and fibrosis. Therefore, inhibition of NLRP3 inflammasome may be a promising therapeutic target for FLD. Currently, accumulating evidence has revealed that a number of traditional Chinese medicines (TCM) exert beneficial effects on liver injury via inhibiting the NLRP3 inflammasome activation. Here, we summarized the mechanism of NLRP3 inflammasomes in the progression of FLD, and TCM exerts beneficial effects on FLD via positive modulation of inflammation. We describe that TCM is a promising valuable resource for the prevention and treatment agents against FLD and has the potential to be developed into clinical drugs.

show abstract

NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Cited by 13 publications

References 116 publications

The inhibitory effect of isoliquiritigenin on human platelets in vitro

The inhibitory effect of isoliquiritigenin on human platelets in vitro

Pyroptosis and respiratory diseases: A review of current knowledge

Pharmacological effects of Chinese medicine modulating NLRP3 inflammasomes in fatty liver treatment

Contact Info

Product

Resources

About