NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases

Prakash, Annamneedi Venkata; Park, Il Ho; Park, Jun Woo; Bae, Jong‐Sup; Lee, Geum Seon; Kang, Tae Jin

doi:10.4062/biomolther.2023.099

Cited by 8 publications

(1 citation statement)

References 67 publications

(92 reference statements)

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“…CRP increased the expression of pro-IL-1β and NLRP3 through the FcγRs/NF-κB pathway in endothelial cells. It also promoted NLRP3 inflammasome activation and IL-1β maturation by upregulating ROS levels, purinergic receptor signaling, and the activation of cysteine proteases ( Bian et al ., 2019 ; Prakash et al ., 2023 ). These findings indicate an association between elevated levels of CRP and NLRP3 inflammasomes in atherosclerosis.…”

Section: Atherosclerosismentioning

confidence: 99%

C-Reactive Protein Signaling Pathways in Tumor Progression

Kim

Moon

2023

Biomol Ther (Seoul)

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Many cancers arise from sites of chronic inflammation, which creates an inflammatory microenvironment surrounding the tumor. Inflammatory substances secreted by cells in the inflammatory environment can induce the proliferation and survival of cancer cells, thereby promoting cancer metastasis and angiogenesis. Therefore, it is important to identify the role of inflammatory factors in cancer progression. This review summarizes the signaling pathways and roles of C-reactive protein (CRP) in various cancer types, including breast, liver, renal, and pancreatic cancer, and the tumor microenvironment. Mounting evidence suggests the role of CRP in breast cancer, particularly in triple-negative breast cancer (TNBC), which is typically associated with a worse prognosis. Increased CRP in the inflammatory environment contributes to enhanced invasiveness and tumor formation in TNBC cells. CRP promotes endothelial cell formation and angiogenesis and contributes to the initiation and progression of atherosclerosis. In pancreatic and kidney cancers, CRP contributes to tumor progression. In liver cancer, CRP regulates inflammatory responses and lipid metabolism. CRP modulates the activity of various signaling molecules in macrophages and monocytes present in the tumor microenvironment, contributing to tumor development, the immune response, and inflammation. In the present review, we overviewed the role of CRP signaling pathways and the association between inflammation and cancer in various types of cancer. Identifying the interactions between CRP signaling pathways and other inflammatory mediators in cancer progression is crucial for understanding the complex relationship between inflammation and cancer.

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Section: Atherosclerosismentioning

confidence: 99%