NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

Peng, Hong; Gu, Ruonan; Li, Fengxian; Xiong, Xiaoxing; Liang, Wenbin; Zhang, You; Zhang, Hongfei

doi:10.1186/s12974-019-1498-0

Cited by 112 publications

(69 citation statements)

References 136 publications

(143 reference statements)

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“…The best-known inflammasome is NLRP3 made of NLRP3 protein, ASC adaptor protein (apoptosis-associated speck-like protein containing a carboxy-terminal CARD) and procaspase-1. [29][30][31] Activation of the NLRP3 inflammasome takes place in two stages: stage one (starting state)preparation (signal 1) and stage twoactivation stage (signal 2).…”

Section: The Role Of Nlrp3 Inflammasomementioning

confidence: 99%

<p>The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke</p>

Pawluk¹,

Woźniak²,

Grześk³

et al. 2020

CIA

116

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Stroke is currently one of the most common causes of death and disability in the world, and its pathophysiology is a complex process, involving the oxidative stress and inflammatory reaction. Unfortunately, no biochemical factors useful in the diagnostics and treatment of stroke have been clearly established to date. Therefore, researchers are increasingly interested in the inflammatory response triggered by cerebral ischemia and its role in the development of cerebral infarction. This article gives an overview of the available literature data concerning the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral circulation disturbances can also suggest certain immune response regulatory mechanisms aimed to reduce damage to the nervous tissue in the course of stroke.

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Section: The Role Of Nlrp3 Inflammasomementioning

confidence: 99%

<p>The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke</p>

Pawluk¹,

Woźniak²,

Grześk³

et al. 2020

CIA

116

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“…Targeting against the assembly and activity of the NLRP3 inflammasome is a potential and novel therapy for inflammasome-associated diseases, especially for cardiovascular diseases [55][56][57][58][59][60]. Some studies have indicated that blocking S194 phosphorylation can prevent NLRP3 inflammasome activation.…”

Section: Discussionmentioning

confidence: 99%

NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases

Tong

Wang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background/Aims. NLRP3 inflammasome, an inflammasome which consists of nucleotide-binding oligomerization domain- (Nod-) like receptor3 (NLRP3) scaffold, apoptosis-associated speck-like protein (ASC) containing a CARD adaptor, and pro-caspase-1, is assembled after the cytoplasmic leucine-rich repeats (LRRs) of NLRP3 sense pathogens or danger signals. In recent years, the role of inflammasome in cardiovascular diseases has attracted mounting attention, and the in-depth study of its mechanism is gradually clear. Materials. The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response. We made a mini-review on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases systematically based on the recent research studies. Discussion. The inflammasome plays an indispensable role in the development of atherosclerosis, coronary heart diseases (CHD), and heart ischemia-reperfusion (I/R) injury, and NLRP3 inflammasome may become a new target for the prevention and treatment of cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat cardiovascular diseases. Conclusion. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases, which may supply some important clues for future therapies and novel drug targets for cardiovascular diseases.

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“…Inflammasomes are polymorphic complexes formed by pattern recognition receptors activated by various physiological or pathogenic stimuli, which makes them an important component of the innate immune response with the ability to clear pathogens and damaged cells [7]. The NLRP3 (nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing, NLRP) inflammasome is an innate immune cell sensor that belongs to the NLR family [8]. The NLRP3 inflammasome is considered to be the most characteristic and contains the sensor molecule NLRP3, an apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC), and pro-caspase-1 [9].…”

Section: The Nlrp3 Inflammasomementioning

confidence: 99%

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

Ding

et al. 2019

Biomolecules

158

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The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual’s gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes.

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NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

Cited by 112 publications

References 136 publications

<p>The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke</p>

<p>The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke</p>

NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

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