NLRP3 inflammasome activity is required for wound healing after burns

Regulation of glycolysis and the Warburg effect in wound healing

“…Skin was obtained at various time points after burn (1 specimen per patient) and grouped into postburn day ranges in order to increase sample size ( Table 1 and Table 2). Day ranges were selected based on previous work (15).…”

“…Interestingly, upregulation in glycolysis and glucose uptake is also seen in conditions of physiologic healing and burn injuries, although to a lesser extent (8)(9)(10)(11)(12). In the context of burns, the process of cutaneous wound healing is initiated by an inflammatory response at the site of injury generated by nucleotide-binding and oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome, the master regulator of inflammatory and metabolic responses (13)(14)(15). Upon activation, NLRP3 serves as a danger-sensing platform, facilitating cleaved caspase-1 processing and promoting the release of IL-1β and IL-18.…”

Immunological approaches and therapy in burns (Review)

“…No increases in IL-6 and IL-1β or anti-inflammatory cytokines were observed. Corroborating the two conclusions, it can be stated that the lack of expression of the NLRP3 inflammasome after burn leads to increased chemotaxis and activity of macrophages ( 68 ).…”

“…This inflammasome has an effect on the balance between lipolysis and lipogenesis. Thus, the deficiency of expression of NLRP3, at one hour post-burn, may influence lipid metabolism, in the sense of affecting de novo lipid synthesis and shifting the balance to lipolysis (68,69). It is also hypothesized that inhibition of NLRP3 action would decrease the inflammatory response in local tissues (68,70).…”

“…Its expression is positively correlated with mortality ( 67 ). Vinaik et al , observed that NLRP3 inflammasome has an intense activity in the adipose tissue of the burned patients within the first 7 days after the burn ( 68 ).…”