NLRP12‐PANoptosome in haemolytic, infectious and inflammatory diseases

Tweedell, Rebecca E.; Kanneganti, Thirumala‐Devi

doi:10.1002/ctm2.1409

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…The expression of the human NLR family pyrin domain containing 12 (NLRP12) was first identified in monocytes, macrophages, and granulocytes. During infections, NLRP12 serves as a cytosolic sensor that initiates the assembly of inflammasomes [52]. Initial investigations have linked truncated NLRP12 mutations to hereditary periodic fevers characterized by recurrent fevers, joint pain, and skin urticaria.…”

Section: The Nlrp12 Inflammasomementioning

confidence: 99%

“…Moreover, by forming complexes, NLRP12 inhibits the activation of the noncanonical NF-κB pathway and induces proteasome-mediated degradation of NF-κB-inducing kinase (NIK) [53]. During the inflammatory process, NLRP12 regulates immune cell migration by maintaining peripheral dendritic cells and neutrophils in a migration-competent state [53], and mice lacking NLRP12 are more likely to have colon inflammation, colorectal tumors, and atypical neuroinflammation [52].…”

Section: The Nlrp12 Inflammasomementioning

confidence: 99%

“…Recent studies have revealed that NLRP12 is an inhibitor of autoinflammatory diseases and plays a role in a range of processes such as inflammatory bone mineral loss, arthritis, alcoholic liver injury-mediated apoptosis of hepatocytes, pathogen immune response, and the regulation of intestinal flora, such as in the maintenance of beneficial microbes involved in the inhibition of inflammation [54]. The most recent evidence highlights that heme release by red blood cell lysis during inflammatory disease, infection, or other cellular damages can activate a specific NLRP12-mediated PANoptosis, an innate immune inflammatory cell death pathway mediated by cell death-inducing complexes called PANoptosomes [52,55].…”

Section: The Nlrp12 Inflammasomementioning

confidence: 99%

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Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases

Sultana,

Viet,

Amin

et al. 2023

Future Pharmacology

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Inflammasomes, a group of multiprotein complexes, are essential in regulating inflammation and immune responses. Several inflammasomes, including nucleotide-binding domain leucine-rich repeat-containing protein 1 (NLRP1), NLRP3, NLRP6, NLRP7, NLRP12, interferon-inducible protein 16 (IFI16), NOD-like receptor family CARD domain-containing protein 4 (NLRC4), absent in melanoma 2 (AIM2), and pyrin, have been studied in various inflammatory diseases. Activating inflammasomes leads to the processing and production of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18. The NLRP3 inflammasome is the most extensively studied and well characterized. Consequently, targeting inflammasomes (particularly NLRP3) with several compounds, including small molecule inhibitors and natural compounds, has been studied as a potential therapeutic strategy. This review provides a comprehensive overview of different inflammasomes and their roles in six inflammatory diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, atherosclerosis, type 2 diabetes, and obesity. We also discussed different strategies that target inflammasomes to develop effective therapeutics.

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Section: The Nlrp12 Inflammasomementioning

confidence: 99%

Section: The Nlrp12 Inflammasomementioning

confidence: 99%

Section: The Nlrp12 Inflammasomementioning

confidence: 99%

See 1 more Smart Citation

Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases

Sultana,

Viet,

Amin

et al. 2023

Future Pharmacology

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“…Previous studies have demonstrated that activated ZBP1 serves as a master regulator of IAV-induced NLRP3 inflammasome activation and inflammatory cell death, PANoptosis [9,10,12]. PANoptosis is a unique innate immune, lytic and inflammatory cell death pathway driven by caspases and RIPKs that is regulated by the multiprotein PANoptosome complex [25]. The IAV-induced ZBP1-PANoptosome contains several components, including RIPK3 and CASP8 [9,10,12].…”

Section: Loss Of Necroptosis Executioner Mlkl Does Not Protect Macrop...mentioning

confidence: 99%

ZBP1 Drives IAV-Induced NLRP3 Inflammasome Activation and Lytic Cell Death, PANoptosis, Independent of the Necroptosis Executioner MLKL

Malireddi,

Sharma,

Bynigeri

et al. 2023

Viruses

Self Cite

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Influenza A virus (IAV) continues to pose a significant global health threat, causing severe respiratory infections that result in substantial annual morbidity and mortality. Recent research highlights the pivotal role of innate immunity, cell death, and inflammation in exacerbating the severity of respiratory viral diseases. One key molecule in this process is ZBP1, a well-recognized innate immune sensor for IAV infection. Upon activation, ZBP1 triggers the formation of a PANoptosome complex containing ASC, caspase-8, and RIPK3, among other molecules, leading to inflammatory cell death, PANoptosis, and NLRP3 inflammasome activation for the maturation of IL-1β and IL-18. However, the role for other molecules in this process requires further evaluation. In this study, we investigated the role of MLKL in regulating IAV-induced cell death and NLRP3 inflammasome activation. Our data indicate IAV induced inflammatory cell death through the ZBP1-PANoptosome, where caspases and RIPKs serve as core components. However, IAV-induced lytic cell death was only partially dependent on RIPK3 at later timepoints and was fully independent of MLKL throughout all timepoints tested. Additionally, NLRP3 inflammasome activation was unaffected in MLKL-deficient cells, establishing that MLKL and MLKL-dependent necroptosis do not act upstream of NLRP3 inflammasome activation, IL-1β maturation, and lytic cell death during IAV infection.

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Overexpression of NLRP12 enhances antiviral immunity and alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-γ signaling

Jiang,

Shen,

et al. 2024

International Immunopharmacology

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NLRP12‐PANoptosome in haemolytic, infectious and inflammatory diseases

Cited by 3 publications

References 10 publications

Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases

Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases

ZBP1 Drives IAV-Induced NLRP3 Inflammasome Activation and Lytic Cell Death, PANoptosis, Independent of the Necroptosis Executioner MLKL

Overexpression of NLRP12 enhances antiviral immunity and alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-γ signaling

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