NKT cell subsets in infection and inflammation

Chan, Weng Onn; Pejnović, Nada; Liew, Tze Vun; Lee, Christine A.; Groves, Richard; Hamilton, Hamish

doi:10.1016/s0165-2478(02)00223-7

Cited by 43 publications

(35 citation statements)

References 41 publications

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“…Natural killer T (NK-T) cells are a subset of lymphocytes that express T-cell receptors and natural killer cell receptors, such as CD94 and CD161 and an invariant TCR ␣-chain (V␣24-J␣Q in humans) [37][38][39]. NK-T cells are thought to be innate memory cells, playing important roles in initiating and regulating immune responses [40,41].…”

Section: Increasingly Components Of the Innate Immune Pathway Are Bementioning

confidence: 99%

Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogenesis

Chamian

Krueger

2004

Current Opinion in Rheumatology

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Section: Increasingly Components Of the Innate Immune Pathway Are Bementioning

confidence: 99%

Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogenesis

Chamian

Krueger

2004

Current Opinion in Rheumatology

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“…Therefore, the reciprocal upregulation of receptors partly explains how IL-12 and IL-18 synergize in the production of IFN-␥ by Th1 cells [12]. Furthermore, IL-18R expression is a marker of IFN-␥ producing NKT cells [13].…”

Section: Introductionmentioning

confidence: 99%

Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft

et al. 2005

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“…The discovery that CD1d presentation of a-galactosylceramide (a-GalCer) rapidly activates murine and human iNKT cells has greatly increased our understanding of the potential role that iNKT cells play in host immunity (7,8). The synthetic glycosphingolipid a-GalCer is a potent iNKT cell agonist, and even though it is not a natural ligand for iNKT cells, a-GalCer and its analogs are commonly used experimentally (9).…”

mentioning

confidence: 99%

“…For example, a-GalCer has been used to analyze the immunomodulatory properties of activated iNKT cells in mice and patients with malignancies (14)(15)(16). Administration of a-GalCer activates both the innate and adaptive immune system and has raised the possibility of using a-GalCer for therapeutic purposes (8,17).…”

mentioning

confidence: 99%

α-Galactosylceramide as a Therapeutic Agent for PulmonaryMycobacterium tuberculosisInfection

Sada‐Ovalle¹,

Sköld²,

Tian³

et al. 2010

Am J Respir Crit Care Med

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Rationale: Invariant natural killer T (iNKT) cells are a unique subset of T cells that recognize lipid antigens presented by CD1d molecules. Recent studies have shown that iNKT cells can protect mice against Mycobacterium tuberculosis (Mtb) infection. We sought to determine whether pharmacological activation of iNKT cells by a-galactosylceramide (a-GalCer) could be used to treat tuberculosis (TB). Objectives: We hypothesized that a-GalCer, either alone or in combination with isoniazid, could be used to treat pulmonary TB. Methods: The ability of a-GalCer-activated iNKT cells to suppress Mtb replication was evaluated using an in vitro coculture system. To test its potency in vivo, mice infected with virulent Mtb were treated with a-GalCer alone or in combination with isoniazid. Measurements and Main Results: Quantitative colony-forming unit counts were compared for both experimental systems. Our results show that a-GalCer plus isoniazid controls bacterial growth better than a-GalCer or INH alone, and single or multiple a-GalCer administrations prolong the survival of the mice infected via the aerosol route.Conclusions: Our results demonstrate that a-GalCer administration can improve the outcome of Mtb infection, even when transmitted by the aerosol route. However, a combination of isoniazid and a-GalCer treatment has a synergistic effect on infection control. We conclude that more efficient treatment of TB will be achieved through a combination of classic chemotherapy and modulation of the host immune response.

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NKT cell subsets in infection and inflammation

Cited by 43 publications

References 41 publications

Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogenesis

Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogenesis

Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft

α-Galactosylceramide as a Therapeutic Agent for PulmonaryMycobacterium tuberculosisInfection

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