NK1.1+ Cells and IL-22 Regulate Vaccine-Induced Protective Immunity against Challenge with <i>Mycobacterium tuberculosis</i>

Dhiman, Rohan; Periasamy, Sivakumar; Barnes, Peter F.; Jaiswal, Ankita Garg; Paidipally, Padmaja; Barnes, Amanda B.; Tvinnereim, Amy; Vankayalapati, Ramakrishna

doi:10.4049/jimmunol.1102833

Cited by 63 publications

(73 citation statements)

References 45 publications

(50 reference statements)

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“…These studies emphasize the importance of investigating memory NK cells in TB vaccine assessments. In support of this, mice vaccinated with BCG demonstrated increased numbers of IFN-␥-expressing NK 1.1 cells, and their depletion led to reduced vaccination efficacy following M. tuberculosis challenge (59).…”

Section: Other Immune Cells Potentially Correlating With Protectionmentioning

confidence: 99%

Quest for Correlates of Protection against Tuberculosis

Bhatt

Verma

Ellner

et al. 2015

Clin. Vaccine Immunol.

116

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A major impediment to tuberculosis (TB) vaccine development is the lack of reliable correlates of immune protection or biomarkers that would predict vaccine efficacy. Gamma interferon (IFN-␥) produced by CD4 ؉ T cells and, recently, multifunctional CD4 ؉ T cells secreting IFN-␥, tumor necrosis factor (TNF), and interleukin-2 (IL-2) have been used in vaccine studies as a measurable immune parameter, reflecting activity of a vaccine and potentially predicting protection. However, accumulating experimental evidence suggests that host resistance against Mycobacterium tuberculosis infection is independent of IFN-␥ and TNF secretion from CD4 ؉ T cells. Furthermore, the booster vaccine MVA85A, despite generating a high level of multifunctional CD4؉ T cell response in the host, failed to confer enhanced protection in vaccinated subjects. These findings suggest the need for identifying reliable correlates of protection to determine the efficacy of TB vaccine candidates. This article focuses on alternative pathways that mediate M. tuberculosis control and their potential for serving as markers of protection. The review also discusses the significance of investigating the natural human immune response to M. tuberculosis to identify the correlates of protection in vaccination.

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Section: Other Immune Cells Potentially Correlating With Protectionmentioning

confidence: 99%

Quest for Correlates of Protection against Tuberculosis

Bhatt

Verma

Ellner

et al. 2015

Clin. Vaccine Immunol.

116

View full text Add to dashboard Cite

show abstract

“…135 When used in combination with IL-2 and IL-12, glutathione enhances NK cell functions in controlling M. tuberculosis infection, 133 possibly by increasing the expression of NK cytotoxic ligands (such as FasL and CD40L). 136 Dhiman et al 137 found in their research that NK1.1 1 cells and IL-22 contribute to the efficacy of vaccine-induced protective immunity against M. tuberculosis.…”

Section: Pulmonary Nk Cells In Lung Diseasesmentioning

confidence: 99%

NK cells in immunotolerant organs

Sun

Tian

et al. 2013

Cell Mol Immunol

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Organs such as the liver, uterus and lung possess hallmark immunotolerant features, making these organs important for sustaining self-homeostasis. These organs contain a relatively large amount of negative regulatory immune cells, which are believed to take part in the regulation of immune responses. Because natural killer cells constitute a large proportion of all lymphocytes in these organs, increasing attention has been given to the roles that these cells play in maintaining immunotolerance. Here, we review the distribution, differentiation, phenotypic features and functional features of natural killer cells in these immunotolerant organs, in addition to the influence of local microenvironments on these cells and how these factors contribute to organ-specific diseases.

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“…Although less well-studied, IL-22 has been shown to induce protection. IL-22 produced from NK cells could inhibit M. tuberculosis growth inside the human macrophages by increasing phagolysosomal fusion [78,79]. In fact, in cattle vaccine/ challenge protocols, enhanced IL-17A and IL-22 production observed after vaccination, but before challenge are correlated with the success of vaccine (impediment of pathology) following successive M. bovis challenge [42,52,80].…”

Section: Immunological Correlates Of Protection Studies In Cattlementioning

confidence: 99%

Cattle as Experimental Model to Study Immunopathogenesis of Tuberculosis

Mehta¹,

Dharra²,

Thakur³

2017

Mycobact Dis

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Various animal models are used to study the immunology, genetics and molecular biology of tuberculosis (TB) as well as for testing the new vaccines and drugs. Mice are widely used to study the immunology of chronic TB infection, while guinea pigs are used for aerosol TB infection and rabbits are used to study the lung cavitations. Cattle are natural host to Mycobacterium bovis infection, which act as a connecting link between the small laboratory animals and human counterparts for testing the vaccine efficacy. By using cattle as an experimental model, the disease outcome is understood through natural infection with M. bovis and a comparison can be made with M. tuberculosis infection. In this manuscript, the utility of cattle in understanding the progression of disease and the immunological correlates to evaluate the protective efficacy of vaccines are described.

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NK1.1+ Cells and IL-22 Regulate Vaccine-Induced Protective Immunity against Challenge with Mycobacterium tuberculosis

Cited by 63 publications

References 45 publications

Quest for Correlates of Protection against Tuberculosis

Quest for Correlates of Protection against Tuberculosis

NK cells in immunotolerant organs

Cattle as Experimental Model to Study Immunopathogenesis of Tuberculosis

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