NK-KIR Transcript Kinetics Correlate With Acute Graft-Versus-Host Disease Occurrence After Allogeneic Bone Marrow Transplantation

Denis, L.; Gagne, Katia; Gueglio, B.; Kerdudou, Nolwenn; Milpied, Noël; Simon, Philippe; Folléa, Gilles; Bonneville, Marc; Harousseau, Jean‐Luc; Bignon, Jean-Denis

doi:10.1016/j.humimm.2005.01.008

Cited by 10 publications

(5 citation statements)

References 45 publications

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“…28,29 A more detailed understanding of KIR3DL1 expression is also necessary to determine the precise role of these receptors in transplantation and disease association. To date, the profile of KIR3DL1 alleles on NK cells has been investigated in many populations.…”

Section: Introductionmentioning

confidence: 99%

KIR3DL1 genetic diversity and phenotypic variation in the Chinese Han population

Tao

Ying

et al. 2013

Genes Immun

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Allelic polymorphism and expression variation of killer cell immunoglobulin-like receptor (KIR) 3DL1 on natural killer (NK) cells differ among populations. To determine whether the phenotypic variants are due to KIR polymorphism, transcription or copy number, the allelic polymorphism, mRNA levels and antigen expression of KIR3DL1 were assessed in 162 individuals. We characterized 13 KIR3DL1 alleles, five of which were novel. In addition, 21 genotypes were identified. The correlation between the binding patterns of NK cells to anti-KIR3DL1 and KIR3DL1 alleles was also examined. NK cells with different 3DL1 alleles showed distinct binding levels to anti-KIR3DL1. The binding frequencies of NK cells to anti-KIR3DL1 were not accordant with their binding levels, but both associated with the allele copy numbers. The mRNA expression amounts of individuals with two copy alleles were higher than those of individuals with one copy allele. Our data indicate that both the allele copy number and polymorphism of KIR3DL1 influence the antigen expression on the NK-cell surface, but only the copy number was associated with mRNA expression.

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Section: Introductionmentioning

confidence: 99%

KIR3DL1 genetic diversity and phenotypic variation in the Chinese Han population

Tao

Ying

et al. 2013

Genes Immun

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“…In this regard, KIR3DL1 and KIR3DL2 were particularly illustrative with 11 and 12 alleles, respectively (17, 21–24). Nevertheless, it is well established that individual NK cell clones express only some of the KIR genes that are mostly regulated at the transcriptional level (25), as recently observed in haematopoietic stem cell transplantation (HSCT) (26). Consequently, each NK cell in an individual can express a unique receptor combination, which varies in KIR receptor number [ranging from one to eight (17)] and in KIR receptor function (inhibitory or activating).…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and Réunion

et al. 2005

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Killer cell immunoglobulin-like receptors (KIRs) belong to a diverse family of natural killer (NK) cell receptors recognizing human leukocyte antigen (HLA) class I molecules. Due to this functional link, KIR molecules are expected to display a high polymorphism, such as their HLA ligands. Moreover, many studies conducted in mouse and human models have shown that NK-KIR receptors play an important role in haematopoietic stem cell transplantation (HSCT). A beneficial impact of peculiar KIR ligand (HLA) mismatching has been reported suggesting a role to this combinatory HLA-KIR polymorphism. It is thus important to investigate KIR diversity in various human populations. To this end, we used polymerase chain reaction-sequence-specific primers to evaluate KIR gene in five selected populations (France, Guadeloupe, Senegal, Finland and Réunion). Genotypic and haplotypic frequencies were computed, as well as genetic distances and dendrogram (phylip package). These data illustrate the genetic relationship of these five populations through the KIR polymorphism. Results revealed a wide diversity in KIR gene frequencies in Guadeloupe and Réunion, and a high specificity in Senegal. The obtained dendrogram indicated small genetic distances between France, Guadeloupe and Réunion as well as between France and Finland. Senegal showed a distant genetic relationship with the other countries and, interestingly, an inverted ratio of coding/non-coding (KIR2DS4/1D) alleles compared with Caucasians. These data expose the broad diversity in KIR genes worldwide and show that KIR genes are pertinent tools in human population genetics. If the role of KIR donor-recipient incompatibilities is confirmed, KIR diversity according to ethnicity should be taken into account during the selection of HSCT donors.

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“…28 Therefore, further investigation of KIR expression at the cellular level, rather than by KIR genotyping alone, is warranted. [28][29][30] Moreover, in a subsequent analysis the presence of single or multiple activating KIRs was not found to influence the development of CDC between the different inhibitory KIR score groups in our patients (data not shown).…”

Section: Discussionmentioning

confidence: 59%

Influence of killer immunoglobulin-like receptor/HLA ligand matching on achievement of T-cell complete donor chimerism in related donor nonmyeloablative allogeneic hematopoietic stem cell transplantation

Sobecks

Ball

Askar

et al. 2008

Bone Marrow Transplant

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NK-KIR Transcript Kinetics Correlate With Acute Graft-Versus-Host Disease Occurrence After Allogeneic Bone Marrow Transplantation

Cited by 10 publications

References 45 publications

KIR3DL1 genetic diversity and phenotypic variation in the Chinese Han population

KIR3DL1 genetic diversity and phenotypic variation in the Chinese Han population

Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and Réunion

Influence of killer immunoglobulin-like receptor/HLA ligand matching on achievement of T-cell complete donor chimerism in related donor nonmyeloablative allogeneic hematopoietic stem cell transplantation

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