NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage
Harikrishnan Balachandran,
Kyle Kroll,
Karen Terry
et al.
Abstract:Natural killer (NK) cells play a critical role in virus control. However, it has remained largely unclear whether NK cell mobilization in SARS-CoV-2 infections is beneficial or pathologic. To address this deficit, we employed a validated experimental NK cell depletion non-human primate (NHP) model with SARS-CoV-2 Delta variant B.1.617.2 challenge. Viral loads (VL), NK cell numbers, activation, proliferation, and functional measures were evaluated in blood and tissues. In non-depleted (control) animals, infecti… Show more
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