NK cells in patients with chronic rhinosinusitis show decreased maturity and limited expression of functional receptors

Kaczmarek, Mariusz; Wasicka, Karolina; Chou, Jadzia Tin-Tsen; Popowicz, P.; Rzetelska, Zuzanna; Łagiedo‐Żelazowska, Małgorzata; Piwowarczyk, Krzysztof; Leszczyńska, Małgorzata

doi:10.1016/j.imbio.2019.11.025

Cited by 6 publications

(9 citation statements)

References 22 publications

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“…Furthermore, the AR NKG2D was expressed at lower frequencies (lower percentages of NKG2D + cells) and lower density of expression in the nasal mucosa and the polyps compared to PB (populations negative for NKG2D were identified in the tissues). Finally, the percentage of NK cells among lymphocytes (mean: 33%) was significantly higher in the polyps than in PB (20).…”

Section: Nk Cells In the Upper Airwaysmentioning

confidence: 84%

“…In human, the articles were mostly reporting on the investigation of NK cells in chronic rhinosinusitis, an inflammatory state of the mucosa of the nose and the sinuses (18) with a significant impact on quality of life. Two different forms, one with nasal polyps and one without nasal polyps, are distinguished (19,20). Bacterial pathogens are considered as one of the etiological factors in this disease (18).…”

Section: Nk Cells In the Upper Airwaysmentioning

confidence: 99%

“…The authors demonstrated that the PB NK cells from the patients had decreased effector functions compared to the healthy controls, with the treatment-resistant individuals being most severely affected ( 18 ). The recent manuscript by Kaczmarek et al ( 20 ) reported not only on PB NK cells, but also on those from nasal mucosa and from nasal polyps. However, the exploitation of the material was limited to CD3 – CD56 + CD16 + events, which excluded the population of CD56 bright CD16 – NK cells that might be numerically well represented in these tissues.…”

Section: Nk Cells In the Upper Airwaysmentioning

confidence: 99%

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Airway Natural Killer Cells and Bacteria in Health and Disease

2020

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Natural killer (NK) cells are innate lymphoid cells at the interface between innate and adaptive immunity and mostly studied for their important roles in viral infections and malignant tumors. They can kill diseased cells and produce cytokines and chemokines, thereby shaping the adaptive immune response. Nowadays, NK cells are considered as a strong weapon for cancer immunotherapy and can for example be transduced to express tumor-specific chimeric antigen receptors or harnessed with therapeutic antibodies such as the so-called NK engagers. Whereas a large body of literature exists about the antiviral and antitumoral properties of NK cells, their potential role in bacterial infections is not that well delineated. Furthermore, NK cells are much more heterogeneous than previously thought and have tissue-characteristic features and phenotypes. This review gives an overview of airway NK cells and their position within the immunological army dressed against bacterial infections in the upper and predominantly the lower respiratory tracts. Whereas it appears that in several infections, NK cells play a non-redundant and protective role, they can likewise act as rather detrimental. The use of mouse models and the difficulty of access to human airway tissues for ethical reasons might partly explain the divergent results. However, new methods are appearing that are likely to reduce the heterogeneity between studies and to give a more coherent picture in this field.

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Section: Nk Cells In the Upper Airwaysmentioning

confidence: 84%

Section: Nk Cells In the Upper Airwaysmentioning

confidence: 99%

Section: Nk Cells In the Upper Airwaysmentioning

confidence: 99%

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Airway Natural Killer Cells and Bacteria in Health and Disease

2020

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“…Natural killer (NK) cells are important immune cells with anti‐viral and anti‐tumor effects, which can also participate in allergic inflammation by regulating Th2 inflammation and eosinophil migration 160 . A Polish study utilizing flow cytometry to detect NK cells in nasal polyps, nasal mucosa, and peripheral blood showed increased numbers of immature NK cells in 36 patients with CRSwNP, 13 patients with CRSsNP, and 15 controls 161 . Ginsenoside F1, which are molecular metabolites derived from the Panax ginseng root, also reduced eosinophilic inflammation in CRS by activating NK cell activity 162 .…”

Section: Effect Of Hypoxia On Immune Cellsmentioning

confidence: 99%

The role of hypoxia in the pathophysiology of chronic rhinosinusitis

Zhong

Seah

Liu

et al. 2022

Allergy

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Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal cavity and the paranasal sinuses. [1][2][3][4] It has a significant impact on living and working conditions, affecting about 5%-12% of the general population. [5][6][7] Common complaints of such patients include nasal congestion, nasal discharge, altered sense of smell, facial pain, and facial pressure. The United States conservatively estimates that spending on CRS amounts up to $30 billion each year, inevitably creating a huge economic burden on society. 7 From an etiological point of view, CRS can be classified into primary and secondary forms. 8 Primary CRS is characterized by chronic inflammation of the nasal cavity and paranasal sinuses, where an obvious secondary causative factor is absent. Secondary

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“…Thus, we fully agree with Gelardi et al that scientific attention in CRS should be given to the role of MCs. We additionally postulate that the role of other immune cells like macrophages, NK, dendritic, and T and B cells 4 should be evaluated more carefully in CRS, although the current EPOS 2020 guidelines sub-classify CRS based on the eosinophil infiltration as non-eosinophilic (neCRS) or eosinophilic (eCRS) 5 . In our paper, we followed the classification and found a negative correlation between SWI/SNF subunit abundance in the epithelium and eosinophil count, thus supporting the role of SWI/SNF in eCRS 6 .…”

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confidence: 99%