NK- and T-cell lymphoma of the nasal cavity and paranasal sinuses in Denmark 1980–2017: a nationwide cohort study

Eriksen, Patrick René Gerhard; Clasen‐Linde, Erik; Brown, Peter de Nully; Haunstrup, Laura; Christoffersen, Mette; Asdahl, Peter H.; Thomsen, Troels Møller; Buchwald, Christian von; Heegaard, Steffen

doi:10.1080/10428194.2022.2087069

Cited by 4 publications

(8 citation statements)

References 24 publications

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“…9,10 However, some differences were observed in comparison with a recent large-scale cohort study in Europe. 11 First, the median age of the patients in ENKL in Europe was 65.7 years, which was higher than that of the patients in our study and previous reports in Asia and Latin America. 9,10 Extranodal NK/T-cell lymphoma, nasal type, is a rare disease in Europe, and race, Epstein–Barr virus strain mutations, and environmental factors are considered as some of the reasons for this geographical difference.…”

Section: Discussioncontrasting

confidence: 74%

“…9 In contrast, its incidence is less than 1% in Western countries, 10 constituting approximately 0.2% of all NHL cases in a recent European study. 11 Extranodal NK/T-cell lymphoma, nasal type, has a male predilection, and patients were usually in their 40s or 50s at the time of diagnosis, 9 which was slightly lower than those who have other types of lymphoma. Extranodal NK/T-cell lymphoma, nasal type, frequently occurs within the nasal cavity and pharynx: 80% of nasal/paranasal ENKLs involve the nasal cavity, followed by the maxillary sinus (6%).…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Extranodal NK/T-Cell Lymphoma, Nasal Type, Compared with Nasal Diffuse Large B-cell Lymphoma

Mori

Akutsu

Saito

et al. 2023

Clin Med Insights Oncol

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Background: Extranodal NK/T-cell lymphoma, nasal type (ENKL), is an aggressive tumour with poor prognosis. Its early diagnosis may improve the prognosis of patients; however, it is often overlooked in many cases and misdiagnosed as an inflammatory sinus disease during its initial stage. Identifying the clinical characteristics of ENKL may aid otorhinolaryngologists in indicating cases early for a pathologic examination. In this study, we aimed to investigate the clinical characteristics of ENKL compared with that of diffuse large B-cell lymphoma (DLBCL), which is the most common nasal malignant lymphoma. Methods: The backgrounds, clinical symptoms, blood test results, and computed tomography images of patients with nasal/paranasal malignant lymphoma in our hospital between 2012 and 2017 were investigated. The characteristics of ENKL and nasal DLBCL were compared to differentiate them. Results: A total of 27 patients with nasal cavity and/or paranasal sinus lymphoma were included. Extranodal NK/T-cell lymphoma, nasal type, was diagnosed in 10 patients, while DLBCL was diagnosed in 17 patients. The median age of patients with ENKL was significantly lower than that of patients with DLBCL. All patients with ENKL had a unilateral lesion in the nasal cavity, with most located at the inferior turbinate. They also experienced nasal symptoms with significantly higher incidence of nasal obstruction and tendency of bleeding. Conclusion: ENKL was often unilateral and caused nasal obstruction, unlike DLBCL. Those who are younger in age and have sinonasal tumour with unilateral nasal obstruction and bleeding should be considered for early and repeated biopsies at multiple sites, with ENKL taken into consideration.

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Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Characteristics of Extranodal NK/T-Cell Lymphoma, Nasal Type, Compared with Nasal Diffuse Large B-cell Lymphoma

Mori

Akutsu

Saito

et al. 2023

Clin Med Insights Oncol

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“…Among the 36 patients with ENKTCL in the nose-Waldeyer’s ring in the present study, the lesions of 26 patients were found in the nasal cavity and paranasal sinuses, with irregular or cast growth, and is easy to invade the nasal septum, turbinate, sinus complex, and surrounding bone. Among the 53 patients with DLBCL, the lesions of 35 patients were found in the Waldeyer’s ring, showing diffuse soft tissue thickening or prominent soft tissue mass, with little infiltration and growth deep into the tissues of pharyngeal wall ( 4 , 23 , 29 ). ENKTCL is commonly presented with diffuse infiltration, while DLBCL is mostly diagnosed with localized mass; the edge of ENKTCL was relatively blurred when in comparison with DLBCL ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, it has a tendency of extranodal transmission, with rapid progression and poor prognosis. Another major pathological type of NHL at this site is diffuse large B cell lymphoma (DLBCL), which accounts for about 56% of NHL and has a relatively good prognosis ( 4 ). It has been demonstrated by several retrospective studies that ENKTCL was more invasive and had poorer prognosis than DLBCL with regards to their clinical features.…”

Section: Introductionmentioning

confidence: 99%

A diagnostic scoring model of ENKTCL in the nose-Waldeyer’s ring based on logistic regression: Differential diagnosis from DLBCL

Xiang

Huang²,

Feng³

et al. 2023

Front. Oncol.

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ObjectiveTo establish a logistic regression model based on CT and MRI imaging features and Epstein-Barr (EB) virus nucleic acid to develop a diagnostic score model to differentiate extranodal NK/T nasal type (ENKTCL) from diffuse large B cell lymphoma (DLBCL).MethodsThis study population was obtained from two independent hospitals. A total of 89 patients with ENKTCL (n = 36) or DLBCL (n = 53) from January 2013 to May 2021 were analyzed retrospectively as the training cohort, and 61 patients (ENKTCL=27; DLBCL=34) from Jun 2021 to Dec 2022 were enrolled as the validation cohort. All patients underwent CT/MR enhanced examination and EB virus nucleic acid test within 2 weeks before surgery. Clinical features, imaging features and EB virus nucleic acid results were analyzed. Univariate analyses and multivariate logistic regression analyses were performed to identify independent predictors of ENKTCL and establish a predictive model. Independent predictors were weighted with scores based on regression coefficients. A receiver operating characteristic (ROC) curve was created to determine the diagnostic ability of the predictive model and score model.ResultsWe searched for significant clinical characteristics, imaging characteristics and EB virus nucleic acid and constructed the scoring system via multivariate logistic regression and converted regression coefficients to weighted scores. The independent predictors for ENKTCL diagnosis in multivariate logistic regression analysis, including site of disease (nose), edge of lesion (blurred), T2WI (high signal), gyrus like changes, EB virus nucleic acid (positive), and the weighted score of regression coefficient was 2, 3, 4, 3, 4 points. The ROC curves, AUCs and calibration tests were carried out to evaluate the scoring models in both the training cohort and the validation cohort. The AUC of the scoring model in the training cohort were 0.925 (95% CI, 0.906-0.990) and the cutoff point was 5 points. In the validation cohort, the AUC was 0.959 (95% CI, 0.915-1.000) and the cutoff value was 6 points. Four score ranges were as follows: 0-6 points for very low probability of ENKTCL, 7-9 points for low probability; 10-11 points for middle probability; 12-16 points for very high probability.ConclusionThe diagnostic score model of ENKTCL based on Logistic regression model which combined with imaging features and EB virus nucleic acid. The scoring system was convenient, practical and could significantly improve the diagnostic accuracy of ENKTCL and the differential diagnosis of ENKTCL from DLBCL.

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“…Sie können primär in der Orbita selbst entstehen (Übersicht bei [451]) oder in den Nasennebenhöhlen und auf die Orbita übergreifen. Während es sich bei den Lymphomen in der Orbita meist um maligne B-Zell-Lymphome handelt [458] (mit dem diffus großzelligen Lymphom als häufigsten Vertreter), werden im Bereich der Nasenhaupthöhle auch T-Zell-Lymphome angetroffen [459,460], die eine hohe Aggressivität mit einer schlechteren Prognose als die B-Zell-Lymphome aufweisen [460]. In der Orbita können alle Strukturen infiltriert werden mit der Folge einer Propoptose, Chemosis, Diplopie, Epiphora und ggfls.…”

Section: Maligne Lymphomeunclassified

Interdisziplinäre Therapie der Erkrankungen der Orbita

Eckstein,

Welkoborsky

2024

Laryngorhinootologie

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ZusammenfassungDie Diagnostik und Therapie von Erkrankungen der Orbita ist eine interdisziplinäre Aufgabe, an der u.a. die Fachdisziplinen HNO-Heilkunde, Augenheilkunde, Radiologie, Strahlentherapie, MKG-Chirurgie, Endokrinologie und Pädiatrie beteiligt sind. Der vorliegende Übersichtsartikel stellt eine Zusammenstellung der häufigsten Erkrankungen dar, mit denen die Fachdisziplinen HNO-Heilkunde und Augenheilkunde interdisziplinär befasst sind. Es werden die akuten entzündlichen Erkrankungen incl. orbitaler Komplikationen, die autoimmunologischen Erkrankungen der Orbita incl. der endokrinen Orbitopathie, und die tumorösen Erkrankungen besprochen. Neben der Diagnostik und der Beschreibung der Klinik wird besonderes Augenmerk auf die interdisziplinäre Therapie gelegt. Abgerundet wird der Übersichtsartikel mit der Beschreibung der wichtigsten chirurgischen Zugangswege zur Orbita, ihre Indikationen und mögliche Komplikationen. Die Autoren haben versucht, trotz der knappen Darstellung die relevanten Fakten zu beschreiben.

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NK- and T-cell lymphoma of the nasal cavity and paranasal sinuses in Denmark 1980–2017: a nationwide cohort study

Cited by 4 publications

References 24 publications

Characteristics of Extranodal NK/T-Cell Lymphoma, Nasal Type, Compared with Nasal Diffuse Large B-cell Lymphoma

Characteristics of Extranodal NK/T-Cell Lymphoma, Nasal Type, Compared with Nasal Diffuse Large B-cell Lymphoma

A diagnostic scoring model of ENKTCL in the nose-Waldeyer’s ring based on logistic regression: Differential diagnosis from DLBCL

Interdisziplinäre Therapie der Erkrankungen der Orbita

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