Nivolumab‐induced erosive pustular dermatosis of the scalp

Afatinib‐induced erosive pustular dermatosis of the scalp: Is there a synergistic effect between EGFR inhibitors and radiotherapy?

“…To the best of our knowledge, there are only two other EPDS cases reported associated to anti‐EGFR treatment in the scientific literature and both of them did also received radiotherapy 2 . EPDS lesions from radiotherapy alone have been described to be developed months to years after radiation treatments, with doses ranging from 2.8 to 5 Gy 5,7 . Our patient received a total of 3 Gy divided in 10 sessions, 20 months before.…”

“…lesions from radiotherapy alone have been described to be developed months to years after radiation treatments, with doses ranging from 2.8 to 5 Gy. 5,7 Our patient received a total of 3 Gy divided in 10 sessions, 20 months before. There is a wide interval between the onset of radiotherapy/EGFR inhibitors and the development of EPDS, with a median of 20 and 24 months (range 1-36 and 2-36 months, respectively) ( Table 1).…”

Erosive pustular dermatosis of the scalp: a pathogenetic мystery and therapeutic challenge

“…The provoking or triggering factors for erosive pustular dermatosis are different, often confusing for the clinician and include in turn: certain drug triggers, namely -after or within panitumumab therapy (6), after local oxygen therapy (7), after photodynamic aminolevulinic acid therapy (8), treatment with gefitinib (9), nivolumab (10), sirolimus (11), topical imiquimod (12), ingenol mebutate (13), and latanoprost (14). The triggering factors could also be of a mechanical or infectious nature such as trichotillomania e.g.…”

A case of erosive pustular dermatosis of the scalp following bullous pemphigoid in a hematopoietic stem cell transplant recipient

“…Trauma and inflammation may spread autoantigens, and activation of cellular immunity may be another factor. 3 In fact, nail deformities, one of the symptoms of chronic GVHD, occurred simultaneously with EPDS. Leukemia cutis could have contributed to the activation of cellular immunity.…”