Niveles de vitamina D en pacientes recién diagnosticados de cáncer

Calmarza, Pilar; París, Alejandro Sanz; López, Carlos González; Barrio, Mónica Llorente; Carceller, Diana Boj

doi:10.20960/nh.1675

Cited by 4 publications

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“…E por fim, notou-se que dos dez artigos, nove encontraram alguma relação entre VD e CM [19][20][21][22][23][24][25][26][27] , e outros autores demonstraram a necessidade de mais estudos para comprovar essa relação 19,20,21,22,25,26 , e apenas um autor informou que apesar de verificar uma relação, a mesma não teve efeito significativo 18 .…”

Section: Resultsunclassified

“…Calmarza et al 20 , observou que a baixa concentração de VD predispõe ao surgimento de CM e ao pior prognóstico da doença, além de verificar uma possível deficiência de VD em pacientes com CA, sugerindo uma suplementação com concentrações acima de 30 ng/ml. 18,19,20,21,23,26,27 .…”

Section: Discussionunclassified

“…Brazilian Journal of Health Review, Curitiba, v. 6, n. 2, p.7058-7070, mar./apr., 2023 concentração de vitamina D; existência de alguma relação entre VD e CM; quais artigos necessitavam de mais estudos; e a relação da VD com o CM sem efeito significativo.Cinco artigos utilizaram mulheres com CM19,20,22,25,27 , no estudo de Villaseñor et al 18 , o mesmo buscou apenas mulheres sobreviventes de CM, enquanto O'Brien et al21 , analisou mulheres com irmãs diagnosticadas com CM, mas que nunca tiveram a doença. Já Milani24 , verificou mulheres na pós-menopausa com CM, e Oliveira-Sediyama et al26 , utilizou 181 mulheres saudáveis e 197 com CM como base de seu estudo.…”

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A vitamina D interfere no tratamento nutricional de mulheres adultas com Câncer de Mama?

Ferrão¹,

Coelho²,

Pietro³

2023

Braz. J. Hea. Rev.

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Introdução: O câncer é uma doença crônica multicausal, caracterizada por células anormais que se dividem incontrolavelmente e causam disfunções no tecido corporal. Com o diagnóstico comprovado, ao iniciar o tratamento, o mesmo gera um grande impacto aos pacientes, interferindo em questões nutricionais. Dessa forma, pesquisas buscam compreender possíveis relações benéficas entre nutrientes e o câncer, tal qual a Vitamina D e o Câncer de Mama, por esta vitamina ser um regulador transcricional de vários genes envolvidos no ciclo celular, apoptose e angiogênese. Objetivos: revisar de forma sistemática artigos científicos no período de 2010 a 2021, verificando se existe relação benéfica no uso de Vitamina D em mulheres adultas com Câncer de Mama e, qual dosagem seria a ideal. Métodos: os artigos encontrados foram tabelados, ambos embasados no gênero feminino, com idade superior a 18 anos, e com análises variando de 1 mês à 9 anos. Resultados: os levantamentos mostraram que concentrações de Vitamina D nas dosagens de 30 a 90 ng/ml foram consideradas suficientes, podendo fornecer benefícios para pessoas com Câncer de Mama, fundamentando assim, as condutas nutricionais em relação a esse nutriente. Conclusão: apesar de vários estudos mostrarem efeitos positivos da Vitamina D, melhorando o prognóstico da patologia, trazendo menor mortalidade e proteção ao organismo contra o Câncer, os resultados ainda assim, são considerados inconclusivos, devido a alguns estudos serem controversos e informarem a necessidade de mais pesquisas, perante a dificuldade em medir os níveis plasmáticos dessa vitamina e por não existir um consenso entre os valores ideais.

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Section: Resultsunclassified

Section: Discussionunclassified

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A vitamina D interfere no tratamento nutricional de mulheres adultas com Câncer de Mama?

Ferrão¹,

Coelho²,

Pietro³

2023

Braz. J. Hea. Rev.

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“…Some experts now believe that low serum 25(OH)D is most likely an effect of chronic inflammation rather than the cause [ 36 , 38 ]; however, further studies are needed to answer this question [ 37 ]. Additionally, vitamin D deficiency is highly prevalent in patients with newly diagnosed cancer [ 39 , 40 , 41 ]. In order to maximize the beneficial effects of vitamin D for health, it is suggested to increase the intake of vitamin D and/or exposure of sunlight to maintain serum 25(OH)D at least at 30 ng/mL (75 nmol/L) and preferably at 40–60 ng/mL (100–150 nmol/L) [ 35 , 42 , 43 , 44 ].…”

Section: Vitamin D Sources Metabolism and Signalingmentioning

confidence: 99%

Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer

Wei

Wang

Zuo

et al. 2021

Cancers

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Pancreatic cancer has a dismal prognosis, while its incidence is increasing. This is attributed, in part, to a profound desmoplastic and immunosuppressive tumor microenvironment associated with this cancer and resistance to current available therapies. Novel and effective intervention strategies are urgently needed to improve the outcomes of patients with pancreatic cancer. Vitamin D has pleiotropic functions beyond calcium–phosphate homeostasis and has been extensively studied both in the laboratory and clinic as a potential preventive agent or adjunct to standard therapies. Accumulating evidence from ecological, observational, and randomized controlled trials suggests that vitamin D has beneficial effects on risk, survival, and mortality in pancreatic cancer, although controversies still exist. Recent advances in demonstrating the important functions of vitamin D/vitamin D receptor (VDR) signaling in the regulation of stromal reprogramming, the microbiome, and immune response and the emergence of checkpoint immunotherapy provide opportunities for using vitamin D or its analogues as an adjunct for pancreatic cancer intervention. Many challenges lie ahead before the benefits of vitamin D can be fully realized in pancreatic cancer. These challenges include the need for randomized controlled trials of vitamin D to assess its impact on the risk and survival of pancreatic cancer, optimizing the timing and dosage of vitamin D or its analogues as an adjunct for pancreatic cancer intervention and elucidating the specific role of vitamin D/VDR signaling in the different stages of pancreatic cancer. Nevertheless, vitamin D holds great promise for reducing risk and improving outcomes of this disease.

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Genetic polymorphisms related to the vitamin D pathway in patients with cirrhosis with or without hepatocellular carcinoma (HCC)

Brait¹,

Lima²,

Aguiar³

et al. 2022

ecancer

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Objective To evaluate the association of genetic polymorphisms of vitamin D transporter protein ( DBPrs4588 and DBP-rs7041 ) and cytochrome P450-24A1 ( CYP24A1-rs6013897 ) in patients with cirrhosis with or without hepatocellular carcinoma (HCC), including demographic/clinical/biochemical profiles. Methods A total of 383 individuals were studied, considering the total group (TotalG) of patients with cirrhosis (TotalG: N = 158) with or without HCC, distributed into Group 1 (G1): cirrhosis and HCC; Group 2 (G2): isolated cirrhosis; and 225 individuals without hepatopathies (G3). Polymorphisms were analysed by real-time polymerase chain reaction. An alpha error of 5% was admitted. Results CYP24A1-rs6013897 predominated the genotype with at least one polymorphic allele (_/T) in G1 (98.3%) versus G2 (88.8%; p = 0.0309). There was a moderate positive correlation between vitamin D and parathyroid hormone in patients (TotalG: R 2 = 0.3273). Smoking, alcoholism and diabetes mellitus (DM) stood out as independent factors for cirrhosis, as well as for cirrhosis with HCC, except for smoking, adding, in this case, advanced age, male gender, polymorphic allele of CYP24A1-rs6013897 , viral hepatitis and high levels of serum gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP) and creatinine. An increase in survival was observed in the presence of the polymorphic allele of DBP-rs7041 ( p = 0.0282). Conclusion CYP24A1-rs6013897 is associated with cirrhosis and HCC as a predictor, while DBP-rs4588 is associated with reduced vitamin D, and DBP-rs7041 provides increased survival, suggesting a protective characteristic. Advanced age, alcoholism, DM, viral hepatitis and high levels of GGT, AFP and creatinine are also confirmed as predictors of HCC and cirrhosis, while smoking, alcoholism and DM for isolated cirrhosis only.

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Niveles de vitamina D en pacientes recién diagnosticados de cáncer

Abstract: there is a high prevalence of vitamin D deficiency among recent diagnosed cancer patients (especially in CRC and head and neck cancer). The use of reference values adjusted by year season could improve the study of 25(OH) D concentrations.

Cited by 4 publications

References 0 publications

A vitamina D interfere no tratamento nutricional de mulheres adultas com Câncer de Mama?

A vitamina D interfere no tratamento nutricional de mulheres adultas com Câncer de Mama?

Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer

Genetic polymorphisms related to the vitamin D pathway in patients with cirrhosis with or without hepatocellular carcinoma (HCC)

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