Níveis séricos de uréia e creatinina em cães naturalmente infectados por Leishmania chagasi

Sousa, Marcus Vinicius Caetano de; Castro, Igor Paula de; Magalhães, Geórgia Modé; Mundim, Antônio Vicente; Soares, Nicolle Pereira; Noleto, Pablo Gomes; Borges, A. C.; Limongi, Jean Ezequiel; Medeiros, Alessandra Aparecida

doi:10.22256/pubvet.v5n12.1078

Cited by 2 publications

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“…The chronic character of the renal changes in CVL is evidenced by the increased serum, urea, and creatinine. However, the increase of these biochemical parameters occurs only after deposition of immunocomplexes in the kidneys (SOUSA et al, 2011) and considerable loss of approximately 75% of the nephrons of both kidneys (LANIS et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the serum biochemistry and histopathology of kidney and bladder of dogs with Leishmania sp. in their urine

et al. 2020

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The visceral establishment of Leishmania infantum in dogs may result in kidney and bladder tissue injury, with L. infantum ending up in urine. This study therefore aimed at investigating the presence of Leishmania sp. in urinary sediments, and correlating the results with those from renal and bladder serum biochemistry and histopathology. Thirty dogs with negative Nested-Polymerase Chain Reaction (PCR) for E. canis were used in the experiment, and were divided into three groups: control group (10 dogs), neither leishmaniasis nor clinical changes; group I (15 dogs), leishmaniasis but no Leishmania sp. in urine; and group II (5 dogs), leishmaniasis, as well as Leishmania sp. in urine. All animals were submitted to clinical, serological, and parasitological diagnosis for leishmaniasis, biochemical exams, and kidney and bladder histopathology. The parasite was also detected in the bladder imprint of one group II dog. Group II dogs presented with very low albumin concentrations, low albumin/globulin ratios, and kidney and bladder lesions. In the kidneys, hydropic degeneration, thickened Bowman's capsule, and thickening of the tubular capsule were detected in all dogs with positive urinary sediment. However, no significant difference in these renal changes was observed between groups. The intensity and distribution of bladder inflammatory infiltrates were significantly (p-value < 0.05, Kruskal-Wallis’ and Dunn’s tests) higher in group II dogs, compared with those of the other groups. The presence of Leishmania sp. in the urine of infected dogs appeared to be related to low serum albumin concentrations and more severe bladder lesions.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the serum biochemistry and histopathology of kidney and bladder of dogs with Leishmania sp. in their urine

et al. 2020

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“…However, it is well known that it only accumulates in blood with a severe compromise of renal function, which minimizes its role as a surrogate for renal function in the early stages of the disease. Although several studies documented azotemia in dogs with visceral leishmaniasis (Nieto et al 1992, Ciaramella et al 1997, Moura et al 2002, Sousa et al 2011, the majority of the dogs (13/18) reported here had serum creatinine within the normal limits, despite the means listed in Table 1 point towards the deterioration of renal function as the clinical scenario worsens. Nonetheless, a study by Nieto et al (1992) found elevated serum creatinine in 30% of the infected animals, which is similar to the 27.8% of azotemic dogs in this investigation.…”

Section: Discussionmentioning

confidence: 51%

“…Therefore, if the cut-off for systemic hypertension in this study was increased to 160mmHg, no dog would be considered hypertensive, even though renal lesions documented on histopathology would still be a concern. Because creatinine is completely excreted by the glomeruli, it is used as an indicator of glomerular filtration (Sousa et al 2011). However, it is well known that it only accumulates in blood with a severe compromise of renal function, which minimizes its role as a surrogate for renal function in the early stages of the disease.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure and renal injury in dogs with visceral leishmaniasis

et al. 2016

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RESUMO.-[Pressão sanguínea e lesão renal em cães com leishmaniose visceral.] A hipertensão sistêmica é reconhecida como uma consequência comum da doença renal crônica, cujo diagnóstico é frequente em cães com leishmaniose visceral. Embora muitas pesquisas veterinárias tenham investigado a lesão renal causada pela Leishmania spp., o papel dessa complicação no desenvolvimento da hipertensão arterial documentada em alguns animais com leishmaniose visceral ainda não é completamente compreendido. Systemic hypertension is known to be a common consequence of chronic renal disease, which is frequently diagnosed in dogs with visceral leishmaniasis. Although many veterinary investigations have looked at the renal injury caused by Leishmania spp., the role played by this complication in the development of arterial hypertension documented in some animals with visceral leishmaniasis is not completely understood. In this study, 18 adult dogs with naturally-occurring visceral leishmaniasis and varying clinical signs underwent an indirect blood pressure measurement. Also, sera and spot urine were used for laboratory tests. The median systolic blood pressure was 135.2mmHg (95% confidence interval: 128.5-147.7), median mean arterial pressure was 105.8mmHg (98.3-110.4), and median diastolic arterial pressure was 88.5mmHg (77.8-92.5). No differences existed between asymptomatic and symptomatic animals regarding arterial pressure, and no correlations were documented between blood pressure and serum creatinine, blood urea, urine protein-to-creatinine ratio, urine specific gravity, and the fractional excretion of sodium and potassium. Although an association between hypertension and the identification of inflammation on histopathology could not be demonstrated in hypertensive animals, the assessment of kidney samples from 12 dogs indicated mild inflammation with a lymphoplasmacytic infiltrate (6/12), moderate inflammation with multifocal lymphoplasmacytic and histiocytic infiltrates (3/12), and multifocal degeneration and protein casts (2/12). Anti-Leishmania spp. immunohistochemistry assays stained the renal epithelium in 2/12 of the animals. Even though mild systemic hypertension was documented in a small subset of animals, no relationship between the severity of clinical signs and hypertension could be anticipated. disso, foram coletados soro e urina para análises laboratoriais. As medianas das pressões arteriais sistólica, média e diastólica foram 135,2mmHg (intervalo de confiança de 95%: 128,5-147,7), 105,8mmHg (98,4) e 88,5mmHg (77,5), respectivamente. Não foram constatadas diferenças entre os cães assintomáticos e sintomáticos em relação à pressão arterial, assim como não houve correlação entre a pressão arterial e a creatinina e uréia séricas, relação proteína-creatinina urinária, densidade urinária e excreção fracionada de sódio e potássio. Embora não tenha sido evidenciada associação entre hipertensão arterial e inflamação do tecido renal à histopatologia, a avaliação das amostras oriundas de 12 cães indicou inflamação leve...

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Níveis séricos de uréia e creatinina em cães naturalmente infectados por Leishmania chagasi

Cited by 2 publications

References 0 publications

Evaluation of the serum biochemistry and histopathology of kidney and bladder of dogs with Leishmania sp. in their urine

Evaluation of the serum biochemistry and histopathology of kidney and bladder of dogs with Leishmania sp. in their urine

Blood pressure and renal injury in dogs with visceral leishmaniasis

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