Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure

Ge, Ying; Moss, Richard L.

doi:10.1161/circresaha.112.278416

Cited by 15 publications

(6 citation statements)

References 22 publications

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“…Indeed, HNO-mediated treatment for heart failure has received significant and recent attention [for example, 53,54,55]. In the scenario of heart failure, HNO is capable of enhancing Ca 2+ cycling (i.e.…”

Section: Hno Signaling/biological Activitymentioning

confidence: 99%

The chemical biology of HNO signaling

Bianco

Toscano

Bartberger

et al. 2017

Archives of Biochemistry and Biophysics

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Nitroxyl (HNO) is a simple molecule with significant potential as a pharmacological agent. For example, its use in the possible treatment of heart failure has received recent attention due to its unique therapeutic properties. Recent progress has been made on the elucidation of the mechanisms associated with its biological signaling. Importantly, the biochemical mechanisms described for HNO bioactivity are consistent with its unique and novel chemical properties/reactivity. To date, much of the biology of HNO can be associated with interactions and modification of important regulatory thiol proteins. Herein will be provided a description of HNO chemistry and how this chemistry translates to some of its reported biological effects.

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Section: Hno Signaling/biological Activitymentioning

confidence: 99%

The chemical biology of HNO signaling

Bianco

Toscano

Bartberger

et al. 2017

Archives of Biochemistry and Biophysics

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“…hearts, and holds hemodynamic advantages over existing pharmacotherapy in acute heart failure (27). Mechanistically, HNO elicits both inotropy and lusitropy via interacting with specific thiol proteins involved in Ca 2+ release and uptake within the sarcoplasmic reticulum (SR) (50,52). In failing hearts, HNO can activate cardiac thiol-containing proteins such as the sarcoplasmic ryanodine receptors (RyRs) and sarcoplasmic reticulum Ca 2+ -ATPase (SERCA2a) to increase myocardial contractility (26,155); this unique property only belongs to HNO, rather than its redox congener NO.…”

Section: Fig 6 Antioxidant Effects Of Gshmentioning

confidence: 99%

Nitroxyl as a Potential Theranostic in the Cancer Arena

Sun

Lee

Leng

et al. 2020

Antioxidants & Redox Signaling

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Significance: As one-electron reduced molecule of nitric oxide (NO), nitroxyl (HNO) has gained enormous attention because of its novel physiological or pharmacological properties, ranging from cardiovascular protective actions to antitumoricidal effects. Recent Advances: HNO is emerging as a new entity with therapeutic advantages over its redox sibling, NO. The interests in the chemical, pharmacological, and biological characteristics of HNO have broadened our current understanding of its role in physiology and pathophysiology. Critical Issues: In particular, the experimental evidence suggests the therapeutic potential of HNO in tumor pharmacology, such as neuroblastoma, gastrointestinal tumor, ovarian, lung, and breast cancers. Indeed, HNO donors have been demonstrated to attenuate tumor proliferation and angiogenesis. Future Directions: In this review, the generation and detection of HNO are outlined, and the roles of HNO in cancer progression are further discussed. We anticipate that the completion of this review might give novel insights into the roles of HNO in cancer pharmacology and open up a novel field of cancer therapy based on HNO. Antioxid. Redox Signal. 32, 331-349.

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“…HNO produces chemical and physiological functions different from NO [ 48 ] and H 2 S [ 9 , 49 ]. HNO is highly redox-sensitive and therefore regulates protein functions through “redox switches” [ 50 , 51 ]. HNO can react with thiol groups in the cysteine residues to form N-hydroxysulfenamide (RSNHOH) [ 52 ] or helps to form a reversible disulfide bond if there are two thiols residing in the near vicinity [ 53 ].…”

Section: Biochemistry Of No-h 2 S Interactimentioning

confidence: 99%

Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System

Nagpure

Bian

2015

Oxidative Medicine and Cellular Longevity

127

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Historically acknowledged as toxic gases, hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as the predominant members of a new family of signaling molecules, “gasotransmitters” in mammals. While H2S is biosynthesized by three constitutively expressed enzymes (CBS, CSE, and 3-MST) from L-cysteine and homocysteine, NO is generated endogenously from L-arginine by the action of various isoforms of NOS. Both gases have been transpired as the key and independent regulators of many physiological functions in mammalian cardiovascular, nervous, gastrointestinal, respiratory, and immune systems. The analogy between these two gasotransmitters is evident not only from their paracrine mode of signaling, but also from the identical and/or shared signaling transduction pathways. With the plethora of research in the pathophysiological role of gasotransmitters in various systems, the existence of interplay between these gases is being widely accepted. Chemical interaction between NO and H2S may generate nitroxyl (HNO), which plays a specific effective role within the cardiovascular system. In this review article, we have attempted to provide current understanding of the individual and interactive roles of H2S and NO signaling in mammalian cardiovascular system, focusing particularly on heart contractility, cardioprotection, vascular tone, angiogenesis, and oxidative stress.

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Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure

Cited by 15 publications

References 22 publications

The chemical biology of HNO signaling

The chemical biology of HNO signaling

Nitroxyl as a Potential Theranostic in the Cancer Arena

Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System

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