Nitrous oxide-induced myeloneuropathy: an emerging public health issue

McCormick, John P.; Sharpe, Sophie; Crowley, Karen; Dudley, Alexander; O’Laoi, Ruadhan; Barry, Michael; Owens, Lisa; Doherty, Colin P.; Redmond, Janice; Yeung, Sarah-Jane

doi:10.1007/s11845-022-02945-8

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…Además, es un cofactor de varios procesos dentro de los cuales se encuentra la conversión de homocisteína a metionina, de 5-metiltetrahídrofolato a tetrahidrofolato y de metil-malonil CoA a succinil CoA. El óxido nitroso inactiva la metilcobalamina oxidando el ion cobalto de la VitB12, acumulando homocisteína y alterando la síntesis de lípidos de la mielina 10,11 La presentación clínica habitual son las parestesias y adormecimiento de extremidades, seguidos de síntomas de inestabilidad para la marcha y alteraciones de la motricidad fina 7 .…”

Section: Filiación De Los Autoresunclassified

Aplasia medular tóxica

Santillán Zorrilla,

Galicia

2024

Rev Esp Urg Emerg

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nitroso es un gas incoloro, inoloro y no inflamable, de múltiples utilidades en nuestro entorno. Es un fármaco anestésico inhalatorio, usado desde hace años en intervenciones dentales o procedimientos quirúrgicos menores en pac i e n t e s p e d i á t r i c o s 1 ; también es un aditivo alimentario (E 942) utilizado en múltiples sistemas de propulsión y como estabilizador de productos envasados, y, además, se usa en el mercado de la automoción como potenciador del consumo de gasolina en el cilindro 2 .La primera referencia de su utilización como sustancia lúdica se remota a 1800, en una publicación científica en la que se describía su efecto como "hilarante y placentero" 3 .Actualmente forma parte del amplio menú de drogas de abuso. En una encuesta realizada a más de 900.000 usuarios de drogas, el 22,5% referían haberla consumido alguna vez en su vida, y el 9,7% lo había hecho durante el año anterior 4 , mientras que el EMC-DDA (Observatorio Europeo de las Drogas y las Toxicomanías), en un informe especial dedicado a esta sustancia, informaba sobre el incremento global de los casos notificados a los centros antitóxicos en distintos países; en Dinamarca se pasó de 16 casos en 2015 a 73 en 2021, en Francia, de

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Section: Filiación De Los Autoresunclassified

Aplasia medular tóxica

Santillán Zorrilla,

Galicia

2024

Rev Esp Urg Emerg

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“…It has also been used to reduce anxiety in patients with dental phobia or anxiety before medical procedures [30] . It does not present respiratory affectation, making its administration possible in patients with respiratory conditions [31] .…”

Section: Nitrous Oxide 341 Advantagesmentioning

confidence: 99%

Sedation in pediatric dentistry: A scoping review

Salinas,

Cepeda,

Capetillo

et al. 2024

Int. J. Appl. Dent. Sci.

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Introduction: Pediatric dentists face the daily challenge of treating patients with anxiety, phobias and fears, and it is important to know the drugs for each patient. Objective: To analyze the literature on drugs used for sedation, particularly dexmedetomidine, ketamine, midazolam and nitrous oxide. Methodology: Articles were searched in databases such as PubMed, Google Scholar, using keywords: sedation, drugs, pediatric dentist, pediatric patient. Results: Dexmedetomidine provides sedation, analgesia and sympathicolysis, is safe and acceptable in infants and children without respiratory depression, and adverse events such as hypoxemia and bradycardia may occur. Ketamine is a drug that presents multiple routes of administration and has analgesic, hypnotic, amnesic, anti-inflammatory and sympathomimetic properties, having undesirable side effects such as delirium, psychosis, perception disorders, arterial and intraocular hypertension. Midazolam is a fast-acting and short-acting drug, which can be administered by different routes. It presents adverse reactions such as disinhibition, hallucinations and marked respiratory depression. Oral absorption and action time are prolonged. Nitrous oxide has analgesic and anesthetic effect, as well as its rapid elimination from the body, does not affect respiration, so it is possible to administer it in patients with respiratory ailments, its use is limited to short or non-invasive procedures and can cause side effects such as nausea, vomiting, headache and fatigue. Conclusion: All the drugs reviewed have unacceptable systemic side effects, and if it is necessary to choose one, it would be nitrous oxide as the best drug to use for sedation in pediatric dentistry.

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“…Инактивация метилкобаламина происходит за счет окисления иона кобальта, что, в свою очередь, приводит к замедлению многих реакций, в которых В 12 является кофактором (превращение гомоцистеина в метионин, 5-MTHF в THF, метилмалонил-КоА в сукцинил-КоА). Данное дефицитное состояние приводит к периферическим невропатиям (59 %), подострой комбинированной дегенерации спинного мозга (36 %), токсической энцефалопатии (5 %), что в целом проявляется клинической картиной энцефаломиелополиневропатии [2][3][4].…”

Section: O N T a C T Sunclassified

Subacute combined degeneration of the spinal cord of toxic etiology (clinical case)

Kondratov,

Kotov

2024

Rus. ž. det. nevrol.

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For more than two hundred years after its discovery, nitric oxide (I) has been widely used in medicine as an anesthetic, in the car industry as an engine performance enhancer, in the food industry as a preservative, and, unfortunately, among young people as a mild narcotic substance. Despite the widespread opinion that there is no harm from the use of “laughing gas” for recreational purposes, in the literature and in practice, there are a lot of cases when patients suffer from various complications, including neurological ones, caused precisely by the use of nitric oxide (I). One of the main mechanisms of the pathological effects of nitrous oxide on the nervous tissue is the inactivation of vitamin B12. This has been proven by studying the physicochemical properties of the gas, the effect on the organisms of laboratory animals, the change in the concentration of certain substances in the human body, and also by the use of cyanocobalamin for the treatment of these patients. This article describes a clinical case of the development of myelopolyneuropathy caused by the toxic effects of nitric oxide (I).

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Nitrous oxide-induced myeloneuropathy: an emerging public health issue

Cited by 10 publications

References 15 publications

Aplasia medular tóxica

Aplasia medular tóxica

Sedation in pediatric dentistry: A scoping review

Subacute combined degeneration of the spinal cord of toxic etiology (clinical case)

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