Nitrous Oxide Exposure Among Dental Personnel and Comparison of Active and Passive Sampling Techniques

Hansen, John C.; Schaal, Nicholas; Juarez, Theodore J.; Woodlee, Charles

doi:10.1093/annweh/wxz003

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Passive samplers, which rely on less invasive technologies such as adsorbent strips and wearables like silicone wristbands, pouches, and badges, provide an alternative strategy to screen for both known and unknown exposures in large populations. PSDs validated for exposures with known uptake rates, such as benzene or trichloroethylene, have been widely used in occupational monitoring studies for industrial chemicals [23,[48][49][50][51][52][53][54]. However, for most PSDs, ongoing research is focused on better understanding the mechanisms for chemical equilibrium with sampler matrices, which can vary by chemical molecular weight, media pore size, and silicone/air partitioning coefficients [55].…”

Section: Measuring the External Exposomementioning

confidence: 99%

Operationalizing the Exposome Using Passive Silicone Samplers

et al. 2022

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The exposome, which is defined as the cumulative effect of environmental exposures and corresponding biological responses, aims to provide a comprehensive measure for evaluating non-genetic causes of disease. Operationalization of the exposome for environmental health and precision medicine has been limited by the lack of a universal approach for characterizing complex exposures, particularly as they vary temporally and geographically. To overcome these challenges, passive sampling devices (PSDs) provide a key measurement strategy for deep exposome phenotyping, which aims to provide comprehensive chemical assessment using untargeted high-resolution mass spectrometry for exposome-wide association studies. To highlight the advantages of silicone PSDs, we review their use in population studies and evaluate the broad range of applications and chemical classes characterized using these samplers. We assess key aspects of incorporating PSDs within observational studies, including the need to preclean samplers prior to use to remove impurities that interfere with compound detection, analytical considerations, and cost. We close with strategies on how to incorporate measures of the external exposome using PSDs, and their advantages for reducing variability in exposure measures and providing a more thorough accounting of the exposome. Continued development and application of silicone PSDs will facilitate greater understanding of how environmental exposures drive disease risk, while providing a feasible strategy for incorporating untargeted, high-resolution characterization of the external exposome in human studies.

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Section: Measuring the External Exposomementioning

confidence: 99%

Operationalizing the Exposome Using Passive Silicone Samplers

et al. 2022

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“…The results of this review outlined that this technique was only used in a few studies [5,51,61,62]. The IR presents some limitations, such as the need to guarantee an adequate instrumental warm-up time before starting the measurement, sensitivity to pressure differences, which must accounted for, and interference with CO 2 and water vapor [63].…”

Section: Real-time Monitoringmentioning

confidence: 99%

“…Passive or diffusive sampling requires a longer sampling time than the active sampling to collect the same amount of analyte, but is characterized by ease of use and cheapness [63,71]. Specifically, the SKC VOC-Check, 3M 3500, Draeger Orsa 5, Zambelli TK200 and ISC Maugeri Radiello ® were used in the reviewed literature.…”

Section: Time-integrated Samplingmentioning

confidence: 99%

Occupational Exposure to Halogenated Anaesthetic Gases in Hospitals: A Systematic Review of Methods and Techniques to Assess Air Concentration Levels

Keller

Cattaneo

Spinazzè

et al. 2022

IJERPH

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Objective During the induction of gaseous anaesthesia, waste anaesthetic gases (WAGs) can be released into workplace air. Occupational exposure to high levels of halogenated WAGs may lead to adverse health effects; hence, it is important to measure WAGs concentration levels to perform risk assessment and for health protection purposes. Methods A systematic review of the scientific literature was conducted on two different scientific databases (Scopus and PubMed). A total of 101 studies, focused on sevoflurane, desflurane and isoflurane exposures in hospitals, were included in this review. Key information was extracted to provide (1) a description of the study designs (e.g., monitoring methods, investigated occupational settings, anaesthetic gases in use); (2) an evaluation of time trends in the measured concentrations of considered WAGs; (3) a critical evaluation of the sampling strategies, monitoring methods and instruments used. Results Environmental monitoring was prevalent (68%) and mainly used for occupational exposure assessment during adult anaesthesia (84% of cases). Real-time techniques such as photoacoustic spectroscopy and infrared spectrophotometry were used in 58% of the studies, while off-line approaches such as active or passive sampling followed by GC-MS analysis were used less frequently (39%). Conclusions The combination of different instrumental techniques allowing the collection of data with different time resolutions was quite scarce (3%) despite the fact that this would give the opportunity to obtain reliable data for testing the compliance with 8 h occupational exposure limit values and at the same time to evaluate short-term exposures.

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