Nitrous Oxide Effects on Cerebral Evoked Potential to Pain

Chapman, C. Richard; Benedetti, C.

doi:10.1097/00132586-198006000-00008

Cited by 7 publications

(7 citation statements)

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“…It is difficult to settle the issue of whether this wave is an LPC from EPs using data recorded only at vertex, and the matter will probably remain unsolved until scalp distribution data are available. It seems unlikely, however, that this wave is an early-occurring LPC since the EP waveform observed in this study does not differ from that demonstrated in other experiments where no decision task was employed, and the most prominent positive defiection did not occur later than in our other studies (Chapman & Benedetti, 1979;Chen et al, 1979;Harkins & Chapman, 1978).…”

Section: Discussioncontrasting

confidence: 62%

Sensory Decision Theory Describes Evoked Potentials in Pain Discrimination

Chapman¹,

Chen²,

Colpitts³

et al. 1981

Psychophysiology

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The relatimship between two procedures for assessing laboratory pain. Sensory Decision Theory (SDT) psychophysics and quantificaticHi of evoked potentials, was explwed to determine whether the two methods measure a common perceptual process. Evoked potentials (EPs) were recorded from vertex while subjects poformed a conventicmal SDT discrimination task that required repetitive judgment of two painful electrical tootti stimuli delivered in random wder over trials. Peak-to-peak amplitudes and peak latencies were obtained for summation-averaged waveforms between 50 and SOO msec routed to four categories corresponding to SDT respcHise classifications: hits, false aflfirmatives, misses and correct rejections. EPs associated with hits and £alse affirmatives had significantly greater amplitudes at N157-P237 than those associated with misses and correct rejecti(»is. Peak latencies were not related to response categories. These results suggest that N1S7-P237 amplitudes associated with dental pain are appropriately described by the SDT psychophysical model, and tlu;y demcmstrate that the two paradigms assess a sin^e perceptual process associated with pain. DESCRIPTORS: Draital evoked potentials. Pain, Sensory Decision Theory. , Bmnko, & Debecker, 1977). Hillyard et al. (1971) We thank Dr. Wayne Hall for assistance m data analysis. , j , T.,^ ^^ J J • • i J 4. *;«« tn TWs research was supported by Grant #DE04004-04 from ^^^^^^^ ^^^ amplitude durmg signal detection to the National Institute of Dental Research. uncertainty reduction. Later, Squires et al. {ly'J") Address requests for reprints to: C. Richard Chapman, employed a rating scale confidence judgment re-Department of Anesthesiology RN-10, University of Wash-sponse methodology in an auditory detection task ington, Seattle, Washington 98195.and found that hit and false affirmative judgments 114 0048-5772/81/020114-07$0.70/0

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Section: Discussioncontrasting

confidence: 62%

Sensory Decision Theory Describes Evoked Potentials in Pain Discrimination

Chapman¹,

Chen²,

Colpitts³

et al. 1981

Psychophysiology

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“…Some reports have suggested that nitrous oxide produces dose-related analgesia which is reduced by opioid antagonists [15][16][17][18]. It has been postulated that nitrous oxide could release endorphins or activate endorphin systems in the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and hypnotic effects of subanaesthetic concentrations of xenon in human volunteers: comparison with nitrous oxide

Yagi

Mashimo

Kawaguchi

et al. 1995

British Journal of Anaesthesia

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The purpose of this study was to examine the effects of xenon and nitrous oxide in equipotent doses of 0.3 MAC on pain threshold and auditory response time in six healthy male volunteers. Compared with 100% oxygen inhalation, xenon and nitrous oxide significantly increased the pain threshold as measured by a radiant heat algometer. There was no significant difference in analgesic effects between xenon and nitrous oxide. Xenon significantly prolonged the response time to auditory stimuli compared with 100% oxygen, but nitrous oxide did not. The inhibitory effect of xenon on the auditory response time was significantly greater than that of nitrous oxide. The same six volunteers were studied to test if naloxone antagonized analgesia induced by xenon or nitrous oxide. The analgesic effects of xenon and nitrous oxide did not differ with or without naloxone.

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“…Its mechanism of action is incompletely understood, although some of its effects appear to be mediated through the opiate receptor [7]. Entonox, commonly known as 'gas and air', comprises a 50 : 50 mixture of nitrous oxide and oxygen, which has analgesic and sedative properties.…”

Section: Introductionmentioning

confidence: 99%