Nitrous Oxide Antagonizes CNS Stimulation by Laudanosine in Mice

Avramov, Michail N.; Mori, Kenjiro

doi:10.1093/bja/65.5.704

Cited by 6 publications

(3 citation statements)

References 22 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fifty percent nitrous oxide was continuously administered in the present study. An acute attenuation of effects on the CNS by nitrous oxide has already been reported by us and others (9)(10)(11). In our study in cats (12), rats (13) and humans (14), the maximum effect of nitrous oxide occurred in the first 30 min, and subsided gradually within 2 h to reach a steady state.…”

Section: Discussionsupporting

confidence: 78%

Effects of isoflurane on in vivo release of acetylcholine in the rat cerebral cortex and striatum

Shichino

Murakawa

Adachi

et al. 1997

Acta Anaesthesiol Scand

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 78%

Effects of isoflurane on in vivo release of acetylcholine in the rat cerebral cortex and striatum

Shichino

Murakawa

Adachi

et al. 1997

Acta Anaesthesiol Scand

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the number of participants is similar to that described in a number of other studies of spectral EEG features. 10,11,[20][21][22]…”

Section: Discussionmentioning

confidence: 99%

“…Transient changes in the EEG, namely, an increase in slow-delta power (0.1–4 Hz), have previously been described following the introduction of nitrous oxide. 20–22 In 2 of these studies, 20,21 an inhaled concentration of 65% to 70% nitrous oxide was added to between 0.75 and 1 MAC of volatile agent. In a third study, EEG analysis was performed with a nitrous concentration of >50% and a sevoflurane concentration of “≤1%.” 22 While each of these studies illustrated an increase in slow-delta activity with nitrous oxide, there are important differences between these studies and our own findings.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Spectral Features of the Frontal Electroencephalogram in Patients Receiving Xenon and Sevoflurane General Anesthesia

McGuigan

Evered

Silbert

et al. 2021

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

BACKGROUND: Depth-of-anesthesia monitoring is often utilized for patients receiving xenon anesthesia. Processed electroencephalogram (EEG) depth-of-anesthesia monitoring relies to a significant extent on frequency domain analysis of the frontal EEG, and there is evidence that the spectral features observed under anesthesia vary significantly between anesthetic agents. The spectral features of the EEG during xenon anesthesia for a surgical procedure have not previously been described. METHODS: Twenty-four participants scheduled for general anesthesia for lithotripsy were randomized to receive either xenon anesthesia or sevoflurane anesthesia. Frontal EEG recordings were obtained from each participant via the Brain Anesthesia Response Monitor (BARM). Twenty-two EEG recordings were suitable for analysis: 11 in participants who received sevoflurane and 11 in participants who received xenon. Spectrograms for the duration of the anesthetic episode were produced for each participant. Group-level spectral analysis was calculated for two 30-second EEG epochs: one recorded at awake baseline and the other during maintenance anesthesia. A linear mixed-effects model was utilized to compare the changes in 5 frequency bands from baseline to maintenance between the 2 groups. RESULTS: The spectrograms of sevoflurane participants illustrate an increase in frontal delta (0.5–4 Hz), theta (4–8 Hz), and alpha (8–13 Hz) band power during maintenance anesthesia. In contrast, spectrograms of the xenon participants did not illustrate an increase in alpha power. The results of the linear mixed-effects model indicate that both agents were associated with a significant increase in delta power from baseline to maintenance. There was no significant difference in the magnitude of this increase observed between the agents. In contrast, sevoflurane anesthesia was associated with significantly greater absolute power in the theta, alpha, and beta (13–30 Hz) bands when compared to xenon. In terms of relative power, xenon was associated with a significant increase in delta power compared to sevoflurane, while sevoflurane was associated with greater increases in relative theta, alpha, and beta power. CONCLUSIONS: Both xenon anesthesia and sevoflurane anesthesia were associated with significant increases in delta power. Sevoflurane anesthesia was also associated with increases in theta, alpha, and beta power, while xenon anesthesia was associated with greater consolidation of power in the delta band. Xenon anesthesia and sevoflurane anesthesia are associated with distinct spectral features. These findings suggest that appropriate depth-of-anesthesia monitoring may require the development of agent-specific spectral measures of unconsciousness.

show abstract

Neuromuscular blocking agents and local analgesics

Cold

Dahl

2002

Topics in Neuroanaesthesia and Neurointensive Care

View full text Add to dashboard Cite

Nitrous Oxide Antagonizes CNS Stimulation by Laudanosine in Mice

Cited by 6 publications

References 22 publications

Effects of isoflurane on in vivo release of acetylcholine in the rat cerebral cortex and striatum

Effects of isoflurane on in vivo release of acetylcholine in the rat cerebral cortex and striatum

Comparison of the Spectral Features of the Frontal Electroencephalogram in Patients Receiving Xenon and Sevoflurane General Anesthesia

Neuromuscular blocking agents and local analgesics

Contact Info

Product

Resources

About