Nitroso-caged upconversion luminescent prodrug: Near infrared light-activatable NO nano-donor for gas therapy

Tiemuer, Aliya; Yu, Hui; Zhao, Chao; Sun, Wanlu; Zhang, Yuanyuan; Jiang, Yiming; Gu, Yueqing; Liu, Yi

doi:10.1016/j.cej.2021.132858

Cited by 28 publications

(21 citation statements)

References 63 publications

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“…In a mouse model, PEG-Bn-NO was reported to successfully aggregate at the target tumor location following NIR light irradiation, and within 1 min, substantial fluorescence activation was seen. 71 (Figure 4)…”

Section: Intelligent Response Of Nano-no Donorsmentioning

confidence: 99%

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Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Huang

Zhang

Luo

et al. 2022

ACS Biomater. Sci. Eng.

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As an important endogenous signaling molecule, nitric oxide (NO) is involved in various physiological and pathological activities in living organisms. It is proved that NO plays a critical role in tumor therapy, while the extremely short half-life and nonspecific distribution of NO greatly limit its further clinical applications. Thus, the past few decades have witnessed the progress made in conquering these shortcomings, including developing innovative NO donors, especially smart and multimodal nanoplatforms. These platforms can precisely control the spatiotemporal distribution of therapeutic agents in the organism, which make big differences in tumor treatment. Here current NO therapeutic mechanisms for cancer, NO donors from small molecules to smart-responsive nanodrug delivery platforms, and NObased combination therapy are comprehensively reviewed, emphasizing outstanding breakthroughs in these fields and hoping to bring new insights into NO-based tumor treatments.

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Section: Intelligent Response Of Nano-no Donorsmentioning

confidence: 99%

Section: Intelligent Response Of Nano-no Donorsmentioning

confidence: 99%

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Huang

Zhang

Luo

et al. 2022

ACS Biomater. Sci. Eng.

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“…To effectively treat cancer, researchers have tried a variety of treatments including gene therapy, − chemotherapy, , radiotherapy, , and gas therapy. − As an emerging treatment, gas therapy uses gas transmitters to induce tumor cell death. Studies have found that several gas molecules, such as nitric oxide (NO), carbon monoxide (CO), oxygen (O 2 ), and hydrogen sulfide (H 2 S), could regulate the process of cancer. − Among them, NO was the first found gaseous biochemical messenger, and it played a dual role in tumor progression: low concentrations of NO might promote tumor growth, while high concentrations of NO (>1 μM) could induce tumor cell apoptosis through multiple pathways . In addition, when NO was used in combination with other therapeutic methods (chemotherapy, − photothermal therapy, , radiotherapy, gene therapy, etc.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

Yang

Guo

et al. 2023

Mol. Pharmaceutics

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The combination cancer therapy of nitric oxide (NO) with gene therapy is a promising method for tumor treatment. However, efficient co-delivery of gas and therapeutic genes to tumor cells remains a challenge. Herein, we designed a nano-sized ultraviolet (UV) light-responsive cationic lipid vector DPNO(Zn). Fluorescence spectroscopy and confocal imaging experiments revealed that DPNO(Zn) lipid nanoparticles (LNPs) could rapidly release NO under low-power UV light irradiation. Moreover, the fluorescence turn-on might take place along with the release of NO, indicating the self-reporting ability. Gene delivery experiments showed that DPNO(Zn) LNPs had good gene transfection ability, making such materials a good candidate for gas/gene combination therapy. In vitro antitumor assay demonstrated that the co-delivery system was more effective in inhibiting tumor cell proliferation than individual NO or pTrail treatment. Studies on the mechanism of tumor cell apoptosis induced by NO/pTrail co-delivery showed that NO could not only effectively increase the accumulation of p53 protein in tumor cells, thereby promoting the activation of caspase-3, but also induce mitochondrial damage. On the other hand, the Trail protein expressed by pTrail gene could enhance the degree of NO-induced caspase-3 activation, indicating the synergistic effect. These results proved that DPNO(Zn) LNP may serve as a multifunctional nanocarrier for potential tumor therapy.

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“…To improve the therapeutic efficacy, gas therapy, a new and potential treatment method, has drawn considerable attention in recent years. Some gaseous molecules, such as carbon monoxide (CO), sulfur dioxide (SO 2 ), , nitric oxide (NO), , hydrogen (H 2 ), , and hydrogen sulfide (H 2 S), , have unique abilities in tumor tissue. With further research, researchers found that CO can be used as a messenger molecule to regulate some physiological processes in the nervous system, cardiovascular system, , and immune system. , For instance, CO donors can directly kill cancer cells by releasing a high concentration of CO with different exogenous stimulations and enhanced chemotherapy or radiotherapy .…”

Section: Introductionmentioning

confidence: 99%

X-ray-Triggered CO Release Based on GdW₁₀/MnBr(CO)₅ Nanomicelles for Synergistic Radiotherapy and Gas Therapy

Liu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Carbon monoxide (CO) therapy has become a hot topic in the field of gas therapy because of its application prospect in the treatment of various diseases. Due to the high affinity for human hemoglobin, the main challenge of CO-loaded nanomedicine is the lack of selectivity and toxicity in the delivery process. Although many commercial CO-releasing molecules (CORMs) have been widely developed because of their ability to deliver CO, CORMs still have some disadvantages, including difficult on-demand controlled CO release, poor solubility, and potential toxicity, which are limiting their further application. Herein, an X-ray-triggered CO-releasing nanomicelle system (GW/MnCO@PLGA) based on GdW10 nanoparticles (NPs) (GW) and MnBr(CO)5 (MnCO) encapsulating in the poly(lactic-co-glycolic acid) (PLGA) polymer was constructed for synergistic CO radiotherapy (RT). The production of strongly oxidative superoxide anion (O2 –•) active species can lead to cell apoptosis under the X-ray sensitization of GW. Moreover, strongly oxidative O2 –• radicals further oxidize and compete with the Mn center, resulting in the on-demand release of CO. The radio/gas therapy synergy to enhance the efficient tumor inhibition of the nanomicelles was investigated in vivo and in vitro. Therefore, the establishment of an X-ray-triggered controlled CO release system has great application potential for further synergistic RT CO therapy in deep tumor sites.

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Nitroso-caged upconversion luminescent prodrug: Near infrared light-activatable NO nano-donor for gas therapy

Cited by 28 publications

References 63 publications

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

X-ray-Triggered CO Release Based on GdW₁₀/MnBr(CO)₅ Nanomicelles for Synergistic Radiotherapy and Gas Therapy

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Nitroso-caged upconversion luminescent prodrug: Near infrared light-activatable NO nano-donor for gas therapy

Cited by 28 publications

References 63 publications

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy

Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

X-ray-Triggered CO Release Based on GdW10/MnBr(CO)5 Nanomicelles for Synergistic Radiotherapy and Gas Therapy

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X-ray-Triggered CO Release Based on GdW₁₀/MnBr(CO)₅ Nanomicelles for Synergistic Radiotherapy and Gas Therapy