2008
DOI: 10.1016/j.freeradbiomed.2008.08.017
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Nitrones as therapeutics

Abstract: Nitrones have the general chemical formula X-CH=NO-Y. They were first used to trap free radicals in chemical systems and then subsequently in biochemical systems. More recently several nitrones including PBN (α-phenyl-tert-butylnitrone) have been shown to have potent biological activity in many experimental animal models. Many diseases of aging including stroke, cancer development, Parkinson’s disease and Alzheimer’s disease are known to have enhanced levels of free radicals and oxidative stress. Some derivati… Show more

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Cited by 206 publications
(221 citation statements)
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References 169 publications
(175 reference statements)
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“…Floyd et al (116) published a review on the potential of nitrones as therapeutics, primarily as anticancer drugs, particularly addressing the preventive action of a phenyl-tert-butylnitrone (PBN) in rat liver cancer (116). With carbon-and oxygen-centered radicals, nitrones will form nitroxides.…”
Section: The Protective Effects Of Nitroxides In Vitro and In Vivomentioning
confidence: 99%
“…Floyd et al (116) published a review on the potential of nitrones as therapeutics, primarily as anticancer drugs, particularly addressing the preventive action of a phenyl-tert-butylnitrone (PBN) in rat liver cancer (116). With carbon-and oxygen-centered radicals, nitrones will form nitroxides.…”
Section: The Protective Effects Of Nitroxides In Vitro and In Vivomentioning
confidence: 99%
“…The filtrate was concentrated under vacuum and the residue was purified by either precipitation or crystallization from a defined solvent. 69 (s, 3H, C(CH 3 ) 2 ), 1.64 (s, 3H, C(CH 3 ) 2 ), 1.22 (t, J = 7.0 Hz, 6H, 2 × OCH 2 CH 3 ); 13 C NMR (75 MHz, DMSO-d6) δ 144.9 (C-3 and C-4), 132.1 (d, J = 6.0 Hz, HC=NO), 123.2 (C-1), 122.6 (C-6), 116.1 (C-2), 115.7 (C-5), 72 N-(3,4,5-trihydroxybenzylidene)propan-2-amine oxide (3,4,5-OH-PPN; 4g). …”
Section: General Procedures For the Synthesis Of Ppns (4a−4r)mentioning
confidence: 99%
“…The title compound was obtained from 3 (500 mg, 2. 1H, HC=NO), 4.21 (m, 4H, 2 × OCH 2 CH 3 ), 1.89 (s, 3H, C(CH 3 ) 2 ), 1.84 (s, 3H, C(CH 3 ) 2 ), 1.34 (t, J = 7.0 Hz, 6H, 2 × OCH 2 CH 3 ); 13 C NMR (75 MHz, CDCl 3 ) δ 147.8 (C-4), 136.2 (d, J = 1.5 Hz, C-1 -PPN; 4m) …”
Section: -(Diethoxyphosphoryl)-n-(4-hydroxy-35-dimethoxybenzylidenementioning
confidence: 99%
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