Nitroimidazoles. Part 3. Synthesis and anti‐HIV Activity of New N‐Alkyl‐4‐nitroimidazoles Bearing Benzothiazole and Benzoxazole Backbones.

Al‐Soud, Yaseen A.; Al-Sa’doni, Haitham H.; Amajaour, Houssain A. S.; Al‐Masoudi, Najim A.

doi:10.1002/chin.200731190

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2007

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“…On the basis of this strategy, in this present study 4-nitroimidazoles bearing alkylpiperazine residues at C-5 have been selected as new lead templates that might lead to the opimization of HIV-1 RT inhibitory activity. (Nitroimidazoles Parts 1-5 have been published elsewhere: Al-Soud & Al-Masoudi, 2005;Al-Masoudi et al 2006a, 2007bAl-Soud et al 2006b, 2007b.…”

confidence: 99%

Nitroimidazoles Part 6. Synthesis, Structure andin Vitroanti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives

Al‐Masoudi

Al‐Soud

Clercq

et al. 2007

Antivir Chem Chemother

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2-Amino-1-[4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl]ethanone [6] was prepared from 1-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl) piperazine [3]. A series of new 2-oxoethyl-arylamide [9,10] and 2-oxoethyl-arylsulphonamide [11-14] derivatives were synthesized from [6] with the aim of developing new non-nucleoside reverse transcriptase inhibitors. Alternatively, the amine [17] was synthesized from [3] via the phthalimide derivative [16]. The arylsulphonamide derivatives [18-23] and the arylamide analogues [24-26] were synthesized from [17]. The compounds were evaluated for their anti-HIV-1 and anti-HIV-2 activity in MT-4 cells.

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confidence: 99%

Nitroimidazoles Part 6. Synthesis, Structure andin Vitroanti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives

Al‐Masoudi

Al‐Soud

Clercq

et al. 2007

Antivir Chem Chemother

View full text Add to dashboard Cite

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Nitroimidazoles. Part 3. Synthesis and anti‐HIV Activity of New N‐Alkyl‐4‐nitroimidazoles Bearing Benzothiazole and Benzoxazole Backbones.

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cited by 1 publication

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Nitroimidazoles Part 6. Synthesis, Structure andin Vitroanti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives

Nitroimidazoles Part 6. Synthesis, Structure andin Vitroanti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives

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