Nitroglycerine ointment as aid to venous cannulation in children

Vaksmann, Guy; C, Rey; Breviere, G. M.; Smadja, D.; Dupuis, C

doi:10.1016/s0022-3476(87)80350-5

Cited by 23 publications

(20 citation statements)

References 4 publications

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“…It is possible that topical application of nitroglycerine is effective in premature babies because of increased permeability of the immature skin especially during the first 5 days of life. 18 Vaksmann et al 14 found the greatest effect with topical nitroglycerine in young infants, although the response observed in his series might have been related to the use of a higher dose of nitroglycerine. 14 This is the first reported case of the efficacy of nitroglycerine topical application for cutaneous ischaemic changes due to umbilical arterial lines.…”

Section: Discussionmentioning

confidence: 84%

“…18 Vaksmann et al 14 found the greatest effect with topical nitroglycerine in young infants, although the response observed in his series might have been related to the use of a higher dose of nitroglycerine. 14 This is the first reported case of the efficacy of nitroglycerine topical application for cutaneous ischaemic changes due to umbilical arterial lines. It is possible that nitroglycerine application could be effective in cases where the ischaemia involves only the skin and not deep and bigger blood vessels.…”

Section: Discussionmentioning

confidence: 84%

“…2,8 Indeed, topical nitroglycerine has been shown to induce venous dilatation to facilitate venous cannulation in adults 13 and children. 14 Common adverse effects of nitroglycerine include headache and dizziness in adults although serious side effects are rare. 8 -10 Tachycardia and hypotension are other important side effects, but limited data suggest that these complications have been rare among neonatal and pediatric populations.…”

Section: Discussionmentioning

confidence: 99%

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Successful Use of Topical Nitroglycerine in Ischaemia Associated With Umbilical Arterial Line in a Neonate

Varughese

Koh

2001

J Perinatol

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Successful Use of Topical Nitroglycerine in Ischaemia Associated With Umbilical Arterial Line in a Neonate

Varughese

Koh

2001

J Perinatol

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“…10,11 In contrast, a small study in neonates found less successful intravenous cannulation and an excess of bleeding and infiltration in the NGO group compared to controls. 12 Nevertheless, we speculated that while the local vasodilatory effects may not help (and may actually hinder) venous cannulation in newborns, such effects might benefit heelstick blood collection.…”

Section: Discussionmentioning

confidence: 89%

“…When used topically, nitroglycerine ointment (NGO) produces local vasodilatation and has been used in adults and children to facilitate venipuncture or intravenous cannulation. 10,11 In small amounts, its systemic absorption is insignificant and side effects such as hypotension and methemoglobinemia can be avoided. We designed this study to determine if topical NGO would safely reduce the collection time and associated pain/distress with heelstick blood collection for routine newborn metabolic screening.…”

Section: Introductionmentioning

confidence: 99%

Can Nitroglycerine Ointment Facilitate Newborn Heelstick Blood Collection? A Randomized Controlled Trial

2003

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Newborn heelstick blood collection can be a painful procedure in part because of the time required to obtain sufficient quantity of blood. No previous studies have determined whether local vasodilatation using topical nitroglycerine ointment (NGO) would facilitate heelstick blood collection. OBJECTIVE:To determine if the topical application of NGO would reduce the time needed to collect the required amount of blood for newborn metabolic screening and, in turn, reduce the pain/distress of the procedure. STUDY DESIGN:In a randomized, prospective, placebo controlled and blinded fashion, term newborns in a well nursery received either topical nitroglycerine or placebo ointment 10 minutes prior to heelstick. Total time and number of heelsticks required to complete the collection were measured along with crying time, heart rate and blood pressure. RESULTS:In all, 50 were studied, 25 in each group. There was no statistical difference between groups in collection time, crying time or number of heelsticks required for completion. Heart rate increased significantly and equally in both groups. Blood pressures were unchanged. CONCLUSIONS:Topical NGO did not facilitate heelstick blood collection or reduce the pain/distress of the procedure.

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‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate

Loder

Kamm

Nicholls

et al. 1994

British Journal of Surgery

221

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Nitric oxide has emerged as one of the most important neurotransmitters mediating internal anal sphincter relaxation. The effect of glyceryl trinitrate, a nitric oxide donor, on anal tone was examined. Maximum resting pressure, predominantly a function of the smooth muscle internal anal sphincter, was measured before and 20 min after application of 0.2 per cent glyceryl trinitrate ointment in ten patients. Pressure decreased by a mean of 27 per cent (95 per cent confidence interval 18-36 per cent) (P = 0.0004) after administration of the drug. A further 20 patients were then randomized to either active or placebo ointment. Anal pressure was significantly decreased (P = 0.002) in those who received 0.2 per cent glyceryl trinitrate, but there was no significant reduction in the control patients. Mild headache occurred in two patients who were given the active preparation and in one who received placebo. Manometry was repeated 9h after application of glyceryl trinitrate and showed a sustained decrease in pressure in two patients. Topical glyceryl trinitrate may have a role in the treatment of anal fissure, haemorrhoids, certain types of constipation and anal pain. It may also reduce injury to the internal sphincter during peranal operations.

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Nitroglycerine ointment as aid to venous cannulation in children

Cited by 23 publications

References 4 publications

Successful Use of Topical Nitroglycerine in Ischaemia Associated With Umbilical Arterial Line in a Neonate

Successful Use of Topical Nitroglycerine in Ischaemia Associated With Umbilical Arterial Line in a Neonate

Can Nitroglycerine Ointment Facilitate Newborn Heelstick Blood Collection? A Randomized Controlled Trial

‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate

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