Nitroglycerin Pharmacokinetics After Intravenous Infusion in Normal Subjects

McNiff, Edward F.; Yacobi, Avraham; Young-Chang, F.M.; Golden, Lawrence H.; Goldfarb, Allen L.; Fung, Ho‐Leung

doi:10.1002/jps.2600700923

Cited by 107 publications

(25 citation statements)

References 16 publications

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“…This has been recorded at more than 5 /min, which is over three times liver blood flow (McNiff et al, 1981). This indicates that extra-hepatic elimination occurs, and it is now recognized that red blood cells may be the primary site of nitroglycerin metabolism.…”

mentioning

confidence: 77%

Influence of posture on plasma nitroglycerin [letter]

Curry¹,

Kwon²

1985

Brit J Clinical Pharma

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mentioning

confidence: 77%

Influence of posture on plasma nitroglycerin [letter]

Curry¹,

Kwon²

1985

Brit J Clinical Pharma

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“…There is less interindividual fluctuation of pharmacokinetic parameters for glycerol mononitrate than for nitroglycerin. Other pharmacokinetic studies with man have shown that the distribution volume for glycerol mononitrate is about half of that for nitroglycerin (65).…”

Section: Metabolismmentioning

confidence: 91%

“…The data on nitroglycerin concentrations in plasma after intravenous infusion also differ widely (9,19,51,65,84,86,95,102). The reasons for the interindividual and intraindividual variability according to Sorkin et al (95) are the rapid metabolism of nitroglycerin in blood at 37 °C, absorption by PVC, which is used in many intravenous infusion systems, and the differences in the sensitivity of the methods of detection.…”

Section: Intravenous Infusionmentioning

confidence: 99%

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Nitroglycerin [BAT Value Documentation, 1998]

Bolt¹

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Biological Exposure Values for Occupational Toxicants and Carcinogens , Vol. 3 (1998) The article contains sections titled: Pharmacokinetics and Pharmacodynamics Kinetics Metabolism Dose‐dependency of the Effects of Nitroglycerin Pharmacodynamics Interaction Critical Toxicity Exposure and Effects Relationship between External and Internal Exposure Relationship between Internal Exposure and Effect Selection of the Indicators Nitroglycerin in Blood Glycerol‐1,2‐dinitrate and Glycerol‐1,3‐dinitrate in Blood Methodology Background Exposure Evaluation of the BAT Value Interpretation of the Data

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“…These findings support the interpretation that body water is the principal correlate of the volume of G-1-N distribution. For the lipophilic parent substance glyceryl trinitrate (GTN) tissue distribution plays a more important role (Imhof et al, 1982) and the distribution volume is at least twice as high as that of G-1-N (McNiff et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Glyceryl‐1‐nitrate pharmacokinetics in healthy volunteers.

Laufen

Leitold

1987

Brit J Clinical Pharma

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1 The plasma kinetics and urinary excretion of glyceryl-1-nitrate (G-1-N), a metabolite of glyceryl trinitrate with antianginal potential, were investigated in 10 healthy male volunteers, after intravenous infusion and oral administration of 20 mg G-1-N. 2 The apparent volume of G-1-N distribution was 601 corresponding to 0.761 kg-1 body weight, on average. It is suggested that total body water is the principal biological correlate of the hydrophilic drug.3 Mean intravenous clearance was 283 ml min-' or 3.61 ml min-1 kg-1. The average of elimination half-lives were 2.50 ± 0.36 (s.d.) h after the intravenous and 2.54 ± 0.40 (s.d.) h after the oral dose. 4 Inter-subject variances of pharmacokinetic parameters were low compared to variances reported for glyceryl trinitrate. The coefficient of intra-subject variation of the elimination half-lives was 8.8%. 5 5.5% (i.v.) and 5.4% (p.o.) of the administered dose were excreted into urine up to 48 h after the administration. 1% (i.v.) and 1.5% (p.o.) were in the conjugated form. 6 The oral dose was rapidly and almost completely absorbed. The oral bioavailability on the basis of areas under the curve amounted to 88.6% on the average. 7 For clinical use, owing to its high oral bioavailability, long residence in the body, inactivation by metabolic conversion, and good predictability of kinetic parameters, G-1-N offers advantage over glyceryl trinitrate.

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Nitroglycerin Pharmacokinetics After Intravenous Infusion in Normal Subjects

Cited by 107 publications

References 16 publications

Influence of posture on plasma nitroglycerin [letter]

Influence of posture on plasma nitroglycerin [letter]

Nitroglycerin [BAT Value Documentation, 1998]

Glyceryl‐1‐nitrate pharmacokinetics in healthy volunteers.

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