Nitrogen Storage Following Intravenous and Oral Administration of Casein Hydrolysate to Infants With Acute Gastro-Intestinal Disturbance 1

Shohl, Alfred T.

doi:10.1172/jci101391

Cited by 21 publications

(3 citation statements)

References 5 publications

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“…Casein hydrolysate was generally well tolerated by mouth, in keeping with the experience of others (Lewes, 1944;Shohl, 1943;Hartmann et al, 1944), but the number of cases is too few to permit a final opinion on this point. It was certainly encouraging to find the digestion settling well at the height of treatment (Cases 1, 2, and 4).…”

Section: Resultssupporting

confidence: 74%

See 1 more Smart Citation

Liver Damage in Gastro-Enteritis

Schlesinger¹,

Payne²,

Burnard³

1949

Archives of Disease in Childhood

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Section: Resultssupporting

confidence: 74%

“…Protein, it was argued, would also supply badly needed nitrogen and calories. Later,' when the lesion was suspected to be of a more complex nature, justification for this form of therapy appeared even greater, since more than one of the amino-acid constituents of the protein molecule might be required (Witts, 1947).…”

Section: Clinical Investigationsmentioning

confidence: 99%

Liver Damage in Gastro-Enteritis

Schlesinger¹,

Payne²,

Burnard³

1949

Archives of Disease in Childhood

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“…Search for a means of providing protein parenterally when the oral route fails has produced protein digests of definite value (6,24,13). Our first trial of solutions of the ten essential amino acids plus glycine suggested that these amino acid solutions were superior to any digests we had tested (11).…”

Section: Discussionmentioning

confidence: 99%

Amino Acid Mixtures Effective Parenterally for Long Continued Plasma Protein Production. Casein Digests Compared

Madden

Woods

Shull

et al. 1944

Journal of Experimental Medicine

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Our objective in the experiments tabulated below is a better understanding of the amino acid requirements for plasma protein production. It is important to determine the optimal make-up of mixtures which are used by the plasma-depleted dog to produce new plasma proteins. Briefly it may be said that the better mixtures of amino acids rate with the best food proteins in the production of new plasma protein in dogs standardized as described below under Methods. They are better tolerated when given intravenously than are casein digests, producing no clinical disturbance when given several times faster than the tolerable rate for such digests. They provide nitrogen balance as well as plasma protein production over periods of several months.In a previous report (11) it was found that good plasma protein regeneration was obtained from feeding or injecting the ten amino acids determined by Rose (21) to be essential for the growth of rats. Further tests have now been made of various mixtures of these ten acids and of non-essential amino acids. Similar mixtures of the ten essential amino acids plus glycine have appeared similarly well used and tolerated in the first trial in a human patient recently reported (2) as well as in other trials in patients to be reported soon. These mixtures appear not to have the undesirable vomiting and pyrogenic effects noted in an earlier report regarding the use in infants of an amino acid mixture containing more of the non-essential amino acids (25).Subcutaneous administration of the better mixtures of amino acids in 10 per cent solution in distilled water produces no clinical disturbance in dogs or in man and is accompanied by good utilization. The availability of the subcutaneous route is a great boon in many instances where repeated daffy injections are indicated. It is particularly fortunate that solutions of high concentration are so well tolerated.* We are indebted to Merck and Company, Inc., for the crystalline amino acids used in these experiments.We are indebted to Eli Lilly and Company for aid in conducting this work and for valuable materials. 6O7

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Gastroenterology

Jones¹

1944

Arch Intern Med (Chic)

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Nitrogen Storage Following Intravenous and Oral Administration of Casein Hydrolysate to Infants With Acute Gastro-Intestinal Disturbance 1

Cited by 21 publications

References 5 publications

Liver Damage in Gastro-Enteritis

Liver Damage in Gastro-Enteritis

Amino Acid Mixtures Effective Parenterally for Long Continued Plasma Protein Production. Casein Digests Compared

Gastroenterology

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