Nitrogen Retention, Creatinuria, and Other Effects of the Treatment of Simmonds' Disease With Methyl Testosterone

Werner, Sidney C.; West, Randolph

doi:10.1172/jci101402

Cited by 20 publications

(6 citation statements)

References 27 publications

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“…Methyl testosterone caused no increase in the excretion of 17ketosteroids whereas testosterone propionate caused an increase; these findings are in accord with those of previous observers (12,19,44,60,66). However, it usually caused a decreased excretion of sodium, chloride, potassium, and nitrogen.…”

Section: Fig 5 Response Insupporting

confidence: 91%

“…The anabolic effects of testosterone have been utilized, with some success, in the treatment of Cushing's disease (1), Simmonds' disease (66,68), and Addison's disease (39,60). To a male and a female patient with Addison's disease, Kenyon and associates (39) administered 25 mg. of testosterone propionate daily for five days.…”

Section: Fig 5 Response Inmentioning

confidence: 99%

“…Werner and West (66) reported that "striking subjective, objective, and laboratory changes followed the treatment with methyl testosterone of four patients with Simmonds' disease. Clinically, the patients demonstrated renewed vigor, sense of strength and libido, and redeveloped secondary sex characteristics."…”

Section: Fig 5 Response Inmentioning

confidence: 99%

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Treatment of Adrenal Insufficiency

Williams

Whittenberger

Bissell

et al. 1945

The Journal of Clinical Endocrinology & Metabolism

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Section: Fig 5 Response Insupporting

confidence: 91%

Section: Fig 5 Response Inmentioning

confidence: 99%

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Treatment of Adrenal Insufficiency

Williams

Whittenberger

Bissell

et al. 1945

The Journal of Clinical Endocrinology & Metabolism

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“…Good therapeutic results with androgens have been reported by a number of investigators, chiefly Means et al (1940), Escamilla & Lisser (1942, , Werner & West (1943), Glass (1944), Lisser & Curtis (1945), Burke & Cantor (1945), and McGavack et al (1946).…”

Section: Introductionmentioning

confidence: 92%

The Effect of Desoxycorticosterone Acetate and Sodium Chloride, Thyroxin and Testosterone Propionate in a Case of Panhypoadenopituitarism (Simmonds' Disease) With Special Reference to Kidney Function and Blood Pressure

Luft¹,

Sjögren²

1949

Acta Endocrinologica

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“…Simultaneously, Samuels, Henschel, and Keys (2) discovered that the same effects occurred in normal men. Since then Tager (3), Werner and West (4), and others (5, 6, 7) have observed that creatinuria followed the use of methyl testosterone in various conditions. The present paper deals with further studies we have made to determine the nature of the changes which occur in the creatinecreatinine metabolism.…”

mentioning

confidence: 99%

Studies on the Creatinuria Due to Methylated Steroids 1

Wilkins

Fleischmann²

1945

J. Clin. Invest.

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We reported in 1941 that the oral administration of methyl testosterone caused a. marked increase of creatine excretion in sexually undeveloped dwarfs (1). Simultaneously, Samuels, Henschel, and Keys (2) discovered that the same effects occurred in normal men. Since then Tager (3), Werner and West (4), and others (5, 6, 7) have observed that creatinuria followed the use of methyl testosterone in various conditions. The present paper deals with further studies we have made to determine the nature of the changes which occur in the creatinecreatinine metabolism. METHODSThe observations we are reporting were made principally on sexually undeveloped dwarfs between the ages of 11 and 22 years because we were at the same time studying the protein anabolic effects of steroids in this group of patients. It is probable that the dwarfism and sexual infantilism were due to pituitary deficiency in most instances, although this diagnosis cannot be proved in all cases. The fact that methyl testosterone has identical effects on the creatine metabolism in normal individuals and in patients of either sex suffering from other disturbances has been amply demonstrated by Samuels, ourselves, and other workers.All patients received "low creatine" diets containing no meat or fish, and not over 1000 ml. of milk daily, furnishing 30 mgm. or less of creatine. During each study, the diet was constant in respect to the content of protein, carbohydrate, and fat. Twenty-four-hour specimens of urine were collected over dilute HCI and analyzed daily by the method of Benedict and Myers (8), using a Klett photoelectric colorimeter for the readings. In presenting the results of the first 24 days of treatment, we employed the method of "sliding averages" using 5-day periods to compute the daily outputs. By this method, the average of days 1 to 5 inclusive are shown as the output for the third day, which is the middle of the period; the average of days 2 to 6 inclusive are recorded as the 4th day; 3 to 7 as the 5th day, etc.2 The values recorded for the excretion after the first month of treatment are averages for periods of 10 days or longer. To emphasize the early changes, the time intervals of one day are shown on the abscissae of the chart for the first month; but to conserve-space, the same interval represents one month in the remainder of the chart. This causes the rise in the curve of excretion after the first month to appear more abrupt than it actually is.It is seen from this chart that after treatment with methyl testosterone is begun there is a latent period varying from approximately 4 to 16 days before the excretion of creatine increases. During this period, the output of creatine apparently decreases in some cases. The creatinine curves are more irregular than those of creatine, but in many instances, there also appears to be a decreased output during the early period of (Col. U. S. A.). The contents of this paper have been reported from time to time in the minutes of the Committee on the Metabolic Aspects of Convalescence.2 By this m...

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Nitrogen Retention, Creatinuria, and Other Effects of the Treatment of Simmonds' Disease With Methyl Testosterone

Cited by 20 publications

References 27 publications

Treatment of Adrenal Insufficiency

Treatment of Adrenal Insufficiency

The Effect of Desoxycorticosterone Acetate and Sodium Chloride, Thyroxin and Testosterone Propionate in a Case of Panhypoadenopituitarism (Simmonds' Disease) With Special Reference to Kidney Function and Blood Pressure

Studies on the Creatinuria Due to Methylated Steroids 1

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