Nitrogen Mustard Therapy with Aortic Occlusion in Nasopharyngeal Carcinoma

Malignant Tumours of Nasopharynx in Delhi

“…Nasal symptoms, consisting of epistaxis and nasal obstruction predominates, 62-5 per cent., and glandular swellings being 58-3 per cent, which is slightly less than the nasal symptoms. Thus there is a deviation from the standard clinical pattern in the series of Clifford and Beecher (1964), Lederman (1961) and Digby et al (1941), where glandular swelling predominated.…”

“…(Stacruz and Dos Santos, 1955). Clifford et al (1963) presented a large series of cases treated in Kenya, East Africa and found tumours of the nasopharynx in 29 per cent, of total patients with tumours of head and neck.…”

“…In Chinese, the mean average age is 38-4 for males and 34-5 years for females as quoted by the above author. The age group for East Africans is 29-59 (Clifford and Beecher 1964). The high age incidence amongst English patients is not significant in view of high life expectancy.…”

“…In a centre like Kenya, where there are no facilities of radiotherapy, an extensive trial of chemotherapy is being done (Clifford et al, 1963). Though the types of patients presenting are also the same in India, the use of chemotherapeutic agents has to be abandoned due to their limited supply.…”

Prospectives in head and neck oncology

“…Selective anti-cancer effects have been sought by limiting the area of the body affected by the drug such as by regional perfusion devised by Creech and Krementz (1964) to treat melanomata of the limbs or by regional infusions in head and neck cancers (Sullivan et al, 1959;Clifford, 1964) or by limiting the distribution of the drug to one half of the body (Clifford et al, 1963). A knowledge of the mode of action of cytotoxic drugs and the growth rates and kinetics of malignant and vital stem cell systems is necessary to determine optimum chemotherapy dosage schedules.…”