Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio
Marietta Straub,
Alexandra Auderset,
Laurence de Leval
et al.
Abstract:Studies have suggested that cancerous tissue has a lower 15N/14N ratio than benign tissue. However, human data have been inconclusive, possibly due to constraints on experimental design. Here, we used high-sensitivity nitrogen isotope methods to assess the 15N/14N ratio of human breast, lung, and kidney cancer tissue at unprecedented spatial resolution. In lung, breast, and urothelial carcinoma, 15N/14N was negatively correlated with tumor cell density. The magnitude of 15N depletion for a given tumor cell den… Show more
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